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Combat veterans show normal discrimination during differential trace eyeblink conditioning, but increased responsivity to the conditioned and unconditioned stimulus.
J Psychiatr Res. 2007 Nov; 41(9):785-94.JP

Abstract

The question addressed in the present study was whether post-traumatic stress disorder (PTSD) results in associative learning impairments. To answer this question, differential trace eyeblink (EB) conditioning was studied in combat veterans with PTSD, combat veterans without PTSD, and non-combat veterans without PTSD. Veterans with PTSD showed normal EB discrimination, suggesting that associative learning is not impaired by PTSD. Veterans with PTSD also showed normal extinction. However, subjects with PTSD showed more EB conditioned responses (CRs), as well as increased CR amplitude. Increased response amplitude to the airpuff unconditioned stimulus presented alone (viz. the unconditioned response), as well as to the airpuff on CS+ trials during conditioning also occurred in the subjects with PTSD. These findings suggest increased reactivity in combat veterans with PTSD, compared to those without PTSD, but such heightened reactivity does not affect somatomotor associative learning.

Authors+Show Affiliations

Shirley L. Buchanan Neuroscience Laboratory (151A), Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC 29209, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16716352

Citation

Burriss, Louisa, et al. "Combat Veterans Show Normal Discrimination During Differential Trace Eyeblink Conditioning, but Increased Responsivity to the Conditioned and Unconditioned Stimulus." Journal of Psychiatric Research, vol. 41, no. 9, 2007, pp. 785-94.
Burriss L, Ayers E, Powell DA. Combat veterans show normal discrimination during differential trace eyeblink conditioning, but increased responsivity to the conditioned and unconditioned stimulus. J Psychiatr Res. 2007;41(9):785-94.
Burriss, L., Ayers, E., & Powell, D. A. (2007). Combat veterans show normal discrimination during differential trace eyeblink conditioning, but increased responsivity to the conditioned and unconditioned stimulus. Journal of Psychiatric Research, 41(9), 785-94.
Burriss L, Ayers E, Powell DA. Combat Veterans Show Normal Discrimination During Differential Trace Eyeblink Conditioning, but Increased Responsivity to the Conditioned and Unconditioned Stimulus. J Psychiatr Res. 2007;41(9):785-94. PubMed PMID: 16716352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combat veterans show normal discrimination during differential trace eyeblink conditioning, but increased responsivity to the conditioned and unconditioned stimulus. AU - Burriss,Louisa, AU - Ayers,Edwin, AU - Powell,D A, Y1 - 2006/05/22/ PY - 2005/05/17/received PY - 2006/03/30/revised PY - 2006/04/04/accepted PY - 2006/5/24/pubmed PY - 2007/8/4/medline PY - 2006/5/24/entrez SP - 785 EP - 94 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 41 IS - 9 N2 - The question addressed in the present study was whether post-traumatic stress disorder (PTSD) results in associative learning impairments. To answer this question, differential trace eyeblink (EB) conditioning was studied in combat veterans with PTSD, combat veterans without PTSD, and non-combat veterans without PTSD. Veterans with PTSD showed normal EB discrimination, suggesting that associative learning is not impaired by PTSD. Veterans with PTSD also showed normal extinction. However, subjects with PTSD showed more EB conditioned responses (CRs), as well as increased CR amplitude. Increased response amplitude to the airpuff unconditioned stimulus presented alone (viz. the unconditioned response), as well as to the airpuff on CS+ trials during conditioning also occurred in the subjects with PTSD. These findings suggest increased reactivity in combat veterans with PTSD, compared to those without PTSD, but such heightened reactivity does not affect somatomotor associative learning. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/16716352/Combat_veterans_show_normal_discrimination_during_differential_trace_eyeblink_conditioning_but_increased_responsivity_to_the_conditioned_and_unconditioned_stimulus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(06)00069-0 DB - PRIME DP - Unbound Medicine ER -