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Treatment of localized vitiligo with targeted broadband UVB phototherapy: a pilot study.
Photodermatol Photoimmunol Photomed. 2006 Jun; 22(3):133-6.PP

Abstract

BACKGROUND

Narrowband ultraviolet B (UVB) phototherapy and 308 nm excimer laser have produced encouraging therapeutic results for vitiligo. Repigmentation of various degrees was obtained in different studies.

MATERIALS AND METHODS

Twenty-nine vitiliginous lesions from six patients were treated with targeted, broadband UV-B phototherapy. UV fluences were started at 50% of the minimal erythema dose, then increased gradually. Treatments were carried out twice weekly for 12 weeks.

RESULTS

Some degree of repigmentation occurred in all subjects. Responses varied among the different anatomic locations, with acral lesions achieving the least improvement. Onset of repigmentation was as early as 3 weeks of treatment in some subjects. Treatments were well tolerated, with only minimal erythema and hyperpigmentation.

LIMITATIONS

This study was carried out in a smaller number of patients with skin types III and IV. The irradiation device was a broadband UVB device, and thus the results may not be similar to those obtained from a more monochromatic system such as an excimer laser.

CONCLUSIONS

Targeted broadband UVB is an efficacious and safe modality for the treatment of localized vitiligo.

Authors+Show Affiliations

Asawanonda P
Division of Dermatology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand. pravit@adsl.loxinfo.com
Charoenlap M
No affiliation info available
Korkij W
No affiliation info available

MeSH

AdultErythemaFemaleHumansMaleMiddle AgedPilot ProjectsSkin PigmentationUltraviolet RaysUltraviolet TherapyVitiligo

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16719866

Citation

Asawanonda, Pravit, et al. "Treatment of Localized Vitiligo With Targeted Broadband UVB Phototherapy: a Pilot Study." Photodermatology, Photoimmunology & Photomedicine, vol. 22, no. 3, 2006, pp. 133-6.
Asawanonda P, Charoenlap M, Korkij W. Treatment of localized vitiligo with targeted broadband UVB phototherapy: a pilot study. Photodermatol Photoimmunol Photomed. 2006;22(3):133-6.
Asawanonda, P., Charoenlap, M., & Korkij, W. (2006). Treatment of localized vitiligo with targeted broadband UVB phototherapy: a pilot study. Photodermatology, Photoimmunology & Photomedicine, 22(3), 133-6.
Asawanonda P, Charoenlap M, Korkij W. Treatment of Localized Vitiligo With Targeted Broadband UVB Phototherapy: a Pilot Study. Photodermatol Photoimmunol Photomed. 2006;22(3):133-6. PubMed PMID: 16719866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of localized vitiligo with targeted broadband UVB phototherapy: a pilot study. AU - Asawanonda,Pravit, AU - Charoenlap,Marisa, AU - Korkij,Wiwat, PY - 2006/5/25/pubmed PY - 2006/11/3/medline PY - 2006/5/25/entrez SP - 133 EP - 6 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 22 IS - 3 N2 - BACKGROUND: Narrowband ultraviolet B (UVB) phototherapy and 308 nm excimer laser have produced encouraging therapeutic results for vitiligo. Repigmentation of various degrees was obtained in different studies. MATERIALS AND METHODS: Twenty-nine vitiliginous lesions from six patients were treated with targeted, broadband UV-B phototherapy. UV fluences were started at 50% of the minimal erythema dose, then increased gradually. Treatments were carried out twice weekly for 12 weeks. RESULTS: Some degree of repigmentation occurred in all subjects. Responses varied among the different anatomic locations, with acral lesions achieving the least improvement. Onset of repigmentation was as early as 3 weeks of treatment in some subjects. Treatments were well tolerated, with only minimal erythema and hyperpigmentation. LIMITATIONS: This study was carried out in a smaller number of patients with skin types III and IV. The irradiation device was a broadband UVB device, and thus the results may not be similar to those obtained from a more monochromatic system such as an excimer laser. CONCLUSIONS: Targeted broadband UVB is an efficacious and safe modality for the treatment of localized vitiligo. SN - 0905-4383 UR - https://www.unboundmedicine.com/medline/citation/16719866/Treatment_of_localized_vitiligo_with_targeted_broadband_UVB_phototherapy:_a_pilot_study_ DB - PRIME DP - Unbound Medicine ER -