Tags

Type your tag names separated by a space and hit enter

Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion.

Abstract

Failure to provide omega 3 fatty acids in the perinatal period results in alterations in nerve growth factor levels, dopamine production and permanent elevations in blood pressure. The present study investigated whether changes in brain (i.e., hypothalamus) glycerophospholipid fatty acid profiles induced by a diet rich in omega 6 fatty acids and very low in alpha-linolenic acid (ALA) during pregnancy and the perinatal period could be reversed by subsequent feeding of a diet containing ALA. Female rats (6 per group) were mated and fed either a low ALA diet or a control diet containing ALA throughout pregnancy and until weaning of the pups at 3 weeks. At weaning, the pups (20 per group) remained on the diet of their mothers until 9 weeks, when half the pups were switched onto the other diet, thus generating four groups of animals. At 33 weeks, pups were killed, the hypothalamus dissected from the male rats and analysed for glycerophospholipid fatty acids. In the animals fed the diet with very little ALA and then re-fed the control diet containing high levels of ALA for 24 weeks, the DHA levels were still significantly less than the control values in PE, PS and PI fractions, by 9%, 18% and 34%, respectively. In this group, but not in the other dietary groups, ALA was detected in all glycerophospholipid classes at 0.2-1.7% of the total fatty acids. The results suggest that omega 6-3 PUFA imbalance early in life leads to irreversible changes in hypothalamic composition. The increased ALA and reduced DHA proportions in the animals re-fed ALA in later life are consistent with a dysfunction or down-regulation of the conversion of ALA to 18:4n-3 by the delta-6 desaturase.

Authors+Show Affiliations

Department of Food Science & Nutrition, Zhejiang University, Hangzhou 310029, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16716580

Citation

Li, Duo, et al. "Omega 6 to Omega 3 Fatty Acid Imbalance Early in Life Leads to Persistent Reductions in DHA Levels in Glycerophospholipids in Rat Hypothalamus Even After Long-term Omega 3 Fatty Acid Repletion." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 74, no. 6, 2006, pp. 391-9.
Li D, Weisinger HS, Weisinger RS, et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. Prostaglandins Leukot Essent Fatty Acids. 2006;74(6):391-9.
Li, D., Weisinger, H. S., Weisinger, R. S., Mathai, M., Armitage, J. A., Vingrys, A. J., & Sinclair, A. J. (2006). Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 74(6), 391-9.
Li D, et al. Omega 6 to Omega 3 Fatty Acid Imbalance Early in Life Leads to Persistent Reductions in DHA Levels in Glycerophospholipids in Rat Hypothalamus Even After Long-term Omega 3 Fatty Acid Repletion. Prostaglandins Leukot Essent Fatty Acids. 2006;74(6):391-9. PubMed PMID: 16716580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. AU - Li,Duo, AU - Weisinger,Harrison S, AU - Weisinger,Richard S, AU - Mathai,Michael, AU - Armitage,James A, AU - Vingrys,Algis J, AU - Sinclair,Andrew J, Y1 - 2006/05/23/ PY - 2005/10/02/received PY - 2006/03/07/revised PY - 2006/03/28/accepted PY - 2006/5/24/pubmed PY - 2006/8/15/medline PY - 2006/5/24/entrez SP - 391 EP - 9 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 74 IS - 6 N2 - Failure to provide omega 3 fatty acids in the perinatal period results in alterations in nerve growth factor levels, dopamine production and permanent elevations in blood pressure. The present study investigated whether changes in brain (i.e., hypothalamus) glycerophospholipid fatty acid profiles induced by a diet rich in omega 6 fatty acids and very low in alpha-linolenic acid (ALA) during pregnancy and the perinatal period could be reversed by subsequent feeding of a diet containing ALA. Female rats (6 per group) were mated and fed either a low ALA diet or a control diet containing ALA throughout pregnancy and until weaning of the pups at 3 weeks. At weaning, the pups (20 per group) remained on the diet of their mothers until 9 weeks, when half the pups were switched onto the other diet, thus generating four groups of animals. At 33 weeks, pups were killed, the hypothalamus dissected from the male rats and analysed for glycerophospholipid fatty acids. In the animals fed the diet with very little ALA and then re-fed the control diet containing high levels of ALA for 24 weeks, the DHA levels were still significantly less than the control values in PE, PS and PI fractions, by 9%, 18% and 34%, respectively. In this group, but not in the other dietary groups, ALA was detected in all glycerophospholipid classes at 0.2-1.7% of the total fatty acids. The results suggest that omega 6-3 PUFA imbalance early in life leads to irreversible changes in hypothalamic composition. The increased ALA and reduced DHA proportions in the animals re-fed ALA in later life are consistent with a dysfunction or down-regulation of the conversion of ALA to 18:4n-3 by the delta-6 desaturase. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16716580/Omega_6_to_omega_3_fatty_acid_imbalance_early_in_life_leads_to_persistent_reductions_in_DHA_levels_in_glycerophospholipids_in_rat_hypothalamus_even_after_long_term_omega_3_fatty_acid_repletion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(06)00050-0 DB - PRIME DP - Unbound Medicine ER -