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Correlation of improved erectile function and rate of successful intercourse with improved emotional well-being assessed with the Self-Esteem And Relationship questionnaire in men treated with sildenafil for erectile dysfunction and stratified by age.
Curr Med Res Opin. 2006 May; 22(5):939-48.CM

Abstract

BACKGROUND

The quality of life consequences of erectile dysfunction (ED) include depression, anxiety, and loss of self-esteem. The Self-Esteem And Relationship (SEAR) questionnaire is a validated, patient-administered, psychometric instrument specific to ED.

OBJECTIVE

To determine correlations between erectile function (EF), intercourse success, and emotional well-being measured with the SEAR questionnaire in men treated with sildenafil citrate for ED and stratified by age (< 50 years, 50-65 years, and > 65 years).

RESEARCH DESIGN AND METHODS

This was an open-label, flexible-dose trial of sildenafil (25, 50 and 100 mg) administered for 10 weeks to 382 men with ED (mean +/- SD age, 55 +/- 13 years; mean ED duration, 4 years), which was conducted at 62 centers in the United States.

MAIN OUTCOME MEASURES

Analysis (by intent-to-treat, n = 368) of the change from baseline to the week-10 endpoint in the SEAR questionnaire Self-Esteem subscale, the intercourse success rate (percent of occasions at which an erection that lasted long enough for successful intercourse was achieved), and their correlation.

RESULTS

For the overall population, there was mean +/- SD improvement (p < 0.0001, paired t-tests) in the Self-Esteem subscale (56 +/- 25 to 79 +/- 22) and intercourse success rate (21 +/- 30% to 70 +/- 36%), which showed positive correlation (p < 0.0001). Secondary outcomes (i.e., EF domain of the International Index of Erectile Function; event log frequency of erection hard enough for sexual intercourse and of ejaculation/orgasm) also improved (p < 0.0001) and correlated positively with the SEAR Self-Esteem subscale and Sexual Relationship domain (p < 0.05 for all correlations). All 10 correlations were positive (p < 0.05) in men aged 50 to 65 years, eight were positive in men aged > 65 years, and six were positive in men aged < 50 years. The most common treatment-related adverse events were mild-to-moderate headache (12% of patients), vasodilatation (7%), and rhinitis (4%).

CONCLUSIONS

Men treated with sildenafil for ED demonstrated improved erectile function and an increased intercourse success rate, which correlated positively with improvement in SEAR measures of self-esteem and sexual relationship.

Authors+Show Affiliations

Northeast Indiana Research, LLC, Fort Wayne, IN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16709315

Citation

Steidle, Christopher P., et al. "Correlation of Improved Erectile Function and Rate of Successful Intercourse With Improved Emotional Well-being Assessed With the Self-Esteem and Relationship Questionnaire in Men Treated With Sildenafil for Erectile Dysfunction and Stratified By Age." Current Medical Research and Opinion, vol. 22, no. 5, 2006, pp. 939-48.
Steidle CP, Stecher VJ, Pace C, et al. Correlation of improved erectile function and rate of successful intercourse with improved emotional well-being assessed with the Self-Esteem And Relationship questionnaire in men treated with sildenafil for erectile dysfunction and stratified by age. Curr Med Res Opin. 2006;22(5):939-48.
Steidle, C. P., Stecher, V. J., Pace, C., & Tseng, L. J. (2006). Correlation of improved erectile function and rate of successful intercourse with improved emotional well-being assessed with the Self-Esteem And Relationship questionnaire in men treated with sildenafil for erectile dysfunction and stratified by age. Current Medical Research and Opinion, 22(5), 939-48.
Steidle CP, et al. Correlation of Improved Erectile Function and Rate of Successful Intercourse With Improved Emotional Well-being Assessed With the Self-Esteem and Relationship Questionnaire in Men Treated With Sildenafil for Erectile Dysfunction and Stratified By Age. Curr Med Res Opin. 2006;22(5):939-48. PubMed PMID: 16709315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of improved erectile function and rate of successful intercourse with improved emotional well-being assessed with the Self-Esteem And Relationship questionnaire in men treated with sildenafil for erectile dysfunction and stratified by age. AU - Steidle,Christopher P, AU - Stecher,Vera J, AU - Pace,Cindy, AU - Tseng,Li-Jung, AU - ,, PY - 2006/5/20/pubmed PY - 2006/9/23/medline PY - 2006/5/20/entrez SP - 939 EP - 48 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 22 IS - 5 N2 - BACKGROUND: The quality of life consequences of erectile dysfunction (ED) include depression, anxiety, and loss of self-esteem. The Self-Esteem And Relationship (SEAR) questionnaire is a validated, patient-administered, psychometric instrument specific to ED. OBJECTIVE: To determine correlations between erectile function (EF), intercourse success, and emotional well-being measured with the SEAR questionnaire in men treated with sildenafil citrate for ED and stratified by age (< 50 years, 50-65 years, and > 65 years). RESEARCH DESIGN AND METHODS: This was an open-label, flexible-dose trial of sildenafil (25, 50 and 100 mg) administered for 10 weeks to 382 men with ED (mean +/- SD age, 55 +/- 13 years; mean ED duration, 4 years), which was conducted at 62 centers in the United States. MAIN OUTCOME MEASURES: Analysis (by intent-to-treat, n = 368) of the change from baseline to the week-10 endpoint in the SEAR questionnaire Self-Esteem subscale, the intercourse success rate (percent of occasions at which an erection that lasted long enough for successful intercourse was achieved), and their correlation. RESULTS: For the overall population, there was mean +/- SD improvement (p < 0.0001, paired t-tests) in the Self-Esteem subscale (56 +/- 25 to 79 +/- 22) and intercourse success rate (21 +/- 30% to 70 +/- 36%), which showed positive correlation (p < 0.0001). Secondary outcomes (i.e., EF domain of the International Index of Erectile Function; event log frequency of erection hard enough for sexual intercourse and of ejaculation/orgasm) also improved (p < 0.0001) and correlated positively with the SEAR Self-Esteem subscale and Sexual Relationship domain (p < 0.05 for all correlations). All 10 correlations were positive (p < 0.05) in men aged 50 to 65 years, eight were positive in men aged > 65 years, and six were positive in men aged < 50 years. The most common treatment-related adverse events were mild-to-moderate headache (12% of patients), vasodilatation (7%), and rhinitis (4%). CONCLUSIONS: Men treated with sildenafil for ED demonstrated improved erectile function and an increased intercourse success rate, which correlated positively with improvement in SEAR measures of self-esteem and sexual relationship. SN - 0300-7995 UR - https://www.unboundmedicine.com/medline/citation/16709315/Correlation_of_improved_erectile_function_and_rate_of_successful_intercourse_with_improved_emotional_well_being_assessed_with_the_Self_Esteem_And_Relationship_questionnaire_in_men_treated_with_sildenafil_for_erectile_dysfunction_and_stratified_by_age_ L2 - http://www.tandfonline.com/doi/full/10.1185/030079906X104704 DB - PRIME DP - Unbound Medicine ER -