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Are low doses of tritium genotoxic to Mytilus edulis?
Mar Environ Res. 2006 Jul; 62 Suppl:S297-300.ME

Abstract

The genotoxic effects of tritium (3H) in the adult life stage of Mytilus edulis have been evaluated by the induction of micronuclei (MN) and DNA single strand breaks/alkali labile sites (Comet assay) in the haemocytes of exposed individuals. Assays were optimised and validated using ethylmethane sulfonate (EMS) as a reference genotoxic agent over different exposure periods. M. edulis were exposed, for 96 h, to a range of concentrations of 3H equivalent to a dose range of 12-485 microGy h(-1). Results revealed a dose-dependent increase for both the MN and Comet assays, and for both EMS and 3H. Since less than 500 microGy h(-1) 3H is capable of inducing genetic damage, generic doses recommended by the IAEA for the protection of aquatic biota may be overestimated for some organisms.

Authors+Show Affiliations

School of Biological Sciences, University of Plymouth, Plymouth PL4 8AA, UK. a.jha@plymouth.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16712917

Citation

Jha, Awadhesh N., et al. "Are Low Doses of Tritium Genotoxic to Mytilus Edulis?" Marine Environmental Research, vol. 62 Suppl, 2006, pp. S297-300.
Jha AN, Dogra Y, Turner A, et al. Are low doses of tritium genotoxic to Mytilus edulis? Mar Environ Res. 2006;62 Suppl:S297-300.
Jha, A. N., Dogra, Y., Turner, A., & Millward, G. E. (2006). Are low doses of tritium genotoxic to Mytilus edulis? Marine Environmental Research, 62 Suppl, S297-300.
Jha AN, et al. Are Low Doses of Tritium Genotoxic to Mytilus Edulis. Mar Environ Res. 2006;62 Suppl:S297-300. PubMed PMID: 16712917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are low doses of tritium genotoxic to Mytilus edulis? AU - Jha,Awadhesh N, AU - Dogra,Yuktee, AU - Turner,Andrew, AU - Millward,Geoffrey E, Y1 - 2006/04/18/ PY - 2006/5/23/pubmed PY - 2008/2/22/medline PY - 2006/5/23/entrez SP - S297 EP - 300 JF - Marine environmental research JO - Mar Environ Res VL - 62 Suppl N2 - The genotoxic effects of tritium (3H) in the adult life stage of Mytilus edulis have been evaluated by the induction of micronuclei (MN) and DNA single strand breaks/alkali labile sites (Comet assay) in the haemocytes of exposed individuals. Assays were optimised and validated using ethylmethane sulfonate (EMS) as a reference genotoxic agent over different exposure periods. M. edulis were exposed, for 96 h, to a range of concentrations of 3H equivalent to a dose range of 12-485 microGy h(-1). Results revealed a dose-dependent increase for both the MN and Comet assays, and for both EMS and 3H. Since less than 500 microGy h(-1) 3H is capable of inducing genetic damage, generic doses recommended by the IAEA for the protection of aquatic biota may be overestimated for some organisms. SN - 0141-1136 UR - https://www.unboundmedicine.com/medline/citation/16712917/Are_low_doses_of_tritium_genotoxic_to_Mytilus_edulis L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-1136(06)00079-1 DB - PRIME DP - Unbound Medicine ER -