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Type 2 diabetes in youth from the Western Pacific region: glycaemic control, diabetes care and complications.
Curr Med Res Opin. 2006 May; 22(5):1013-20.CM

Abstract

OBJECTIVE

To describe the glycaemic control, diabetes care and prevalence of complications in youth with type 2 diabetes from the Western Pacific Region.

RESEARCH DESIGN AND METHODS

Cross-sectional, clinic-based audit of 331 patients aged < 18 years from 56 centres in Australia, China-Beijing, China-Shanghai, China-Hong Kong, Indonesia, Japan, South Korea, Malaysia, Philippines, Singapore, Taiwan and Thailand. Clinical and management data were recorded along with glycated haemoglobin (HbA(1c)), lipids and complication rates.

MAIN OUTCOME MEASURES

Glycaemic control, complications, diabetes management.

RESULTS

Median age was 14.9 years (interquartile range 13.2-16.4 years) and median diabetes duration 2.3 years (1.4-3.6 years). Median HbA(1c) was 7% (5.9-9.9%) and HbA(1c) was > 7.5% in 40% of patients. In multiple regression analysis, glycaemic control varied significantly between countries (p = 0.02); higher HbA(1c) was associated with fewer home blood glucose measurements (p = 0.005) and higher insulin dose/kg (p < 0.0001). Blood glucose monitoring was performed by 65% of patients (range 33-96% by country). In 25% of patients, management consisted of diet alone or no treatment (range 0-53% by country); oral anti-diabetic drugs alone were used in 49%, insulin alone in 11% and both in 15%. Microalbuminuria was found in 8% and hypertension in 24%. The risk of hypertension increased with higher BMI (OR 1.16, 95% CI 1.09-1.24, p < 0.0001); antihypertensive agents were used in 4% of patients.

CONCLUSIONS

The management of type 2 diabetes in youth from the Western Pacific Region varies widely. Hypertension and microalbuminuria were frequent, but not commonly treated. Further investigation into the natural history and risk factors for complications in youth with type 2 diabetes is required to assist in developing evidence based management guidelines.

Authors+Show Affiliations

The Children's Hospital at Westmead, Sydney, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16709323

Citation

Eppens, Maike C., et al. "Type 2 Diabetes in Youth From the Western Pacific Region: Glycaemic Control, Diabetes Care and Complications." Current Medical Research and Opinion, vol. 22, no. 5, 2006, pp. 1013-20.
Eppens MC, Craig ME, Jones TW, et al. Type 2 diabetes in youth from the Western Pacific region: glycaemic control, diabetes care and complications. Curr Med Res Opin. 2006;22(5):1013-20.
Eppens, M. C., Craig, M. E., Jones, T. W., Silink, M., Ong, S., & Ping, Y. J. (2006). Type 2 diabetes in youth from the Western Pacific region: glycaemic control, diabetes care and complications. Current Medical Research and Opinion, 22(5), 1013-20.
Eppens MC, et al. Type 2 Diabetes in Youth From the Western Pacific Region: Glycaemic Control, Diabetes Care and Complications. Curr Med Res Opin. 2006;22(5):1013-20. PubMed PMID: 16709323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 2 diabetes in youth from the Western Pacific region: glycaemic control, diabetes care and complications. AU - Eppens,Maike C, AU - Craig,Maria E, AU - Jones,Timothy W, AU - Silink,Martin, AU - Ong,Stephanie, AU - Ping,Yeo Jing, AU - ,, PY - 2006/5/20/pubmed PY - 2006/9/23/medline PY - 2006/5/20/entrez SP - 1013 EP - 20 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 22 IS - 5 N2 - OBJECTIVE: To describe the glycaemic control, diabetes care and prevalence of complications in youth with type 2 diabetes from the Western Pacific Region. RESEARCH DESIGN AND METHODS: Cross-sectional, clinic-based audit of 331 patients aged < 18 years from 56 centres in Australia, China-Beijing, China-Shanghai, China-Hong Kong, Indonesia, Japan, South Korea, Malaysia, Philippines, Singapore, Taiwan and Thailand. Clinical and management data were recorded along with glycated haemoglobin (HbA(1c)), lipids and complication rates. MAIN OUTCOME MEASURES: Glycaemic control, complications, diabetes management. RESULTS: Median age was 14.9 years (interquartile range 13.2-16.4 years) and median diabetes duration 2.3 years (1.4-3.6 years). Median HbA(1c) was 7% (5.9-9.9%) and HbA(1c) was > 7.5% in 40% of patients. In multiple regression analysis, glycaemic control varied significantly between countries (p = 0.02); higher HbA(1c) was associated with fewer home blood glucose measurements (p = 0.005) and higher insulin dose/kg (p < 0.0001). Blood glucose monitoring was performed by 65% of patients (range 33-96% by country). In 25% of patients, management consisted of diet alone or no treatment (range 0-53% by country); oral anti-diabetic drugs alone were used in 49%, insulin alone in 11% and both in 15%. Microalbuminuria was found in 8% and hypertension in 24%. The risk of hypertension increased with higher BMI (OR 1.16, 95% CI 1.09-1.24, p < 0.0001); antihypertensive agents were used in 4% of patients. CONCLUSIONS: The management of type 2 diabetes in youth from the Western Pacific Region varies widely. Hypertension and microalbuminuria were frequent, but not commonly treated. Further investigation into the natural history and risk factors for complications in youth with type 2 diabetes is required to assist in developing evidence based management guidelines. SN - 0300-7995 UR - https://www.unboundmedicine.com/medline/citation/16709323/Type_2_diabetes_in_youth_from_the_Western_Pacific_region:_glycaemic_control_diabetes_care_and_complications_ L2 - https://www.tandfonline.com/doi/full/10.1185/030079906X104795 DB - PRIME DP - Unbound Medicine ER -