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Plasma ghrelin levels of gastrectomized and vagotomized patients are not affected by glucose administration.
Clin Endocrinol (Oxf) 2006; 64(6):684-8CE

Abstract

BACKGROUND

Ghrelin is a brain-gut peptide with GH-releasing and appetite-inducing activities, secreted mainly by the stomach. Circulating ghrelin concentrations fall rapidly after nutrient ingestion as well as after oral and intravenous glucose challenge. A number of gut hormones including ghrelin require an intact vagal system, which has been hypothesized to have a major role in initiating the postprandial fall in ghrelin levels.

AIM

We aimed to investigate the effect of oral glucose challenge on ghrelin secretion in gastrectomized (GASTRX) and vagotomized patients.

DESIGN

Interventional study.

PATIENTS

Six GASTRX-vagotomized patients and 11 healthy sex- and body mass index (BMI)-matched subjects.

METHODS

An oral glucose tolerance test (OGTT) was performed in all subjects. At baseline, circulating plasma total ghrelin, serum glucose, insulin and GH levels were measured. Serum glucose, insulin, GH and plasma ghrelin levels were determined every 30 min for 2 h.

RESULTS

Plasma ghrelin levels at baseline were reduced by 55% in GASTRX-vagotomized patients compared to the control group (P < 0.01). In control subjects, plasma ghrelin levels decreased significantly during the OGTT whereas in GASTRX-vagotomized patients no reduction was registered (26.4 +/- 2.8% vs. 5.5 +/- 3.4%). The OGTT revealed a significantly greater increase in circulating glucose levels and serum insulin levels while GH response was not different in GASTRX-vagotomized patients compared to control subjects.

CONCLUSIONS

Our data show that circulating ghrelin levels in GASTRX and vagotomized patients were not suppressed after oral glucose administration, unlike control subjects, suggesting that this effect could be due, at least in part, to the lack of contribution of the vagal nervous system to the regulation of ghrelin.

Authors+Show Affiliations

Institute of Endocrinology, Diabetes and Metabolism, University Clinical Centre, Belgrade, Serbia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16712672

Citation

Pekic, S, et al. "Plasma Ghrelin Levels of Gastrectomized and Vagotomized Patients Are Not Affected By Glucose Administration." Clinical Endocrinology, vol. 64, no. 6, 2006, pp. 684-8.
Pekic S, Pesko P, Djurovic M, et al. Plasma ghrelin levels of gastrectomized and vagotomized patients are not affected by glucose administration. Clin Endocrinol (Oxf). 2006;64(6):684-8.
Pekic, S., Pesko, P., Djurovic, M., Miljic, D., Doknic, M., Glodic, J., ... Popovic, V. (2006). Plasma ghrelin levels of gastrectomized and vagotomized patients are not affected by glucose administration. Clinical Endocrinology, 64(6), pp. 684-8.
Pekic S, et al. Plasma Ghrelin Levels of Gastrectomized and Vagotomized Patients Are Not Affected By Glucose Administration. Clin Endocrinol (Oxf). 2006;64(6):684-8. PubMed PMID: 16712672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma ghrelin levels of gastrectomized and vagotomized patients are not affected by glucose administration. AU - Pekic,S, AU - Pesko,P, AU - Djurovic,M, AU - Miljic,D, AU - Doknic,M, AU - Glodic,J, AU - Dieguez,C, AU - Casanueva,F F, AU - Popovic,V, PY - 2006/5/23/pubmed PY - 2006/9/16/medline PY - 2006/5/23/entrez SP - 684 EP - 8 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 64 IS - 6 N2 - BACKGROUND: Ghrelin is a brain-gut peptide with GH-releasing and appetite-inducing activities, secreted mainly by the stomach. Circulating ghrelin concentrations fall rapidly after nutrient ingestion as well as after oral and intravenous glucose challenge. A number of gut hormones including ghrelin require an intact vagal system, which has been hypothesized to have a major role in initiating the postprandial fall in ghrelin levels. AIM: We aimed to investigate the effect of oral glucose challenge on ghrelin secretion in gastrectomized (GASTRX) and vagotomized patients. DESIGN: Interventional study. PATIENTS: Six GASTRX-vagotomized patients and 11 healthy sex- and body mass index (BMI)-matched subjects. METHODS: An oral glucose tolerance test (OGTT) was performed in all subjects. At baseline, circulating plasma total ghrelin, serum glucose, insulin and GH levels were measured. Serum glucose, insulin, GH and plasma ghrelin levels were determined every 30 min for 2 h. RESULTS: Plasma ghrelin levels at baseline were reduced by 55% in GASTRX-vagotomized patients compared to the control group (P < 0.01). In control subjects, plasma ghrelin levels decreased significantly during the OGTT whereas in GASTRX-vagotomized patients no reduction was registered (26.4 +/- 2.8% vs. 5.5 +/- 3.4%). The OGTT revealed a significantly greater increase in circulating glucose levels and serum insulin levels while GH response was not different in GASTRX-vagotomized patients compared to control subjects. CONCLUSIONS: Our data show that circulating ghrelin levels in GASTRX and vagotomized patients were not suppressed after oral glucose administration, unlike control subjects, suggesting that this effect could be due, at least in part, to the lack of contribution of the vagal nervous system to the regulation of ghrelin. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16712672/Plasma_ghrelin_levels_of_gastrectomized_and_vagotomized_patients_are_not_affected_by_glucose_administration_ L2 - https://doi.org/10.1111/j.1365-2265.2006.02528.x DB - PRIME DP - Unbound Medicine ER -