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A case of epidermolysis bullosa acquisita with autoantibody to anti-p200 pemphigoid antigen and exfoliative esophagitis.
Dermatology. 2006; 212(4):381-4.D

Abstract

BACKGROUND

Some cases of a subepidermal blistering disease associated with autoantibodies to more than two antigens have been reported.

OBSERVATION

A 52-year-old Japanese woman had pruritic blisters on almost the whole body as well as erosive lesions in the oral cavity and esophagus. A histological finding was subepidermal bullae. Direct immunofluorescence (IF) revealed a linear deposition of IgG, IgM and C3 at the epidermal basement membrane zone (BMZ). Indirect IF using human skin split by 1 M NaCl as a substrate showed IgG antibody reactive with the dermal side. By immunoblot analysis using normal human dermal extract, the 200-kDa and 290-kDa bands were detected. Indirect IF did not show any anti-BMZ antibody activity, when using the skin of the patient with recessive dystrophic epidermolysis bullosa as a substrate.

CONCLUSION

We regarded our case as epidermolysis bullosa acquisita with autoantibody to anti-p200 pemphigoid antigen. This is the second case in the literature associated with autoantibodies to these two antigens.

Authors+Show Affiliations

Department of Dermatology, Jichi Medical School, Tochigi, Japan. tomoko-y@jichi.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16707891

Citation

Yamada, Tomoko, et al. "A Case of Epidermolysis Bullosa Acquisita With Autoantibody to Anti-p200 Pemphigoid Antigen and Exfoliative Esophagitis." Dermatology (Basel, Switzerland), vol. 212, no. 4, 2006, pp. 381-4.
Yamada T, Suzuki M, Koike Y, et al. A case of epidermolysis bullosa acquisita with autoantibody to anti-p200 pemphigoid antigen and exfoliative esophagitis. Dermatology. 2006;212(4):381-4.
Yamada, T., Suzuki, M., Koike, Y., Kida, K., Murata, S., Ishii, N., Hashimoto, T., & Ohtsuki, M. (2006). A case of epidermolysis bullosa acquisita with autoantibody to anti-p200 pemphigoid antigen and exfoliative esophagitis. Dermatology (Basel, Switzerland), 212(4), 381-4.
Yamada T, et al. A Case of Epidermolysis Bullosa Acquisita With Autoantibody to Anti-p200 Pemphigoid Antigen and Exfoliative Esophagitis. Dermatology. 2006;212(4):381-4. PubMed PMID: 16707891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of epidermolysis bullosa acquisita with autoantibody to anti-p200 pemphigoid antigen and exfoliative esophagitis. AU - Yamada,Tomoko, AU - Suzuki,Masayuki, AU - Koike,Yumiko, AU - Kida,Kinuyo, AU - Murata,Satoru, AU - Ishii,Norito, AU - Hashimoto,Takashi, AU - Ohtsuki,Mamitaro, PY - 2005/05/19/received PY - 2005/11/05/accepted PY - 2006/5/19/pubmed PY - 2006/11/4/medline PY - 2006/5/19/entrez SP - 381 EP - 4 JF - Dermatology (Basel, Switzerland) JO - Dermatology VL - 212 IS - 4 N2 - BACKGROUND: Some cases of a subepidermal blistering disease associated with autoantibodies to more than two antigens have been reported. OBSERVATION: A 52-year-old Japanese woman had pruritic blisters on almost the whole body as well as erosive lesions in the oral cavity and esophagus. A histological finding was subepidermal bullae. Direct immunofluorescence (IF) revealed a linear deposition of IgG, IgM and C3 at the epidermal basement membrane zone (BMZ). Indirect IF using human skin split by 1 M NaCl as a substrate showed IgG antibody reactive with the dermal side. By immunoblot analysis using normal human dermal extract, the 200-kDa and 290-kDa bands were detected. Indirect IF did not show any anti-BMZ antibody activity, when using the skin of the patient with recessive dystrophic epidermolysis bullosa as a substrate. CONCLUSION: We regarded our case as epidermolysis bullosa acquisita with autoantibody to anti-p200 pemphigoid antigen. This is the second case in the literature associated with autoantibodies to these two antigens. SN - 1018-8665 UR - https://www.unboundmedicine.com/medline/citation/16707891/A_case_of_epidermolysis_bullosa_acquisita_with_autoantibody_to_anti_p200_pemphigoid_antigen_and_exfoliative_esophagitis_ L2 - https://www.karger.com?DOI=10.1159/000092292 DB - PRIME DP - Unbound Medicine ER -