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Physiological basis for effect of physical conditioning on chronic ethanol-induced hypertension in a rat model.
Mol Cell Biochem. 2006 Sep; 289(1-2):175-83.MC

Abstract

The study aim was to investigate the interaction of physical conditioning and chronic ethanol ingestion on blood pressure (BP), heart rate (HR), nitric oxide (NO) and oxidants/antioxidants balance in the plasma of rats. Male Fisher rats were divided into four groups of seven animals each and treated as follows: (1) Control (5% sucrose, orally) daily for 12 weeks; (2) ethanol (4 g kg(-1), orally) daily for 12 weeks; (3) exercise training on treadmill plus sucrose daily for 12 weeks and (4) exercise training on treadmill followed by ethanol (4 g kg(-1), orally) daily for 12 weeks. The body weight, BP and HR were recorded every week. The animals were sacrificed under ether anesthesia after 12 weeks, blood collected in heparinzed vials, plasma isolated and analyzed. The results show that exercise training significantly lowered the weight gain 6-12 weeks in ethanol treated rats compared to ethanol alone or control rats. The mean arterial BP was significantly elevated 6-12 weeks after ethanol ingestion without significant alterations in HR. Exercise training lowered the BP close to the normal control values in ethanol fed rats. Ethanol significantly decreased the plasma NO levels, reduced to oxidized glutathione ratio (GSH/GSSG) and antioxidant enzymes-superoxide dismutase (CuZn-SOD, and Mn-SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities while plasma NADPH oxidase activity and malondialdehyde (MDA) levels were significantly elevated compared to control. Exercise training significantly restored the depletion of plasma NO levels, GSH/GSSG ratio, and antioxidant enzyme activities and normalized the MDA levels and NADPH oxidase activity in the plasma of ethanol treated rats. The study concluded that physical conditioning attenuates the chronic ethanol-induced hypertension by augmenting the NO bioavailability and reducing the oxidative stress response in the plasma of rats.

Authors+Show Affiliations

Department of Physiology, Pharmacology and Toxicology, Ponce School of Medicine, P.O. Box 7004, Ponce, PR 00732-7004. khusain@psm.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16718371

Citation

Husain, Kazim, et al. "Physiological Basis for Effect of Physical Conditioning On Chronic Ethanol-induced Hypertension in a Rat Model." Molecular and Cellular Biochemistry, vol. 289, no. 1-2, 2006, pp. 175-83.
Husain K, Mejia J, Lalla J. Physiological basis for effect of physical conditioning on chronic ethanol-induced hypertension in a rat model. Mol Cell Biochem. 2006;289(1-2):175-83.
Husain, K., Mejia, J., & Lalla, J. (2006). Physiological basis for effect of physical conditioning on chronic ethanol-induced hypertension in a rat model. Molecular and Cellular Biochemistry, 289(1-2), 175-83.
Husain K, Mejia J, Lalla J. Physiological Basis for Effect of Physical Conditioning On Chronic Ethanol-induced Hypertension in a Rat Model. Mol Cell Biochem. 2006;289(1-2):175-83. PubMed PMID: 16718371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological basis for effect of physical conditioning on chronic ethanol-induced hypertension in a rat model. AU - Husain,Kazim, AU - Mejia,Jose, AU - Lalla,Jainarine, Y1 - 2006/05/23/ PY - 2006/01/04/received PY - 2006/02/16/accepted PY - 2006/5/24/pubmed PY - 2006/12/9/medline PY - 2006/5/24/entrez SP - 175 EP - 83 JF - Molecular and cellular biochemistry JO - Mol Cell Biochem VL - 289 IS - 1-2 N2 - The study aim was to investigate the interaction of physical conditioning and chronic ethanol ingestion on blood pressure (BP), heart rate (HR), nitric oxide (NO) and oxidants/antioxidants balance in the plasma of rats. Male Fisher rats were divided into four groups of seven animals each and treated as follows: (1) Control (5% sucrose, orally) daily for 12 weeks; (2) ethanol (4 g kg(-1), orally) daily for 12 weeks; (3) exercise training on treadmill plus sucrose daily for 12 weeks and (4) exercise training on treadmill followed by ethanol (4 g kg(-1), orally) daily for 12 weeks. The body weight, BP and HR were recorded every week. The animals were sacrificed under ether anesthesia after 12 weeks, blood collected in heparinzed vials, plasma isolated and analyzed. The results show that exercise training significantly lowered the weight gain 6-12 weeks in ethanol treated rats compared to ethanol alone or control rats. The mean arterial BP was significantly elevated 6-12 weeks after ethanol ingestion without significant alterations in HR. Exercise training lowered the BP close to the normal control values in ethanol fed rats. Ethanol significantly decreased the plasma NO levels, reduced to oxidized glutathione ratio (GSH/GSSG) and antioxidant enzymes-superoxide dismutase (CuZn-SOD, and Mn-SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities while plasma NADPH oxidase activity and malondialdehyde (MDA) levels were significantly elevated compared to control. Exercise training significantly restored the depletion of plasma NO levels, GSH/GSSG ratio, and antioxidant enzyme activities and normalized the MDA levels and NADPH oxidase activity in the plasma of ethanol treated rats. The study concluded that physical conditioning attenuates the chronic ethanol-induced hypertension by augmenting the NO bioavailability and reducing the oxidative stress response in the plasma of rats. SN - 0300-8177 UR - https://www.unboundmedicine.com/medline/citation/16718371/Physiological_basis_for_effect_of_physical_conditioning_on_chronic_ethanol_induced_hypertension_in_a_rat_model_ L2 - https://doi.org/10.1007/s11010-006-9161-3 DB - PRIME DP - Unbound Medicine ER -