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Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant.
J Med Virol. 2006 Jul; 78(7):954-63.JM

Abstract

A safe and effective adjuvant is necessary to enhance mucosal immune responses for the development of an inactivated intranasal influenza vaccine. The present study demonstrated the effectiveness of surf clam microparticles (SMP) derived from natural surf clams as an adjuvant for an intranasal influenza vaccine. The adjuvant effect of SMP was examined when co-administered intranasally with inactivated A/PR8 (H1N1) influenza virus hemagglutinin vaccine in BALB/c mice. Administration of the vaccine with SMP induced a high anti-PR8 haemagglutinin (HA)-specific immunoglobulin A (IgA) response in the nasal wash and immunoglobulin G (IgG) response in the serum, resulting in protection against both nasal-restricted infection and lethal lung infection by A/PR8 virus. In addition, administration of SMP with A/Yamagata (H1N1), A/Beijing (H1N1), or A/Guizhou (H3N2) vaccine conferred complete protection against A/PR8 virus challenge in the nasal infection model, suggesting that SMP adjuvanted vaccine can confer cross-protection against variant influenza viruses. The use of SMP is suggested as a new safe and effective mucosal adjuvant for nasal vaccination against influenza virus infection.

Authors+Show Affiliations

Ichinohe T
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Watanabe I
No affiliation info available
Tao E
No affiliation info available
Ito S
No affiliation info available
Kawaguchi A
No affiliation info available
Tamura S
No affiliation info available
Takahashi H
No affiliation info available
Sawa H
No affiliation info available
Moriyama M
No affiliation info available
Chiba J
No affiliation info available
Komase K
No affiliation info available
Suzuki Y
No affiliation info available
Kurata T
No affiliation info available
Sata T
No affiliation info available
Hasegawa H
No affiliation info available

MeSH

Adjuvants, ImmunologicAdministration, IntranasalAnimalsBivalviaBrainFemaleHemagglutinin Glycoproteins, Influenza VirusHumansImmunity, MucosalInfluenza A virusInfluenza VaccinesInfluenza, HumanInjectionsInjections, IntraperitonealMiceMice, Inbred BALB COrthomyxoviridae InfectionsSafetyStomachT-LymphocytesVaccines, Inactivated

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16721854

Citation

Ichinohe, Takeshi, et al. "Protection Against Influenza Virus Infection By Intranasal Vaccine With Surf Clam Microparticles (SMP) as an Adjuvant." Journal of Medical Virology, vol. 78, no. 7, 2006, pp. 954-63.
Ichinohe T, Watanabe I, Tao E, et al. Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant. J Med Virol. 2006;78(7):954-63.
Ichinohe, T., Watanabe, I., Tao, E., Ito, S., Kawaguchi, A., Tamura, S., Takahashi, H., Sawa, H., Moriyama, M., Chiba, J., Komase, K., Suzuki, Y., Kurata, T., Sata, T., & Hasegawa, H. (2006). Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant. Journal of Medical Virology, 78(7), 954-63.
Ichinohe T, et al. Protection Against Influenza Virus Infection By Intranasal Vaccine With Surf Clam Microparticles (SMP) as an Adjuvant. J Med Virol. 2006;78(7):954-63. PubMed PMID: 16721854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant. AU - Ichinohe,Takeshi, AU - Watanabe,Izumi, AU - Tao,Eriko, AU - Ito,Satoshi, AU - Kawaguchi,Akira, AU - Tamura,Shin-ichi, AU - Takahashi,Hidehiro, AU - Sawa,Hirofumi, AU - Moriyama,Masami, AU - Chiba,Joe, AU - Komase,Katsuhiro, AU - Suzuki,Yujiro, AU - Kurata,Takeshi, AU - Sata,Tetsutaro, AU - Hasegawa,Hideki, PY - 2006/5/25/pubmed PY - 2006/8/12/medline PY - 2006/5/25/entrez SP - 954 EP - 63 JF - Journal of medical virology JO - J Med Virol VL - 78 IS - 7 N2 - A safe and effective adjuvant is necessary to enhance mucosal immune responses for the development of an inactivated intranasal influenza vaccine. The present study demonstrated the effectiveness of surf clam microparticles (SMP) derived from natural surf clams as an adjuvant for an intranasal influenza vaccine. The adjuvant effect of SMP was examined when co-administered intranasally with inactivated A/PR8 (H1N1) influenza virus hemagglutinin vaccine in BALB/c mice. Administration of the vaccine with SMP induced a high anti-PR8 haemagglutinin (HA)-specific immunoglobulin A (IgA) response in the nasal wash and immunoglobulin G (IgG) response in the serum, resulting in protection against both nasal-restricted infection and lethal lung infection by A/PR8 virus. In addition, administration of SMP with A/Yamagata (H1N1), A/Beijing (H1N1), or A/Guizhou (H3N2) vaccine conferred complete protection against A/PR8 virus challenge in the nasal infection model, suggesting that SMP adjuvanted vaccine can confer cross-protection against variant influenza viruses. The use of SMP is suggested as a new safe and effective mucosal adjuvant for nasal vaccination against influenza virus infection. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/16721854/Protection_against_influenza_virus_infection_by_intranasal_vaccine_with_surf_clam_microparticles__SMP__as_an_adjuvant_ DB - PRIME DP - Unbound Medicine ER -