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Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: a case-control study.
J Surg Oncol 2006; 93(8):624-8JS

Abstract

BACKGROUND

Gallstones are considered the most important risk factor for gallbladder cancer.

AIM

To identify differences in the number, weight, volume, and density of gallstones associated with chronic cholecystitis (CC), gallbladder dysplasia (GD), and gallbladder cancer (GBC).

METHODS

A total of 125 cases were selected, of which 93 had gallstones associated with GBC and 31 had gallstones associated with GD. The controls were those with CC, matched by sex and age. The number, weight, volume, and density of these gallstones were examined in order to determine differences and relative cancer risk.

RESULTS

Number: Multiple gallstones were present in over 76% of cases (GBC and GD) and controls (P = ns). The average number of multiple stones was 21 in GBC versus 14 in controls (P < 0.01). Weight: The average weight of the gallstones was 9.6 g in GBC versus 6.0 g in controls (P = 0.0004). The average weight in multiple stones over 10 g had strong association with GBC (P = 0.0006). Volume: The average volume was 11.7 and 6.48 ml in GBC and controls (P = 0.0002). Average volumes of 6, 8, and 10 ml had a relative cancer risk of 5, 7, and 11 times, respectively. Size: No differences were shown between GBC, GD, and controls.

CONCLUSIONS

The volume of gallstones associated with other risk factors of GBC may be helpful in prioritizing cholecystectomies in symptomatic patients.

Authors+Show Affiliations

Department of Pathology, Faculty of Medicine Universidad de la Frontera, Temuco, Chile. iroa@ufro.cl

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16724353

Citation

Roa, Iván, et al. "Gallstones and Gallbladder Cancer-volume and Weight of Gallstones Are Associated With Gallbladder Cancer: a Case-control Study." Journal of Surgical Oncology, vol. 93, no. 8, 2006, pp. 624-8.
Roa I, Ibacache G, Roa J, et al. Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: a case-control study. J Surg Oncol. 2006;93(8):624-8.
Roa, I., Ibacache, G., Roa, J., Araya, J., de Aretxabala, X., & Muñoz, S. (2006). Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: a case-control study. Journal of Surgical Oncology, 93(8), pp. 624-8.
Roa I, et al. Gallstones and Gallbladder Cancer-volume and Weight of Gallstones Are Associated With Gallbladder Cancer: a Case-control Study. J Surg Oncol. 2006 Jun 15;93(8):624-8. PubMed PMID: 16724353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: a case-control study. AU - Roa,Iván, AU - Ibacache,Gilda, AU - Roa,Juan, AU - Araya,Juan, AU - de Aretxabala,Xabier, AU - Muñoz,Sergio, PY - 2006/5/26/pubmed PY - 2006/6/29/medline PY - 2006/5/26/entrez SP - 624 EP - 8 JF - Journal of surgical oncology JO - J Surg Oncol VL - 93 IS - 8 N2 - BACKGROUND: Gallstones are considered the most important risk factor for gallbladder cancer. AIM: To identify differences in the number, weight, volume, and density of gallstones associated with chronic cholecystitis (CC), gallbladder dysplasia (GD), and gallbladder cancer (GBC). METHODS: A total of 125 cases were selected, of which 93 had gallstones associated with GBC and 31 had gallstones associated with GD. The controls were those with CC, matched by sex and age. The number, weight, volume, and density of these gallstones were examined in order to determine differences and relative cancer risk. RESULTS: Number: Multiple gallstones were present in over 76% of cases (GBC and GD) and controls (P = ns). The average number of multiple stones was 21 in GBC versus 14 in controls (P < 0.01). Weight: The average weight of the gallstones was 9.6 g in GBC versus 6.0 g in controls (P = 0.0004). The average weight in multiple stones over 10 g had strong association with GBC (P = 0.0006). Volume: The average volume was 11.7 and 6.48 ml in GBC and controls (P = 0.0002). Average volumes of 6, 8, and 10 ml had a relative cancer risk of 5, 7, and 11 times, respectively. Size: No differences were shown between GBC, GD, and controls. CONCLUSIONS: The volume of gallstones associated with other risk factors of GBC may be helpful in prioritizing cholecystectomies in symptomatic patients. SN - 0022-4790 UR - https://www.unboundmedicine.com/medline/citation/16724353/Gallstones_and_gallbladder_cancer_volume_and_weight_of_gallstones_are_associated_with_gallbladder_cancer:_a_case_control_study_ L2 - https://doi.org/10.1002/jso.20528 DB - PRIME DP - Unbound Medicine ER -