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Performance-based physical function and future dementia in older people.
Arch Intern Med 2006; 166(10):1115-20AI

Abstract

BACKGROUND

The association of physical function with progression to dementia has not been well investigated. We aimed to determine whether physical function is associated with incident dementia and Alzheimer disease (AD).

METHODS

We performed a prospective cohort study of 2288 persons 65 years and older without dementia. Patients were enrolled from 1994 to 1996 and followed up through October 2003. Main outcome measures included incident dementia and AD.

RESULTS

During follow-up 319 participants developed dementia (221 had AD). The age-specific incidence rate of dementia was 53.1 per 1000 person-years for participants who scored lower on a performance-based physical function test at baseline (< or = 10 points) compared with 17.4 per 1000 person-years for those who scored higher (> 10 points). A 1-point lower performance-based physical function score was associated with an increased risk of dementia (hazard ratio, 1.08; 95% confidence interval, 1.03-1.13; P < .001), an increased risk of AD (hazard ratio, 1.06; 95% confidence interval, 1.01-1.12; P = .01), and an increased rate of decline in the Cognitive Ability Screening Instrument scores (0.11 point per year; 95% confidence interval, 0.08-0.14; P < .001) after adjusting for age, sex, years of education, baseline cognitive function, APOE epsilon4 allele, family history of AD, depression, coronary heart disease, and cerebrovascular disease.

CONCLUSIONS

Lower levels of physical performance were associated with an increased risk of dementia and AD. The study suggests that poor physical function may precede the onset of dementia and AD and higher levels of physical function may be associated with a delayed onset.

Authors+Show Affiliations

Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16717174

Citation

Wang, Li, et al. "Performance-based Physical Function and Future Dementia in Older People." Archives of Internal Medicine, vol. 166, no. 10, 2006, pp. 1115-20.
Wang L, Larson EB, Bowen JD, et al. Performance-based physical function and future dementia in older people. Arch Intern Med. 2006;166(10):1115-20.
Wang, L., Larson, E. B., Bowen, J. D., & van Belle, G. (2006). Performance-based physical function and future dementia in older people. Archives of Internal Medicine, 166(10), pp. 1115-20.
Wang L, et al. Performance-based Physical Function and Future Dementia in Older People. Arch Intern Med. 2006 May 22;166(10):1115-20. PubMed PMID: 16717174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Performance-based physical function and future dementia in older people. AU - Wang,Li, AU - Larson,Eric B, AU - Bowen,James D, AU - van Belle,Gerald, PY - 2006/5/24/pubmed PY - 2006/6/16/medline PY - 2006/5/24/entrez SP - 1115 EP - 20 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 166 IS - 10 N2 - BACKGROUND: The association of physical function with progression to dementia has not been well investigated. We aimed to determine whether physical function is associated with incident dementia and Alzheimer disease (AD). METHODS: We performed a prospective cohort study of 2288 persons 65 years and older without dementia. Patients were enrolled from 1994 to 1996 and followed up through October 2003. Main outcome measures included incident dementia and AD. RESULTS: During follow-up 319 participants developed dementia (221 had AD). The age-specific incidence rate of dementia was 53.1 per 1000 person-years for participants who scored lower on a performance-based physical function test at baseline (< or = 10 points) compared with 17.4 per 1000 person-years for those who scored higher (> 10 points). A 1-point lower performance-based physical function score was associated with an increased risk of dementia (hazard ratio, 1.08; 95% confidence interval, 1.03-1.13; P < .001), an increased risk of AD (hazard ratio, 1.06; 95% confidence interval, 1.01-1.12; P = .01), and an increased rate of decline in the Cognitive Ability Screening Instrument scores (0.11 point per year; 95% confidence interval, 0.08-0.14; P < .001) after adjusting for age, sex, years of education, baseline cognitive function, APOE epsilon4 allele, family history of AD, depression, coronary heart disease, and cerebrovascular disease. CONCLUSIONS: Lower levels of physical performance were associated with an increased risk of dementia and AD. The study suggests that poor physical function may precede the onset of dementia and AD and higher levels of physical function may be associated with a delayed onset. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/16717174/Performance_based_physical_function_and_future_dementia_in_older_people_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.166.10.1115 DB - PRIME DP - Unbound Medicine ER -