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Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage.
FASEB J. 2006 Jul; 20(9):1567-9.FJ

Abstract

Oxidative stress is generated by a multitude of environmental and endogenous challenges such as radiation, inflammation, or psychoemotional stress. It also speeds the aging process. Graying is a prominent but little understood feature of aging. Intriguingly, the continuous melanin synthesis in the growing (anagen) hair follicle generates high oxidative stress. We therefore hypothesize that hair bulb melanocytes are especially susceptible to free radical-induced aging. To test this hypothesis, we subjected human scalp skin anagen hair follicles from graying individuals to macroscopic and immunohistomorphometric analysis and organ culture. We found evidence of melanocyte apoptosis and increased oxidative stress in the pigmentary unit of graying hair follicles. The "common" deletion, a marker mitochondrial DNA-deletion for accumulating oxidative stress damage, occurred most prominently in graying hair follicles. Cultured unpigmented hair follicles grew better than pigmented follicles of the same donors. Finally, cultured pigmented hair follicles exposed to exogenous oxidative stress (hydroquinone) showed increased melanocyte apoptosis in the hair bulb. We conclude that oxidative stress is high in hair follicle melanocytes and leads to their selective premature aging and apoptosis. The graying hair follicle, therefore, offers a unique model system to study oxidative stress and aging and to test antiaging therapeutics in their ability to slow down or even stop this process.

Authors+Show Affiliations

Cutaneous Neuroimmunology, Biomedical Research Center, Rm. Nr. 2.0549, University Medicine Charité, Virchow Campus, Humboldt University of Berlin, Augustenburger Platz 1, Berlin 13353, Germany. eva.peters@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16723385

Citation

Arck, Petra Clara, et al. "Towards a "free Radical Theory of Graying": Melanocyte Apoptosis in the Aging Human Hair Follicle Is an Indicator of Oxidative Stress Induced Tissue Damage." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 20, no. 9, 2006, pp. 1567-9.
Arck PC, Overall R, Spatz K, et al. Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 2006;20(9):1567-9.
Arck, P. C., Overall, R., Spatz, K., Liezman, C., Handjiski, B., Klapp, B. F., Birch-Machin, M. A., & Peters, E. M. (2006). Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 20(9), 1567-9.
Arck PC, et al. Towards a "free Radical Theory of Graying": Melanocyte Apoptosis in the Aging Human Hair Follicle Is an Indicator of Oxidative Stress Induced Tissue Damage. FASEB J. 2006;20(9):1567-9. PubMed PMID: 16723385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. AU - Arck,Petra Clara, AU - Overall,Rupert, AU - Spatz,Katharina, AU - Liezman,Christiane, AU - Handjiski,Bori, AU - Klapp,Burghard F, AU - Birch-Machin,Mark A, AU - Peters,Eva Milena Johanne, Y1 - 2006/05/24/ PY - 2006/5/26/pubmed PY - 2006/8/1/medline PY - 2006/5/26/entrez SP - 1567 EP - 9 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J VL - 20 IS - 9 N2 - Oxidative stress is generated by a multitude of environmental and endogenous challenges such as radiation, inflammation, or psychoemotional stress. It also speeds the aging process. Graying is a prominent but little understood feature of aging. Intriguingly, the continuous melanin synthesis in the growing (anagen) hair follicle generates high oxidative stress. We therefore hypothesize that hair bulb melanocytes are especially susceptible to free radical-induced aging. To test this hypothesis, we subjected human scalp skin anagen hair follicles from graying individuals to macroscopic and immunohistomorphometric analysis and organ culture. We found evidence of melanocyte apoptosis and increased oxidative stress in the pigmentary unit of graying hair follicles. The "common" deletion, a marker mitochondrial DNA-deletion for accumulating oxidative stress damage, occurred most prominently in graying hair follicles. Cultured unpigmented hair follicles grew better than pigmented follicles of the same donors. Finally, cultured pigmented hair follicles exposed to exogenous oxidative stress (hydroquinone) showed increased melanocyte apoptosis in the hair bulb. We conclude that oxidative stress is high in hair follicle melanocytes and leads to their selective premature aging and apoptosis. The graying hair follicle, therefore, offers a unique model system to study oxidative stress and aging and to test antiaging therapeutics in their ability to slow down or even stop this process. SN - 1530-6860 UR - https://www.unboundmedicine.com/medline/citation/16723385/Towards_a_"free_radical_theory_of_graying":_melanocyte_apoptosis_in_the_aging_human_hair_follicle_is_an_indicator_of_oxidative_stress_induced_tissue_damage_ DB - PRIME DP - Unbound Medicine ER -