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Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL.
Ann Med 2006; 38(3):229-38AM

Abstract

BACKGROUND

Inhibition of cytokine-induced expression of adhesion molecules is one of the atheroprotective mechanisms of high-density lipoprotein (HDL).

AIM

We investigated whether increased endothelial activation and low-grade inflammation are present in Finnish subjects with familial low HDL, and which factors contribute to the inflammatory parameters.

METHOD

High-sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), and sE-selectin were measured in 91 subjects with low HDL-cholesterol from 41 low-HDL families and in 112 normolipidemic controls with comparable age- and gender distribution. Presence of the features of the metabolic syndrome (MetS) was recorded.

RESULTS

sVCAM-1, sICAM-1, sE-selectin, and hsCRP were significantly higher in low-HDL subjects than in the controls (sVCAM-1: 560+/-147 ng/mL versus 496+/-95 ng/mL, P = 0.001; sICAM-1: 247+/-60 ng/mL versus 215+/-47 ng/mL, P<0.001; sE-selectin: 52+/-20 ng/mL versus 44+/-16 ng/mL, P = 0.022; and hsCRP: 1.73+/-2.05 mg/L versus 0.85+/-1.10 mg/L, P<0.001). Low-HDL subjects had increased body mass index (BMI) and waist, and elevated insulin and triglyceride levels. Adhesion molecules and hsCRP increased according to the number of the features of the MetS.

CONCLUSIONS

The presence of the MetS in subjects with familial low HDL-cholesterol aggravates the low-grade inflammation and endothelial activation, and ultimately may add to the higher susceptibility for atherosclerotic disease in these individuals.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16720437

Citation

Soro-Paavonen, Aino, et al. "Metabolic Syndrome Aggravates the Increased Endothelial Activation and Low-grade Inflammation in Subjects With Familial Low HDL." Annals of Medicine, vol. 38, no. 3, 2006, pp. 229-38.
Soro-Paavonen A, Westerbacka J, Ehnholm C, et al. Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL. Ann Med. 2006;38(3):229-38.
Soro-Paavonen, A., Westerbacka, J., Ehnholm, C., & Taskinen, M. R. (2006). Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL. Annals of Medicine, 38(3), pp. 229-38.
Soro-Paavonen A, et al. Metabolic Syndrome Aggravates the Increased Endothelial Activation and Low-grade Inflammation in Subjects With Familial Low HDL. Ann Med. 2006;38(3):229-38. PubMed PMID: 16720437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL. AU - Soro-Paavonen,Aino, AU - Westerbacka,Jukka, AU - Ehnholm,Christian, AU - Taskinen,Marja-Riitta, PY - 2006/5/25/pubmed PY - 2006/6/16/medline PY - 2006/5/25/entrez SP - 229 EP - 38 JF - Annals of medicine JO - Ann. Med. VL - 38 IS - 3 N2 - BACKGROUND: Inhibition of cytokine-induced expression of adhesion molecules is one of the atheroprotective mechanisms of high-density lipoprotein (HDL). AIM: We investigated whether increased endothelial activation and low-grade inflammation are present in Finnish subjects with familial low HDL, and which factors contribute to the inflammatory parameters. METHOD: High-sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), and sE-selectin were measured in 91 subjects with low HDL-cholesterol from 41 low-HDL families and in 112 normolipidemic controls with comparable age- and gender distribution. Presence of the features of the metabolic syndrome (MetS) was recorded. RESULTS: sVCAM-1, sICAM-1, sE-selectin, and hsCRP were significantly higher in low-HDL subjects than in the controls (sVCAM-1: 560+/-147 ng/mL versus 496+/-95 ng/mL, P = 0.001; sICAM-1: 247+/-60 ng/mL versus 215+/-47 ng/mL, P<0.001; sE-selectin: 52+/-20 ng/mL versus 44+/-16 ng/mL, P = 0.022; and hsCRP: 1.73+/-2.05 mg/L versus 0.85+/-1.10 mg/L, P<0.001). Low-HDL subjects had increased body mass index (BMI) and waist, and elevated insulin and triglyceride levels. Adhesion molecules and hsCRP increased according to the number of the features of the MetS. CONCLUSIONS: The presence of the MetS in subjects with familial low HDL-cholesterol aggravates the low-grade inflammation and endothelial activation, and ultimately may add to the higher susceptibility for atherosclerotic disease in these individuals. SN - 0785-3890 UR - https://www.unboundmedicine.com/medline/citation/16720437/Metabolic_syndrome_aggravates_the_increased_endothelial_activation_and_low_grade_inflammation_in_subjects_with_familial_low_HDL_ L2 - http://www.tandfonline.com/doi/full/10.1080/07853890500526352 DB - PRIME DP - Unbound Medicine ER -