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MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia.
Am J Obstet Gynecol. 2006 Nov; 195(5):1398-403.AJ

Abstract

OBJECTIVE

We hypothesized that cardiac function would be reduced in a pregnant rat model of preeclampsia induced by L-NAME, a NOS inhibitor, and be reversed with magnesium sulfate prophylaxis.

STUDY DESIGN

Female Sprague-Dawley rats were bred in-house. On gestational day 17, rats were anesthetized and osmotic minipumps were implanted to continuously deliver saline, L-NAME, or L-NAME and MgSO4. On gestational day 21, hearts were isolated and perfused in the working mode using Krebs Henseleit buffer.

RESULTS

Pregnant rats treated with L-NAME displayed significant hypertension compared to the saline-treated controls (P < 0.05). Moreover, cardiac output and cardiac work were significantly reduced in the L-NAME-treated rats compared to controls (P < 0.05). In the L-NAME-treated rats given MgSO4, cardiac function remained normal.

CONCLUSION

Cardiac function is depressed in an animal model of preeclampsia induced by L-NAME infusion. MgSO4 prevented the reduction in cardiac function and is clearly beneficial in preserving normal heart function in preeclampsia.

Authors+Show Affiliations

Department of Physiology, Midwestern University, Arizona College of Osteopathic Medicine, Glendale, AZ 85308, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16723106

Citation

Coates, Brian J., et al. "MgSO4 Prevents Left Ventricular Dysfunction in an Animal Model of Preeclampsia." American Journal of Obstetrics and Gynecology, vol. 195, no. 5, 2006, pp. 1398-403.
Coates BJ, Broderick TL, Batia LM, et al. MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia. Am J Obstet Gynecol. 2006;195(5):1398-403.
Coates, B. J., Broderick, T. L., Batia, L. M., & Standley, C. A. (2006). MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia. American Journal of Obstetrics and Gynecology, 195(5), 1398-403.
Coates BJ, et al. MgSO4 Prevents Left Ventricular Dysfunction in an Animal Model of Preeclampsia. Am J Obstet Gynecol. 2006;195(5):1398-403. PubMed PMID: 16723106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia. AU - Coates,Brian J, AU - Broderick,Tom L, AU - Batia,Lyn M, AU - Standley,Cynthia A, Y1 - 2006/05/24/ PY - 2005/09/22/received PY - 2006/02/27/revised PY - 2006/02/27/accepted PY - 2006/5/26/pubmed PY - 2006/12/14/medline PY - 2006/5/26/entrez SP - 1398 EP - 403 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 195 IS - 5 N2 - OBJECTIVE: We hypothesized that cardiac function would be reduced in a pregnant rat model of preeclampsia induced by L-NAME, a NOS inhibitor, and be reversed with magnesium sulfate prophylaxis. STUDY DESIGN: Female Sprague-Dawley rats were bred in-house. On gestational day 17, rats were anesthetized and osmotic minipumps were implanted to continuously deliver saline, L-NAME, or L-NAME and MgSO4. On gestational day 21, hearts were isolated and perfused in the working mode using Krebs Henseleit buffer. RESULTS: Pregnant rats treated with L-NAME displayed significant hypertension compared to the saline-treated controls (P < 0.05). Moreover, cardiac output and cardiac work were significantly reduced in the L-NAME-treated rats compared to controls (P < 0.05). In the L-NAME-treated rats given MgSO4, cardiac function remained normal. CONCLUSION: Cardiac function is depressed in an animal model of preeclampsia induced by L-NAME infusion. MgSO4 prevented the reduction in cardiac function and is clearly beneficial in preserving normal heart function in preeclampsia. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/16723106/MgSO4_prevents_left_ventricular_dysfunction_in_an_animal_model_of_preeclampsia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(06)00293-6 DB - PRIME DP - Unbound Medicine ER -