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Trans fatty acids and insulin resistance.
Atheroscler Suppl. 2006 May; 7(2):37-9.AS

Abstract

Since trans fatty acids (TFA) might interfere with cell membrane functions, there are reasons to believe that high TFA intakes could affect insulin sensitivity and consequently diabetes risk. It is possible that low amounts of TFA consumed during long time-periods might be clinically relevant. Data from controlled intervention studies investigating the effects of TFA on insulin sensitivity are reviewed. The results show no significant effect of TFA on insulin sensitivity in lean healthy subjects. However, there is some evidence that TFA could impair insulin sensitivity compared to unsaturated fat in insulin resistant or diabetic individuals. This is especially true for conjugated TFA, i.e. conjugated linoleic acid (CLA), which clearly impairs insulin sensitivity. In fact, the effect of CLA on insulin action is the most dramatic adverse effect described for a dietary fatty acid. The inconsistent effect of TFA as a group might partly be due to methodological limitations (e.g. few studies, short duration or small sample size) and differences between studies in design, type and amount of TFA used. Large controlled trials have been required to demonstrate adverse effects of saturated fat on insulin sensitivity, and similar efforts will probably be needed to clarify the effect of TFA on insulin sensitivity.

Authors+Show Affiliations

Clinical Nutrition and Metabolism, Uppsala University, Faculty of Medicine, Sweden. ulf.riserus@pubcare.uu.se

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

16713388

Citation

Risérus, Ulf. "Trans Fatty Acids and Insulin Resistance." Atherosclerosis. Supplements, vol. 7, no. 2, 2006, pp. 37-9.
Risérus U. Trans fatty acids and insulin resistance. Atheroscler Suppl. 2006;7(2):37-9.
Risérus, U. (2006). Trans fatty acids and insulin resistance. Atherosclerosis. Supplements, 7(2), 37-9.
Risérus U. Trans Fatty Acids and Insulin Resistance. Atheroscler Suppl. 2006;7(2):37-9. PubMed PMID: 16713388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trans fatty acids and insulin resistance. A1 - Risérus,Ulf, Y1 - 2006/05/18/ PY - 2006/5/23/pubmed PY - 2006/11/15/medline PY - 2006/5/23/entrez SP - 37 EP - 9 JF - Atherosclerosis. Supplements JO - Atheroscler Suppl VL - 7 IS - 2 N2 - Since trans fatty acids (TFA) might interfere with cell membrane functions, there are reasons to believe that high TFA intakes could affect insulin sensitivity and consequently diabetes risk. It is possible that low amounts of TFA consumed during long time-periods might be clinically relevant. Data from controlled intervention studies investigating the effects of TFA on insulin sensitivity are reviewed. The results show no significant effect of TFA on insulin sensitivity in lean healthy subjects. However, there is some evidence that TFA could impair insulin sensitivity compared to unsaturated fat in insulin resistant or diabetic individuals. This is especially true for conjugated TFA, i.e. conjugated linoleic acid (CLA), which clearly impairs insulin sensitivity. In fact, the effect of CLA on insulin action is the most dramatic adverse effect described for a dietary fatty acid. The inconsistent effect of TFA as a group might partly be due to methodological limitations (e.g. few studies, short duration or small sample size) and differences between studies in design, type and amount of TFA used. Large controlled trials have been required to demonstrate adverse effects of saturated fat on insulin sensitivity, and similar efforts will probably be needed to clarify the effect of TFA on insulin sensitivity. SN - 1567-5688 UR - https://www.unboundmedicine.com/medline/citation/16713388/Trans_fatty_acids_and_insulin_resistance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5688(06)00034-1 DB - PRIME DP - Unbound Medicine ER -