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Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder.
Psychoneuroendocrinology. 2006 Aug; 31(7):825-38.P

Abstract

BACKGROUND

Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-adrenal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD).

METHODS

We examined neuroendocrine function in female survivors of intimate partner violence (IPV) with lifetime (current or remitted) PTSD (n=29) and in women who were exposed to IPV but never developed PTSD (n=20). Salivary cortisol was collected as a marker of HPA axis function at 1, 4, 9, and 11 h after awakening. Platelet epinephrine and norepinephrine were assayed as markers of sympathetic-adrenal activation.

RESULTS

Women with lifetime PTSD had significantly higher cortisol levels across the day compared to abuse-exposed participants without PTSD, after controlling for age, depression, severity, and latency of abuse. There were no significant group differences in levels of platelet catecholamines.

CONCLUSIONS

Elevated cortisol levels may be a biomarker of IPV-related lifetime PTSD, reflecting long-lasting changes associated with trauma-exposure or possibly a reflection of risk for PTSD in women.

Authors+Show Affiliations

Department of Psychology, University of Pittsburgh Sennott Square, 3rd Floor, 210 S. Bouquet Street, Pittsburgh, PA 15260, USA. sabra.inslicht@ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16716530

Citation

Inslicht, Sabra S., et al. "Increased Cortisol in Women With Intimate Partner Violence-related Posttraumatic Stress Disorder." Psychoneuroendocrinology, vol. 31, no. 7, 2006, pp. 825-38.
Inslicht SS, Marmar CR, Neylan TC, et al. Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder. Psychoneuroendocrinology. 2006;31(7):825-38.
Inslicht, S. S., Marmar, C. R., Neylan, T. C., Metzler, T. J., Hart, S. L., Otte, C., McCaslin, S. E., Larkin, G. L., Hyman, K. B., & Baum, A. (2006). Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder. Psychoneuroendocrinology, 31(7), 825-38.
Inslicht SS, et al. Increased Cortisol in Women With Intimate Partner Violence-related Posttraumatic Stress Disorder. Psychoneuroendocrinology. 2006;31(7):825-38. PubMed PMID: 16716530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder. AU - Inslicht,Sabra S, AU - Marmar,Charles R, AU - Neylan,Thomas C, AU - Metzler,Thomas J, AU - Hart,Stacey L, AU - Otte,Christian, AU - McCaslin,Shannon E, AU - Larkin,G Luke, AU - Hyman,Kelly B, AU - Baum,Andrew, Y1 - 2006/05/23/ PY - 2005/10/18/received PY - 2006/03/13/revised PY - 2006/03/28/accepted PY - 2006/5/24/pubmed PY - 2006/9/29/medline PY - 2006/5/24/entrez SP - 825 EP - 38 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 7 N2 - BACKGROUND: Alterations of hypothalamic-pituitary-adrenal (HPA) axis function and sympathetic-adrenal activity have been proposed as key factors in biological models of posttraumatic stress disorder (PTSD). METHODS: We examined neuroendocrine function in female survivors of intimate partner violence (IPV) with lifetime (current or remitted) PTSD (n=29) and in women who were exposed to IPV but never developed PTSD (n=20). Salivary cortisol was collected as a marker of HPA axis function at 1, 4, 9, and 11 h after awakening. Platelet epinephrine and norepinephrine were assayed as markers of sympathetic-adrenal activation. RESULTS: Women with lifetime PTSD had significantly higher cortisol levels across the day compared to abuse-exposed participants without PTSD, after controlling for age, depression, severity, and latency of abuse. There were no significant group differences in levels of platelet catecholamines. CONCLUSIONS: Elevated cortisol levels may be a biomarker of IPV-related lifetime PTSD, reflecting long-lasting changes associated with trauma-exposure or possibly a reflection of risk for PTSD in women. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/16716530/Increased_cortisol_in_women_with_intimate_partner_violence_related_posttraumatic_stress_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(06)00070-9 DB - PRIME DP - Unbound Medicine ER -