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Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study.
Dement Geriatr Cogn Disord 2006; 22(1):99-107DG

Abstract

BACKGROUND

Lifestyle and vascular factors have been linked to dementia and Alzheimer's disease (AD), but the role of dietary fats in the development of dementia is less clear.

METHODS

Participants were derived from random, population-based samples initially studied in midlife (1972, 1977, 1982, or 1987). Fat intake from spreads and milk products was assessed using a structured questionnaire and an interview. After an average follow-up of 21 years, a total of 1,449 (73%) individuals aged 65-80 years participated in the re-examination in 1998. Altogether 117 persons had dementia.

RESULTS

Moderate intake of polyunsaturated fats at midlife decreased the risk of dementia even after adjustment for demographic variables, other subtypes of fats, vascular risk factors and disorders, and apolipoprotein E (ApoE) genotype (OR 0.40, CI 0.17-0.94 for the 2nd quartile vs. 1st quartile), whereas saturated fat intake was associated with an increased risk (OR 2.45, CI 1.10-5.47 for the 2nd quartile). The associations were seen only among the ApoE epsilon4 carriers.

CONCLUSIONS

Moderate intake of unsaturated fats at midlife is protective, whereas a moderate intake of saturated fats may increase the risk of dementia and AD, especially among ApoE epsilon4 carriers. Thus, dietary interventions may potentially modify the risk of dementia, particularly among genetically susceptible individuals.

Authors+Show Affiliations

Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16710090

Citation

Laitinen, M H., et al. "Fat Intake at Midlife and Risk of Dementia and Alzheimer's Disease: a Population-based Study." Dementia and Geriatric Cognitive Disorders, vol. 22, no. 1, 2006, pp. 99-107.
Laitinen MH, Ngandu T, Rovio S, et al. Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study. Dement Geriatr Cogn Disord. 2006;22(1):99-107.
Laitinen, M. H., Ngandu, T., Rovio, S., Helkala, E. L., Uusitalo, U., Viitanen, M., ... Kivipelto, M. (2006). Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study. Dementia and Geriatric Cognitive Disorders, 22(1), pp. 99-107.
Laitinen MH, et al. Fat Intake at Midlife and Risk of Dementia and Alzheimer's Disease: a Population-based Study. Dement Geriatr Cogn Disord. 2006;22(1):99-107. PubMed PMID: 16710090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study. AU - Laitinen,M H, AU - Ngandu,T, AU - Rovio,S, AU - Helkala,E-L, AU - Uusitalo,U, AU - Viitanen,M, AU - Nissinen,A, AU - Tuomilehto,J, AU - Soininen,H, AU - Kivipelto,M, Y1 - 2006/05/19/ PY - 2005/12/20/accepted PY - 2006/5/20/pubmed PY - 2006/8/19/medline PY - 2006/5/20/entrez SP - 99 EP - 107 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 22 IS - 1 N2 - BACKGROUND: Lifestyle and vascular factors have been linked to dementia and Alzheimer's disease (AD), but the role of dietary fats in the development of dementia is less clear. METHODS: Participants were derived from random, population-based samples initially studied in midlife (1972, 1977, 1982, or 1987). Fat intake from spreads and milk products was assessed using a structured questionnaire and an interview. After an average follow-up of 21 years, a total of 1,449 (73%) individuals aged 65-80 years participated in the re-examination in 1998. Altogether 117 persons had dementia. RESULTS: Moderate intake of polyunsaturated fats at midlife decreased the risk of dementia even after adjustment for demographic variables, other subtypes of fats, vascular risk factors and disorders, and apolipoprotein E (ApoE) genotype (OR 0.40, CI 0.17-0.94 for the 2nd quartile vs. 1st quartile), whereas saturated fat intake was associated with an increased risk (OR 2.45, CI 1.10-5.47 for the 2nd quartile). The associations were seen only among the ApoE epsilon4 carriers. CONCLUSIONS: Moderate intake of unsaturated fats at midlife is protective, whereas a moderate intake of saturated fats may increase the risk of dementia and AD, especially among ApoE epsilon4 carriers. Thus, dietary interventions may potentially modify the risk of dementia, particularly among genetically susceptible individuals. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/16710090/Fat_intake_at_midlife_and_risk_of_dementia_and_Alzheimer's_disease:_a_population_based_study_ L2 - https://www.karger.com?DOI=10.1159/000093478 DB - PRIME DP - Unbound Medicine ER -