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The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial.

Abstract

The study compared the effect of a sustained silver-release foam dressing (Contreet Foam) with a foam dressing (Allevyn Hydrocellular) without added silver in critically colonised venous leg ulcers with delayed healing. The study was a multicentre, open, randomised, controlled study lasting for 4 weeks. Ulcer area and healing were assessed weekly. Odour, maceration, absorption capacity and leakage were evaluated at dressing changes. All adverse events were recorded. One hundred and twenty-nine patients were included (Contreet Foam: 65, Allevyn Hydrocellular: 64). The two groups were comparable in all respects. After 4 weeks, there was a significantly greater reduction in ulcer area in the Contreet Foam group (45%) than in the Allevyn Hydrocellular group (25%). After 1 and 4 weeks, odour was present in significantly less of the ulcers in the Contreet Foam group (17% and 19%, respectively) compared with the Allevyn Hydrocellular group (47% and 39%, respectively) and at the final visit there were significantly fewer leakages in the Contreet Foam group (19%) compared with the Allevyn Hydrocellular group (49%). Also, less maceration was observed after 1 and 4 weeks in the Contreet Foam group (34% and 37%, respectively) compared with the Allevyn Hydrocellular group (55% and 48%, respectively). The occurrence and cause of adverse events were equally distributed between the study groups. The present study provides evidence of the superior performance of the silver-releasing dressing, Contreet Foam, compared with a traditional moist foam wound healing dressing in the treatment of critically colonised, chronic venous leg ulcers. The results of this randomised, controlled study suggest an important role of sustained silver-releasing dressings in the treatment of critically colonised chronic wounds.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Copenhagen Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark.

    , , , , , , , , , , , , , , , , ,

    Source

    International wound journal 2:1 2005 Mar pg 64-73

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Bandages, Hydrocolloid
    Delayed-Action Preparations
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Polyurethanes
    Quality of Life
    Silver Compounds
    Treatment Outcome
    Varicose Ulcer
    Wound Healing
    Wound Infection

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16722854

    Citation

    Jørgensen, Bo, et al. "The Silver-releasing Foam Dressing, Contreet Foam, Promotes Faster Healing of Critically Colonised Venous Leg Ulcers: a Randomised, Controlled Trial." International Wound Journal, vol. 2, no. 1, 2005, pp. 64-73.
    Jørgensen B, Price P, Andersen KE, et al. The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial. Int Wound J. 2005;2(1):64-73.
    Jørgensen, B., Price, P., Andersen, K. E., Gottrup, F., Bech-Thomsen, N., Scanlon, E., ... Sibbald, R. G. (2005). The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial. International Wound Journal, 2(1), pp. 64-73.
    Jørgensen B, et al. The Silver-releasing Foam Dressing, Contreet Foam, Promotes Faster Healing of Critically Colonised Venous Leg Ulcers: a Randomised, Controlled Trial. Int Wound J. 2005;2(1):64-73. PubMed PMID: 16722854.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial. AU - Jørgensen,Bo, AU - Price,Patricia, AU - Andersen,Klaus E, AU - Gottrup,Finn, AU - Bech-Thomsen,Niels, AU - Scanlon,Elizabeth, AU - Kirsner,Robert, AU - Rheinen,Henriette, AU - Roed-Petersen,Jytte, AU - Romanelli,Marco, AU - Jemec,Gregor, AU - Leaper,David J, AU - Neumann,Martino Ha, AU - Veraart,Joep, AU - Coerper,Stefan, AU - Agerslev,Rikke H, AU - Bendz,Susanne H, AU - Larsen,Jan R, AU - Sibbald,R Gary, PY - 2006/5/26/pubmed PY - 2006/6/28/medline PY - 2006/5/26/entrez SP - 64 EP - 73 JF - International wound journal JO - Int Wound J VL - 2 IS - 1 N2 - The study compared the effect of a sustained silver-release foam dressing (Contreet Foam) with a foam dressing (Allevyn Hydrocellular) without added silver in critically colonised venous leg ulcers with delayed healing. The study was a multicentre, open, randomised, controlled study lasting for 4 weeks. Ulcer area and healing were assessed weekly. Odour, maceration, absorption capacity and leakage were evaluated at dressing changes. All adverse events were recorded. One hundred and twenty-nine patients were included (Contreet Foam: 65, Allevyn Hydrocellular: 64). The two groups were comparable in all respects. After 4 weeks, there was a significantly greater reduction in ulcer area in the Contreet Foam group (45%) than in the Allevyn Hydrocellular group (25%). After 1 and 4 weeks, odour was present in significantly less of the ulcers in the Contreet Foam group (17% and 19%, respectively) compared with the Allevyn Hydrocellular group (47% and 39%, respectively) and at the final visit there were significantly fewer leakages in the Contreet Foam group (19%) compared with the Allevyn Hydrocellular group (49%). Also, less maceration was observed after 1 and 4 weeks in the Contreet Foam group (34% and 37%, respectively) compared with the Allevyn Hydrocellular group (55% and 48%, respectively). The occurrence and cause of adverse events were equally distributed between the study groups. The present study provides evidence of the superior performance of the silver-releasing dressing, Contreet Foam, compared with a traditional moist foam wound healing dressing in the treatment of critically colonised, chronic venous leg ulcers. The results of this randomised, controlled study suggest an important role of sustained silver-releasing dressings in the treatment of critically colonised chronic wounds. SN - 1742-4801 UR - https://www.unboundmedicine.com/medline/citation/16722854/The_silver_releasing_foam_dressing_Contreet_Foam_promotes_faster_healing_of_critically_colonised_venous_leg_ulcers:_a_randomised_controlled_trial_ L2 - https://doi.org/10.1111/j.1742-4801.2005.00084.x DB - PRIME DP - Unbound Medicine ER -