Tags

Type your tag names separated by a space and hit enter

Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia.
Mov Disord. 2006 Sep; 21(9):1343-9.MD

Abstract

The aim of this study was to establish the rate of progression from mild cognitive impairment (MCI) to dementia in patients with Parkinson's disease (PD). PD patients without dementia were recruited in 1997 from an ongoing prospective epidemiological study. The assessment included neurological and psychiatric examinations, a clinical interview based on the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R) criteria for dementia, and a battery of neuropsychological tests. PD was diagnosed according to established criteria, dementia was diagnosed according to the DSM-III-R criteria, and subtypes of MCI were classified according to modified Petersen's criteria. Seventy-two nondemented PD patients were included. A total of 34 were cognitively intact, whereas 38 were diagnosed with MCI (amnestic, n = 6; single nonmemory domain, n = 17; multiple domains slightly impaired, n = 15). Fifty-nine patients (82%) completed follow-up examination 4 years later, and 18 (62%) of the patients with MCI and 6 (20%) of the cognitively intact PD patients were demented (P = 0.001). Single domain nonmemory MCI and multiple domains slightly impaired MCI were associated with later development of dementia (P = 0.003; P = 0.04), whereas amnestic MCI subtype was not (P = 0.76). We conclude that patients with PD and MCI had a higher risk of developing dementia than cognitively intact PD patients, suggesting that MCI in PD is an early manifestation of dementia. However, these findings should be interpreted with caution due to the relatively small number of subjects included in this study.

Authors+Show Affiliations

Stavanger University Hospital, Section of Geriatric Psychiatry, Stavanger, Norway.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16721732

Citation

Janvin, Carmen Cristea, et al. "Subtypes of Mild Cognitive Impairment in Parkinson's Disease: Progression to Dementia." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 9, 2006, pp. 1343-9.
Janvin CC, Larsen JP, Aarsland D, et al. Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia. Mov Disord. 2006;21(9):1343-9.
Janvin, C. C., Larsen, J. P., Aarsland, D., & Hugdahl, K. (2006). Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia. Movement Disorders : Official Journal of the Movement Disorder Society, 21(9), 1343-9.
Janvin CC, et al. Subtypes of Mild Cognitive Impairment in Parkinson's Disease: Progression to Dementia. Mov Disord. 2006;21(9):1343-9. PubMed PMID: 16721732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia. AU - Janvin,Carmen Cristea, AU - Larsen,Jan Petter, AU - Aarsland,Dag, AU - Hugdahl,Kenneth, PY - 2006/5/25/pubmed PY - 2007/2/3/medline PY - 2006/5/25/entrez SP - 1343 EP - 9 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 21 IS - 9 N2 - The aim of this study was to establish the rate of progression from mild cognitive impairment (MCI) to dementia in patients with Parkinson's disease (PD). PD patients without dementia were recruited in 1997 from an ongoing prospective epidemiological study. The assessment included neurological and psychiatric examinations, a clinical interview based on the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R) criteria for dementia, and a battery of neuropsychological tests. PD was diagnosed according to established criteria, dementia was diagnosed according to the DSM-III-R criteria, and subtypes of MCI were classified according to modified Petersen's criteria. Seventy-two nondemented PD patients were included. A total of 34 were cognitively intact, whereas 38 were diagnosed with MCI (amnestic, n = 6; single nonmemory domain, n = 17; multiple domains slightly impaired, n = 15). Fifty-nine patients (82%) completed follow-up examination 4 years later, and 18 (62%) of the patients with MCI and 6 (20%) of the cognitively intact PD patients were demented (P = 0.001). Single domain nonmemory MCI and multiple domains slightly impaired MCI were associated with later development of dementia (P = 0.003; P = 0.04), whereas amnestic MCI subtype was not (P = 0.76). We conclude that patients with PD and MCI had a higher risk of developing dementia than cognitively intact PD patients, suggesting that MCI in PD is an early manifestation of dementia. However, these findings should be interpreted with caution due to the relatively small number of subjects included in this study. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16721732/Subtypes_of_mild_cognitive_impairment_in_Parkinson's_disease:_progression_to_dementia_ L2 - https://doi.org/10.1002/mds.20974 DB - PRIME DP - Unbound Medicine ER -