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Analyses of a MS-associated haplotype encompassing the CCL3 gene.
J Neuroimmunol 2006; 176(1-2):216-8JN

Abstract

Our previous studies showed the association of multiple sclerosis with the same marker haplotype encompassing the CCL3 gene in two independent sets of families. Here we present that sequencing of this haplotype and its flanking regions detected no new mutation, but 16 single nucleotide polymorphisms (SNP) and 1 insertion/deletion variant in both affected and unaffected individuals. Transmission distortion analyses of the newly identified variants in the second set of families revealed no individual marker association. In the absence of a single disease relevant variant within the MS associated haplotype and the surrounding linkage disequilibrium block, the highlighted haplotype may itself indicate a functionally relevant allelic combination or interaction.

Authors+Show Affiliations

Department of Neurology, Saint Luke's Roosevelt Hospital Center, Columbia University, 432W 58th Street, Room 226, New York, NY 10019, United States.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16712957

Citation

Vyshkina, Tamara, and Bernadette Kalman. "Analyses of a MS-associated Haplotype Encompassing the CCL3 Gene." Journal of Neuroimmunology, vol. 176, no. 1-2, 2006, pp. 216-8.
Vyshkina T, Kalman B. Analyses of a MS-associated haplotype encompassing the CCL3 gene. J Neuroimmunol. 2006;176(1-2):216-8.
Vyshkina, T., & Kalman, B. (2006). Analyses of a MS-associated haplotype encompassing the CCL3 gene. Journal of Neuroimmunology, 176(1-2), pp. 216-8.
Vyshkina T, Kalman B. Analyses of a MS-associated Haplotype Encompassing the CCL3 Gene. J Neuroimmunol. 2006;176(1-2):216-8. PubMed PMID: 16712957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analyses of a MS-associated haplotype encompassing the CCL3 gene. AU - Vyshkina,Tamara, AU - Kalman,Bernadette, Y1 - 2006/05/19/ PY - 2005/11/23/received PY - 2006/03/21/revised PY - 2006/03/27/accepted PY - 2006/5/23/pubmed PY - 2006/9/30/medline PY - 2006/5/23/entrez SP - 216 EP - 8 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 176 IS - 1-2 N2 - Our previous studies showed the association of multiple sclerosis with the same marker haplotype encompassing the CCL3 gene in two independent sets of families. Here we present that sequencing of this haplotype and its flanking regions detected no new mutation, but 16 single nucleotide polymorphisms (SNP) and 1 insertion/deletion variant in both affected and unaffected individuals. Transmission distortion analyses of the newly identified variants in the second set of families revealed no individual marker association. In the absence of a single disease relevant variant within the MS associated haplotype and the surrounding linkage disequilibrium block, the highlighted haplotype may itself indicate a functionally relevant allelic combination or interaction. SN - 0165-5728 UR - https://www.unboundmedicine.com/medline/citation/16712957/Analyses_of_a_MS_associated_haplotype_encompassing_the_CCL3_gene_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(06)00121-4 DB - PRIME DP - Unbound Medicine ER -