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Pattern differentiation of excitatory and inhibitory synaptic inputs on distinct neuronal types in the rat caudal nucleus of the tractus solitarius.
Neurosci Res. 2006 Jul; 55(3):300-15.NR

Abstract

Region- and size-specific neuronal organizations of the caudal nucleus of the tractus solitarius (cNTS) were investigated, followed by analyses of excitatory and inhibitory synaptic input patterns onto specific cell types by patch clamp recordings and immunoelectron microscopy. Cell size distribution and numerical density of cNTS neurons were examined in subregions at levels of the area postrema. In the subpostremal and dorsomedial subnuclei, characterized by the presence of dense glutamatergic and sparse GABAergic somata, small calbindin neurons constituted 42% of the total cells. The medial subnucleus contained large numbers of glutamatergic, GABAergic, and catecholaminergic somata and large tyrosine hydroxylase-containing cells constituted 13% in this region. In total, small neurons (<150 microm2) represented about 80% of the cell population in the cNTS. Predominant excitatory postsynaptic currents were observed in the adult small neurons, while inhibitory postsynaptic currents were more evident in larger neurons, irrespective of subnuclear location. This distinct differentiation of postsynaptic current patterns was not evident in neonates. GABAergic synapses were more frequently associated with dendrites of large catecholaminergic cells (73%) than with those of small calbindin-containing cells (10%) in adults. These results indicate that differential synaptic input patterns were developmentally established in distinct small and large neurons.

Authors+Show Affiliations

Department of Anatomy I, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi Minato-ku, Tokyo 105-8461, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16716422

Citation

Yoshioka, Masayuki, et al. "Pattern Differentiation of Excitatory and Inhibitory Synaptic Inputs On Distinct Neuronal Types in the Rat Caudal Nucleus of the Tractus Solitarius." Neuroscience Research, vol. 55, no. 3, 2006, pp. 300-15.
Yoshioka M, Okada T, Inoue K, et al. Pattern differentiation of excitatory and inhibitory synaptic inputs on distinct neuronal types in the rat caudal nucleus of the tractus solitarius. Neurosci Res. 2006;55(3):300-15.
Yoshioka, M., Okada, T., Inoue, K., & Kawai, Y. (2006). Pattern differentiation of excitatory and inhibitory synaptic inputs on distinct neuronal types in the rat caudal nucleus of the tractus solitarius. Neuroscience Research, 55(3), 300-15.
Yoshioka M, et al. Pattern Differentiation of Excitatory and Inhibitory Synaptic Inputs On Distinct Neuronal Types in the Rat Caudal Nucleus of the Tractus Solitarius. Neurosci Res. 2006;55(3):300-15. PubMed PMID: 16716422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pattern differentiation of excitatory and inhibitory synaptic inputs on distinct neuronal types in the rat caudal nucleus of the tractus solitarius. AU - Yoshioka,Masayuki, AU - Okada,Tomoaki, AU - Inoue,Kiyoharu, AU - Kawai,Yoshinori, Y1 - 2006/05/22/ PY - 2006/02/17/received PY - 2006/03/25/revised PY - 2006/04/03/accepted PY - 2006/5/24/pubmed PY - 2006/7/28/medline PY - 2006/5/24/entrez SP - 300 EP - 15 JF - Neuroscience research JO - Neurosci. Res. VL - 55 IS - 3 N2 - Region- and size-specific neuronal organizations of the caudal nucleus of the tractus solitarius (cNTS) were investigated, followed by analyses of excitatory and inhibitory synaptic input patterns onto specific cell types by patch clamp recordings and immunoelectron microscopy. Cell size distribution and numerical density of cNTS neurons were examined in subregions at levels of the area postrema. In the subpostremal and dorsomedial subnuclei, characterized by the presence of dense glutamatergic and sparse GABAergic somata, small calbindin neurons constituted 42% of the total cells. The medial subnucleus contained large numbers of glutamatergic, GABAergic, and catecholaminergic somata and large tyrosine hydroxylase-containing cells constituted 13% in this region. In total, small neurons (<150 microm2) represented about 80% of the cell population in the cNTS. Predominant excitatory postsynaptic currents were observed in the adult small neurons, while inhibitory postsynaptic currents were more evident in larger neurons, irrespective of subnuclear location. This distinct differentiation of postsynaptic current patterns was not evident in neonates. GABAergic synapses were more frequently associated with dendrites of large catecholaminergic cells (73%) than with those of small calbindin-containing cells (10%) in adults. These results indicate that differential synaptic input patterns were developmentally established in distinct small and large neurons. SN - 0168-0102 UR - https://www.unboundmedicine.com/medline/citation/16716422/Pattern_differentiation_of_excitatory_and_inhibitory_synaptic_inputs_on_distinct_neuronal_types_in_the_rat_caudal_nucleus_of_the_tractus_solitarius_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(06)00086-1 DB - PRIME DP - Unbound Medicine ER -