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Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: evidence from spectral analysis of heart rate variability.
Clin Endocrinol (Oxf). 2006 Jun; 64(6):611-6.CE

Abstract

OBJECTIVE

The clinical manifestations of hyperthyroidism resemble those of the hyperadrenergic state. This study was designed to evaluate the impact of hyperthyroidism on the autonomic nervous system (ANS) and to investigate the relationship between serum thyroid hormone concentrations and parameters of spectral heart rate variability (HRV) analysis in hyperthyroidism.

DESIGN AND PATIENTS

Thirty-two hyperthyroid Graves' disease patients (mean age 31 years) and 32 sex-, age-, and body mass index (BMI)-matched normal control subjects were recruited to receive one-channel electrocardiogram (ECG) recording.

MEASUREMENTS

The cardiac autonomic nervous function was evaluated by the spectral analysis of HRV, which indicates the autonomic modulation of the sinus node. The correlation coefficients between serum thyroid hormone concentrations and parameters of the spectral HRV analysis were also computed.

RESULTS

The hyperthyroid patients revealed significant differences (P < 0.001) compared with the controls in the following HRV parameters: a decrease in total power (TP), very low frequency power (VLF), low frequency power (LF), high frequency power (HF), and HF in normalized units (HF%); and an increase in LF in normalized units (LF%) and in the ratio of LF to HF (LF/HF). After correction of hyperthyroidism in 28 patients, all of the above parameters were restored to levels comparable to those of the controls. In addition, serum thyroid hormone concentrations showed significant correlations with spectral HRV parameters.

CONCLUSIONS

Hyperthyroidism is in a sympathovagal imbalanced state, characterized by both increased sympathetic and decreased vagal modulation of the heart rate. These autonomic dysfunctions can be detected simultaneously by spectral analysis of HRV, and the spectral HRV parameters could reflect the disease severity in hyperthyroid patients.

Authors+Show Affiliations

Chen JL
Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan.
Chiu HW
No affiliation info available
Tseng YJ
No affiliation info available
Chu WC
No affiliation info available

MeSH

AdultAntithyroid AgentsAutonomic Nervous SystemCase-Control StudiesElectrocardiography, AmbulatoryFemaleGraves DiseaseHeart RateHumansHyperthyroidismMaleParasympathetic Nervous SystemSignal Processing, Computer-AssistedStatistics, NonparametricThyrotropinThyroxineTriiodothyronine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16712661

Citation

Chen, Jin-Long, et al. "Hyperthyroidism Is Characterized By Both Increased Sympathetic and Decreased Vagal Modulation of Heart Rate: Evidence From Spectral Analysis of Heart Rate Variability." Clinical Endocrinology, vol. 64, no. 6, 2006, pp. 611-6.
Chen JL, Chiu HW, Tseng YJ, et al. Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: evidence from spectral analysis of heart rate variability. Clin Endocrinol (Oxf). 2006;64(6):611-6.
Chen, J. L., Chiu, H. W., Tseng, Y. J., & Chu, W. C. (2006). Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: evidence from spectral analysis of heart rate variability. Clinical Endocrinology, 64(6), 611-6.
Chen JL, et al. Hyperthyroidism Is Characterized By Both Increased Sympathetic and Decreased Vagal Modulation of Heart Rate: Evidence From Spectral Analysis of Heart Rate Variability. Clin Endocrinol (Oxf). 2006;64(6):611-6. PubMed PMID: 16712661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: evidence from spectral analysis of heart rate variability. AU - Chen,Jin-Long, AU - Chiu,Hung-Wen, AU - Tseng,Yin-Jiun, AU - Chu,Woei-Chyn, PY - 2006/5/23/pubmed PY - 2006/9/16/medline PY - 2006/5/23/entrez SP - 611 EP - 6 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 64 IS - 6 N2 - OBJECTIVE: The clinical manifestations of hyperthyroidism resemble those of the hyperadrenergic state. This study was designed to evaluate the impact of hyperthyroidism on the autonomic nervous system (ANS) and to investigate the relationship between serum thyroid hormone concentrations and parameters of spectral heart rate variability (HRV) analysis in hyperthyroidism. DESIGN AND PATIENTS: Thirty-two hyperthyroid Graves' disease patients (mean age 31 years) and 32 sex-, age-, and body mass index (BMI)-matched normal control subjects were recruited to receive one-channel electrocardiogram (ECG) recording. MEASUREMENTS: The cardiac autonomic nervous function was evaluated by the spectral analysis of HRV, which indicates the autonomic modulation of the sinus node. The correlation coefficients between serum thyroid hormone concentrations and parameters of the spectral HRV analysis were also computed. RESULTS: The hyperthyroid patients revealed significant differences (P < 0.001) compared with the controls in the following HRV parameters: a decrease in total power (TP), very low frequency power (VLF), low frequency power (LF), high frequency power (HF), and HF in normalized units (HF%); and an increase in LF in normalized units (LF%) and in the ratio of LF to HF (LF/HF). After correction of hyperthyroidism in 28 patients, all of the above parameters were restored to levels comparable to those of the controls. In addition, serum thyroid hormone concentrations showed significant correlations with spectral HRV parameters. CONCLUSIONS: Hyperthyroidism is in a sympathovagal imbalanced state, characterized by both increased sympathetic and decreased vagal modulation of the heart rate. These autonomic dysfunctions can be detected simultaneously by spectral analysis of HRV, and the spectral HRV parameters could reflect the disease severity in hyperthyroid patients. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16712661/Hyperthyroidism_is_characterized_by_both_increased_sympathetic_and_decreased_vagal_modulation_of_heart_rate:_evidence_from_spectral_analysis_of_heart_rate_variability_ DB - PRIME DP - Unbound Medicine ER -