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The relationship between homeostasis model assessment and cardiovascular risk factors in Iranian subjects with normal fasting glucose and normal glucose tolerance.
Clin Chim Acta. 2006 Sep; 371(1-2):169-75.CC

Abstract

BACKGROUND

Insulin resistance is a complex problem which may not always correlate with all its cardiovascular risk factors in various populations. We investigated the relationship between homeostasis model assessment of insulin resistance (HOMA-IR) with cardiovascular risk factors in Iranian subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT).

METHODS

Of the 605 subjects aged 25-79 y enrolled in this study, after the oral glucose tolerance test, 366 subjects aged 25-50 y and 135 aged >50 y were classified as NFG and NGT. Insulin resistance was estimated by the HOMA-IR.

RESULTS

Women had higher values of body mass index (BMI), insulin and HOMA-IR than men in both age groups. The prevalence of insulin resistance, general and abdominal obesity, low HDL-C and physical inactivity was higher in women than men in the 2 age groups. Men had a higher prevalence of hypertension and hypertriglyceridemia in the group with age 25-50 y. The Pearson correlation controlled for age, BMI, waist circumference and physical activity showed that HOMA-IR had significant correlation with triglyceride and inversely associated with HDL-C in both sexes. In addition, the results of HOMA-IR quartiles demonstrated that the prevalence of hypertension, obesity, and low HDL-C was particular high in women with HOMA-IR >2.39. Multiple regression indicated that log HOMA-IR was independently predicted by BMI, triglyceride and HDL-C in men and BMI, HDL-C and waist-to-hip (WHR) ratio in women.

CONCLUSIONS

HOMA-IR is associated with the features of metabolic syndrome with a sex difference in the degree and predictors of HOMA-IR and the frequency of cardiovascular risk factors.

Authors+Show Affiliations

Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran. rmeshkani@gmail.com <rmeshkani@gmail.com>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16714005

Citation

Meshkani, Reza, et al. "The Relationship Between Homeostasis Model Assessment and Cardiovascular Risk Factors in Iranian Subjects With Normal Fasting Glucose and Normal Glucose Tolerance." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 371, no. 1-2, 2006, pp. 169-75.
Meshkani R, Taghikhani M, Larijani B, et al. The relationship between homeostasis model assessment and cardiovascular risk factors in Iranian subjects with normal fasting glucose and normal glucose tolerance. Clin Chim Acta. 2006;371(1-2):169-75.
Meshkani, R., Taghikhani, M., Larijani, B., Khatami, S., Khoshbin, E., & Adeli, K. (2006). The relationship between homeostasis model assessment and cardiovascular risk factors in Iranian subjects with normal fasting glucose and normal glucose tolerance. Clinica Chimica Acta; International Journal of Clinical Chemistry, 371(1-2), 169-75.
Meshkani R, et al. The Relationship Between Homeostasis Model Assessment and Cardiovascular Risk Factors in Iranian Subjects With Normal Fasting Glucose and Normal Glucose Tolerance. Clin Chim Acta. 2006;371(1-2):169-75. PubMed PMID: 16714005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between homeostasis model assessment and cardiovascular risk factors in Iranian subjects with normal fasting glucose and normal glucose tolerance. AU - Meshkani,Reza, AU - Taghikhani,Mohammad, AU - Larijani,Bagher, AU - Khatami,Shohreh, AU - Khoshbin,Ehteram, AU - Adeli,Khosrow, Y1 - 2006/05/22/ PY - 2006/02/08/received PY - 2006/03/04/revised PY - 2006/03/06/accepted PY - 2006/5/23/pubmed PY - 2006/9/30/medline PY - 2006/5/23/entrez SP - 169 EP - 75 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 371 IS - 1-2 N2 - BACKGROUND: Insulin resistance is a complex problem which may not always correlate with all its cardiovascular risk factors in various populations. We investigated the relationship between homeostasis model assessment of insulin resistance (HOMA-IR) with cardiovascular risk factors in Iranian subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT). METHODS: Of the 605 subjects aged 25-79 y enrolled in this study, after the oral glucose tolerance test, 366 subjects aged 25-50 y and 135 aged >50 y were classified as NFG and NGT. Insulin resistance was estimated by the HOMA-IR. RESULTS: Women had higher values of body mass index (BMI), insulin and HOMA-IR than men in both age groups. The prevalence of insulin resistance, general and abdominal obesity, low HDL-C and physical inactivity was higher in women than men in the 2 age groups. Men had a higher prevalence of hypertension and hypertriglyceridemia in the group with age 25-50 y. The Pearson correlation controlled for age, BMI, waist circumference and physical activity showed that HOMA-IR had significant correlation with triglyceride and inversely associated with HDL-C in both sexes. In addition, the results of HOMA-IR quartiles demonstrated that the prevalence of hypertension, obesity, and low HDL-C was particular high in women with HOMA-IR >2.39. Multiple regression indicated that log HOMA-IR was independently predicted by BMI, triglyceride and HDL-C in men and BMI, HDL-C and waist-to-hip (WHR) ratio in women. CONCLUSIONS: HOMA-IR is associated with the features of metabolic syndrome with a sex difference in the degree and predictors of HOMA-IR and the frequency of cardiovascular risk factors. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/16714005/The_relationship_between_homeostasis_model_assessment_and_cardiovascular_risk_factors_in_Iranian_subjects_with_normal_fasting_glucose_and_normal_glucose_tolerance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(06)00168-9 DB - PRIME DP - Unbound Medicine ER -