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Immune response to influenza vaccination in community-dwelling Chinese elderly persons.

Abstract

We investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre>or=1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p=0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI>or=40) were independent predictors of a decreased risk of hospitalizations.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong.

    , , , ,

    Source

    Vaccine 24:25 2006 Jun 19 pg 5371-80

    MeSH

    Aged
    Aged, 80 and over
    Antibodies, Viral
    Female
    Hemagglutination Inhibition Tests
    Hong Kong
    Humans
    Immunization Schedule
    Influenza A Virus, H1N1 Subtype
    Influenza A Virus, H3N2 Subtype
    Influenza Vaccines
    Influenza, Human
    Male
    Residence Characteristics
    Vaccination

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16713661

    Citation

    Hui, S L., et al. "Immune Response to Influenza Vaccination in Community-dwelling Chinese Elderly Persons." Vaccine, vol. 24, no. 25, 2006, pp. 5371-80.
    Hui SL, Chu LW, Peiris JS, et al. Immune response to influenza vaccination in community-dwelling Chinese elderly persons. Vaccine. 2006;24(25):5371-80.
    Hui, S. L., Chu, L. W., Peiris, J. S., Chan, K. H., Chu, D., & Tsui, W. (2006). Immune response to influenza vaccination in community-dwelling Chinese elderly persons. Vaccine, 24(25), pp. 5371-80.
    Hui SL, et al. Immune Response to Influenza Vaccination in Community-dwelling Chinese Elderly Persons. Vaccine. 2006 Jun 19;24(25):5371-80. PubMed PMID: 16713661.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Immune response to influenza vaccination in community-dwelling Chinese elderly persons. AU - Hui,S L, AU - Chu,L W, AU - Peiris,J S M, AU - Chan,K H, AU - Chu,D, AU - Tsui,W, Y1 - 2006/05/03/ PY - 2005/08/17/received PY - 2006/04/07/revised PY - 2006/04/25/accepted PY - 2006/5/23/pubmed PY - 2006/8/17/medline PY - 2006/5/23/entrez SP - 5371 EP - 80 JF - Vaccine JO - Vaccine VL - 24 IS - 25 N2 - We investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre>or=1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p=0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI>or=40) were independent predictors of a decreased risk of hospitalizations. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/16713661/Immune_response_to_influenza_vaccination_in_community_dwelling_Chinese_elderly_persons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(06)00482-8 DB - PRIME DP - Unbound Medicine ER -