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Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems.
J Agric Food Chem. 2006 May 31; 54(11):3779-85.JA

Abstract

Antioxidant activities of lipophilic hydroxytyrosyl acetate, palmitate, oleate, and linoleate were compared with those of hydroxytyrosol, alpha-tocopherol, and butylhydroxytoluene (BHT) in both glyceridic matrix and biological systems. Aliquots of a glyceridic matrix spiked with various concentrations of antioxidant were subjected to accelerated oxidation in a Rancimat apparatus operated at 90 degrees C. The relationships between induction time (IT) and antioxidant concentration (mmol/kg) presented by hydroxytyrosol and hydroxytyrosyl acetate, palmitate, oleate, and linoleate were similar. Hydroxytyrosol and its esters showed greater antioxidant activity than alpha-tocopherol or BHT. We also evaluated the capacity of hydroxytyrosyl esters to protect proteins and lipids against oxidation caused by peroxyl radicals, using a brain homogenate as an ex vivo model. All tested compounds showed a protective effect in these systems, which was greater in preventing the generation of carbonyl groups in protein than of malondialdehyde in lipid. Inclusion of a lipophilic chain in the hydroxytyrosol molecule enhanced its antioxidant capacities in this biological model.

Authors+Show Affiliations

Departamento de Química Organica y Farmacéutica and Departamento de Bioquímica, Facultad de Farmacia, Universidad de Sevilla, C/Prof. García Gonzalez 2, 41012 Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16719496

Citation

Trujillo, Mariana, et al. "Lipophilic Hydroxytyrosyl Esters. Antioxidant Activity in Lipid Matrices and Biological Systems." Journal of Agricultural and Food Chemistry, vol. 54, no. 11, 2006, pp. 3779-85.
Trujillo M, Mateos R, Collantes de Teran L, et al. Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems. J Agric Food Chem. 2006;54(11):3779-85.
Trujillo, M., Mateos, R., Collantes de Teran, L., Espartero, J. L., Cert, R., Jover, M., Alcudia, F., Bautista, J., Cert, A., & Parrado, J. (2006). Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems. Journal of Agricultural and Food Chemistry, 54(11), 3779-85.
Trujillo M, et al. Lipophilic Hydroxytyrosyl Esters. Antioxidant Activity in Lipid Matrices and Biological Systems. J Agric Food Chem. 2006 May 31;54(11):3779-85. PubMed PMID: 16719496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems. AU - Trujillo,Mariana, AU - Mateos,Raquel, AU - Collantes de Teran,Laura, AU - Espartero,José L, AU - Cert,Rosa, AU - Jover,Maria, AU - Alcudia,Felipe, AU - Bautista,Juan, AU - Cert,Arturo, AU - Parrado,Juan, PY - 2006/5/25/pubmed PY - 2006/6/30/medline PY - 2006/5/25/entrez SP - 3779 EP - 85 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 11 N2 - Antioxidant activities of lipophilic hydroxytyrosyl acetate, palmitate, oleate, and linoleate were compared with those of hydroxytyrosol, alpha-tocopherol, and butylhydroxytoluene (BHT) in both glyceridic matrix and biological systems. Aliquots of a glyceridic matrix spiked with various concentrations of antioxidant were subjected to accelerated oxidation in a Rancimat apparatus operated at 90 degrees C. The relationships between induction time (IT) and antioxidant concentration (mmol/kg) presented by hydroxytyrosol and hydroxytyrosyl acetate, palmitate, oleate, and linoleate were similar. Hydroxytyrosol and its esters showed greater antioxidant activity than alpha-tocopherol or BHT. We also evaluated the capacity of hydroxytyrosyl esters to protect proteins and lipids against oxidation caused by peroxyl radicals, using a brain homogenate as an ex vivo model. All tested compounds showed a protective effect in these systems, which was greater in preventing the generation of carbonyl groups in protein than of malondialdehyde in lipid. Inclusion of a lipophilic chain in the hydroxytyrosol molecule enhanced its antioxidant capacities in this biological model. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16719496/Lipophilic_hydroxytyrosyl_esters__Antioxidant_activity_in_lipid_matrices_and_biological_systems_ L2 - https://doi.org/10.1021/jf060520z DB - PRIME DP - Unbound Medicine ER -