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Pre-natal and post-natal exposure to respiratory infection and atopic diseases development: a historical cohort study.
Respir Res. 2006 May 23; 7:81.RR

Abstract

BACKGROUND

According to the hygiene hypothesis, infections in early life protect from allergic diseases. However, in earlier studies surrogate measures of infection rather than clinical infections were associated with decreased frequencies of atopic diseases. Exposure to infection indicating sub-clinical infection rather than clinical infection might protect from atopic diseases.

OBJECTIVE

to investigate whether exposure to acute respiratory infections within pregnancy and the first year of life is associated with atopic conditions at age 5-14 years and to explore when within pregnancy and the first year of life this exposure is most likely to be protective.

METHODS

Historical cohort study: Population level data on acute respiratory infections from the routine reporting system of the former German Democratic Republic were linked with individual data from consecutive surveys on atopic diseases in the same region (n = 4672). Statistical analyses included multivariate logistic regression analysis and polynomial distributed lag models.

RESULTS

High exposure to acute respiratory infection between pregnancy and age one year was associated with overall reduced odds of asthma, eczema, hay fever, atopic sensitization and total IgE. Exposure in the first 9 months of life showed the most pronounced effect. Adjusted odds ratio's for asthma, hay fever, inhalant sensitization and total IgE were statistical significantly reduced up to around half.

CONCLUSION

Exposure to respiratory infection (most likely indicating sub-clinical infection) within pregnancy and the first year of life may be protective in atopic diseases development. The post-natal period thereby seems to be particularly important.

Authors+Show Affiliations

GSF- Institut für Epidemiologie, Neuherberg, Germany. anne.zutavern@gsf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16719901

Citation

Zutavern, Anne, et al. "Pre-natal and Post-natal Exposure to Respiratory Infection and Atopic Diseases Development: a Historical Cohort Study." Respiratory Research, vol. 7, 2006, p. 81.
Zutavern A, von Klot S, Gehring U, et al. Pre-natal and post-natal exposure to respiratory infection and atopic diseases development: a historical cohort study. Respir Res. 2006;7:81.
Zutavern, A., von Klot, S., Gehring, U., Krauss-Etschmann, S., & Heinrich, J. (2006). Pre-natal and post-natal exposure to respiratory infection and atopic diseases development: a historical cohort study. Respiratory Research, 7, 81.
Zutavern A, et al. Pre-natal and Post-natal Exposure to Respiratory Infection and Atopic Diseases Development: a Historical Cohort Study. Respir Res. 2006 May 23;7:81. PubMed PMID: 16719901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-natal and post-natal exposure to respiratory infection and atopic diseases development: a historical cohort study. AU - Zutavern,Anne, AU - von Klot,Stephanie, AU - Gehring,Ulrike, AU - Krauss-Etschmann,Susanne, AU - Heinrich,Joachim, Y1 - 2006/05/23/ PY - 2006/01/10/received PY - 2006/05/23/accepted PY - 2006/5/25/pubmed PY - 2006/8/26/medline PY - 2006/5/25/entrez SP - 81 EP - 81 JF - Respiratory research JO - Respir Res VL - 7 N2 - BACKGROUND: According to the hygiene hypothesis, infections in early life protect from allergic diseases. However, in earlier studies surrogate measures of infection rather than clinical infections were associated with decreased frequencies of atopic diseases. Exposure to infection indicating sub-clinical infection rather than clinical infection might protect from atopic diseases. OBJECTIVE: to investigate whether exposure to acute respiratory infections within pregnancy and the first year of life is associated with atopic conditions at age 5-14 years and to explore when within pregnancy and the first year of life this exposure is most likely to be protective. METHODS: Historical cohort study: Population level data on acute respiratory infections from the routine reporting system of the former German Democratic Republic were linked with individual data from consecutive surveys on atopic diseases in the same region (n = 4672). Statistical analyses included multivariate logistic regression analysis and polynomial distributed lag models. RESULTS: High exposure to acute respiratory infection between pregnancy and age one year was associated with overall reduced odds of asthma, eczema, hay fever, atopic sensitization and total IgE. Exposure in the first 9 months of life showed the most pronounced effect. Adjusted odds ratio's for asthma, hay fever, inhalant sensitization and total IgE were statistical significantly reduced up to around half. CONCLUSION: Exposure to respiratory infection (most likely indicating sub-clinical infection) within pregnancy and the first year of life may be protective in atopic diseases development. The post-natal period thereby seems to be particularly important. SN - 1465-993X UR - https://www.unboundmedicine.com/medline/citation/16719901/Pre_natal_and_post_natal_exposure_to_respiratory_infection_and_atopic_diseases_development:_a_historical_cohort_study_ L2 - https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-7-81 DB - PRIME DP - Unbound Medicine ER -