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Epidermal effects of tretinoin and isotretinoin: influence of isomerism.
Pharmazie. 2006 May; 61(5):453-6.P

Abstract

The efficacy of tretinoin is well established in the treatment of acne and photoaged skin, however as a typical side effect of tretinoin treatment most patients develop a low-grade irritant dermatitis. Since isotretinoin topical treatment usually shows much lower incidence and intensity of adverse effects than tretinoin topical treatment, histological studies are needed to scientifically evaluate the effects of isotretinoin application on epidermis and also to assess if it can be used in anti-aging products as an alternative to tretinoin. Thus, the aim of this study was to compare the effects of topical use of tretinoin or isotretinoin on hairless mice epidermis, using appropriate histopathological and histometric techniques, in order to evaluate the influence of isomerism on skin effects. For this, gel cream formulations containing or not 0.05% tretinoin or 0.05% isotretinoin were applied in the dorsum of hairless mice, once a day for seven days. Histopathological evaluation, viable epidermal and horny layer thicknesses as well as the number of epidermal cell layers were determined. Our results showed that tretinoin and isotretinoin were effective in the enhancement of viable epidermis thickness and number of epidermal cell layers, suggesting that they could be used for stimulation of cellular renewal. However isomerism influenced skin effects since isotretinoin had more pronounced effects than tretinoin in viable epidermis. In addition only isotretinoin treatment enhanced horny layer thickness when compared to the gel cream treatment.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, University of São Paulo, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16724545

Citation

Tadini, K A., et al. "Epidermal Effects of Tretinoin and Isotretinoin: Influence of Isomerism." Die Pharmazie, vol. 61, no. 5, 2006, pp. 453-6.
Tadini KA, Gaspar LR, Maia Campos PM. Epidermal effects of tretinoin and isotretinoin: influence of isomerism. Pharmazie. 2006;61(5):453-6.
Tadini, K. A., Gaspar, L. R., & Maia Campos, P. M. (2006). Epidermal effects of tretinoin and isotretinoin: influence of isomerism. Die Pharmazie, 61(5), 453-6.
Tadini KA, Gaspar LR, Maia Campos PM. Epidermal Effects of Tretinoin and Isotretinoin: Influence of Isomerism. Pharmazie. 2006;61(5):453-6. PubMed PMID: 16724545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidermal effects of tretinoin and isotretinoin: influence of isomerism. AU - Tadini,K A, AU - Gaspar,L R, AU - Maia Campos,P M B G, PY - 2006/5/27/pubmed PY - 2006/7/6/medline PY - 2006/5/27/entrez SP - 453 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 61 IS - 5 N2 - The efficacy of tretinoin is well established in the treatment of acne and photoaged skin, however as a typical side effect of tretinoin treatment most patients develop a low-grade irritant dermatitis. Since isotretinoin topical treatment usually shows much lower incidence and intensity of adverse effects than tretinoin topical treatment, histological studies are needed to scientifically evaluate the effects of isotretinoin application on epidermis and also to assess if it can be used in anti-aging products as an alternative to tretinoin. Thus, the aim of this study was to compare the effects of topical use of tretinoin or isotretinoin on hairless mice epidermis, using appropriate histopathological and histometric techniques, in order to evaluate the influence of isomerism on skin effects. For this, gel cream formulations containing or not 0.05% tretinoin or 0.05% isotretinoin were applied in the dorsum of hairless mice, once a day for seven days. Histopathological evaluation, viable epidermal and horny layer thicknesses as well as the number of epidermal cell layers were determined. Our results showed that tretinoin and isotretinoin were effective in the enhancement of viable epidermis thickness and number of epidermal cell layers, suggesting that they could be used for stimulation of cellular renewal. However isomerism influenced skin effects since isotretinoin had more pronounced effects than tretinoin in viable epidermis. In addition only isotretinoin treatment enhanced horny layer thickness when compared to the gel cream treatment. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/16724545/Epidermal_effects_of_tretinoin_and_isotretinoin:_influence_of_isomerism_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:16724545 DB - PRIME DP - Unbound Medicine ER -