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[Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl].
Zhong Yao Cai. 2006 Jan; 29(1):16-9.ZY

Abstract

OBJECTIVE

To study the antihyperlipidemia effective constituent of Polygala fallax Hemsl.

METHOD

Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant and the structures were elucidated by IR, NMR and MS spectroscopy.

RESULT

Four triterpenoid saponins were isolated and determined as 3-O-beta-D-glucopyranosyl-(1--> 2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -beta-D-fucopyranosyl ester (I), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(3-O-acetyl)-beta-D-fucopyranosyl ester (II), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(4-O-acetyl) -beta-D-fucopyranosyl ester (II) and 3-O-beta-D-glucopyranosyl-(1--2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) - (3,4-diacetyl) -beta-D-fucopyranosyl ester (IV).

CONCLUSIONS

The effective constituents of Polygala fallax Hemsl. reduced blood lipid especially plasma TG markedly. The authors have studied the chemical constituents of effective constituent systematically for the first time.

Authors+Show Affiliations

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16722311

Citation

Xu, Kang-Ping, et al. "[Study On the Antihyperlipidemia Effective Constituent of Polygala Fallax Hemsl]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 29, no. 1, 2006, pp. 16-9.
Xu KP, Huang W, Tan JB, et al. [Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl]. Zhong Yao Cai. 2006;29(1):16-9.
Xu, K. P., Huang, W., Tan, J. B., Zhou, Y. J., Li, F. S., Huang, Z. H., Liu, B. C., & Tan, G. S. (2006). [Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 29(1), 16-9.
Xu KP, et al. [Study On the Antihyperlipidemia Effective Constituent of Polygala Fallax Hemsl]. Zhong Yao Cai. 2006;29(1):16-9. PubMed PMID: 16722311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl]. AU - Xu,Kang-Ping, AU - Huang,Wei, AU - Tan,Jian-Bin, AU - Zhou,Ying-Jun, AU - Li,Fu-Shuang, AU - Huang,Zhao-Hui, AU - Liu,Bao-Chuan, AU - Tan,Gui-Shan, PY - 2006/5/26/pubmed PY - 2006/8/9/medline PY - 2006/5/26/entrez SP - 16 EP - 9 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 29 IS - 1 N2 - OBJECTIVE: To study the antihyperlipidemia effective constituent of Polygala fallax Hemsl. METHOD: Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant and the structures were elucidated by IR, NMR and MS spectroscopy. RESULT: Four triterpenoid saponins were isolated and determined as 3-O-beta-D-glucopyranosyl-(1--> 2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -beta-D-fucopyranosyl ester (I), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(3-O-acetyl)-beta-D-fucopyranosyl ester (II), 3-O-beta-D-glucopyranosyl-(1-->2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) -(4-O-acetyl) -beta-D-fucopyranosyl ester (II) and 3-O-beta-D-glucopyranosyl-(1--2) -beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4) -alpha-L-rhamnopyranosyl-(1-->2) - (3,4-diacetyl) -beta-D-fucopyranosyl ester (IV). CONCLUSIONS: The effective constituents of Polygala fallax Hemsl. reduced blood lipid especially plasma TG markedly. The authors have studied the chemical constituents of effective constituent systematically for the first time. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/16722311/[Study_on_the_antihyperlipidemia_effective_constituent_of_Polygala_fallax_Hemsl]_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -