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Immune response to influenza vaccination in community-dwelling Chinese elderly persons.
Vaccine 2006; 24(25):5371-80V

Abstract

We investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre>or=1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p=0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI>or=40) were independent predictors of a decreased risk of hospitalizations.

Authors+Show Affiliations

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16713661

Citation

Hui, S L., et al. "Immune Response to Influenza Vaccination in Community-dwelling Chinese Elderly Persons." Vaccine, vol. 24, no. 25, 2006, pp. 5371-80.
Hui SL, Chu LW, Peiris JS, et al. Immune response to influenza vaccination in community-dwelling Chinese elderly persons. Vaccine. 2006;24(25):5371-80.
Hui, S. L., Chu, L. W., Peiris, J. S., Chan, K. H., Chu, D., & Tsui, W. (2006). Immune response to influenza vaccination in community-dwelling Chinese elderly persons. Vaccine, 24(25), pp. 5371-80.
Hui SL, et al. Immune Response to Influenza Vaccination in Community-dwelling Chinese Elderly Persons. Vaccine. 2006 Jun 19;24(25):5371-80. PubMed PMID: 16713661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune response to influenza vaccination in community-dwelling Chinese elderly persons. AU - Hui,S L, AU - Chu,L W, AU - Peiris,J S M, AU - Chan,K H, AU - Chu,D, AU - Tsui,W, Y1 - 2006/05/03/ PY - 2005/08/17/received PY - 2006/04/07/revised PY - 2006/04/25/accepted PY - 2006/5/23/pubmed PY - 2006/8/17/medline PY - 2006/5/23/entrez SP - 5371 EP - 80 JF - Vaccine JO - Vaccine VL - 24 IS - 25 N2 - We investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre>or=1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p=0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI>or=40) were independent predictors of a decreased risk of hospitalizations. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/16713661/Immune_response_to_influenza_vaccination_in_community_dwelling_Chinese_elderly_persons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(06)00482-8 DB - PRIME DP - Unbound Medicine ER -