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Microbial O-demethylation, hydroxylation, sulfation, and ribosylation of a xanthone derivative from Halenia elliptica.
J Nat Prod. 2006 May; 69(5):811-4.JN

Abstract

1-Hydroxy-2,3,5-trimethoxyxanthone (1), one of the major xanthone derivatives isolated from Halenia elliptica, was biotransformed by two fungi, Trichothecium roseum and Paecilomyces marquandii. Transformation of 1 by T. roseumgave 1,5-dihydroxy-2,3-dimethoxyxanthone (2), 5-O-sulfate-1-hydroxy-2,3-dimethoxyxanthone (3), 5-O-sulfate-1-hydroxy-2,3,7-trimethoxyxanthone (4), 5-O-beta-ribofuranosyl-1-hydroxy-2,3-dimethoxyxanthone (5), and 1,5,6-trihydroxy-2,3-dimethoxyxanthone (6). Compound 2 was also formed by P. marquandii. The structures of the isolated compounds were elucidated by spectroscopic analyses. Among the five microbial-converted compounds, 3, 4, 5, and 6 are new compounds.

Authors+Show Affiliations

Yuan W
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Zhang LP
No affiliation info available
Cheng KD
No affiliation info available
Zhu P
No affiliation info available
Wang Q
No affiliation info available
He HX
No affiliation info available
Zhu HX
No affiliation info available

MeSH

AscomycotaBiotransformationGentianaceaeHydroxylationMolecular StructurePaecilomycesPlants, MedicinalXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16724847

Citation

Yuan, Wei, et al. "Microbial O-demethylation, Hydroxylation, Sulfation, and Ribosylation of a Xanthone Derivative From Halenia Elliptica." Journal of Natural Products, vol. 69, no. 5, 2006, pp. 811-4.
Yuan W, Zhang LP, Cheng KD, et al. Microbial O-demethylation, hydroxylation, sulfation, and ribosylation of a xanthone derivative from Halenia elliptica. J Nat Prod. 2006;69(5):811-4.
Yuan, W., Zhang, L. P., Cheng, K. D., Zhu, P., Wang, Q., He, H. X., & Zhu, H. X. (2006). Microbial O-demethylation, hydroxylation, sulfation, and ribosylation of a xanthone derivative from Halenia elliptica. Journal of Natural Products, 69(5), 811-4.
Yuan W, et al. Microbial O-demethylation, Hydroxylation, Sulfation, and Ribosylation of a Xanthone Derivative From Halenia Elliptica. J Nat Prod. 2006;69(5):811-4. PubMed PMID: 16724847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial O-demethylation, hydroxylation, sulfation, and ribosylation of a xanthone derivative from Halenia elliptica. AU - Yuan,Wei, AU - Zhang,Li-Ping, AU - Cheng,Ke-Di, AU - Zhu,Ping, AU - Wang,Quan, AU - He,Hui-Xia, AU - Zhu,Hui-Xin, PY - 2006/5/27/pubmed PY - 2006/7/14/medline PY - 2006/5/27/entrez SP - 811 EP - 4 JF - Journal of natural products JO - J Nat Prod VL - 69 IS - 5 N2 - 1-Hydroxy-2,3,5-trimethoxyxanthone (1), one of the major xanthone derivatives isolated from Halenia elliptica, was biotransformed by two fungi, Trichothecium roseum and Paecilomyces marquandii. Transformation of 1 by T. roseumgave 1,5-dihydroxy-2,3-dimethoxyxanthone (2), 5-O-sulfate-1-hydroxy-2,3-dimethoxyxanthone (3), 5-O-sulfate-1-hydroxy-2,3,7-trimethoxyxanthone (4), 5-O-beta-ribofuranosyl-1-hydroxy-2,3-dimethoxyxanthone (5), and 1,5,6-trihydroxy-2,3-dimethoxyxanthone (6). Compound 2 was also formed by P. marquandii. The structures of the isolated compounds were elucidated by spectroscopic analyses. Among the five microbial-converted compounds, 3, 4, 5, and 6 are new compounds. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16724847/Microbial_O_demethylation_hydroxylation_sulfation_and_ribosylation_of_a_xanthone_derivative_from_Halenia_elliptica_ DB - PRIME DP - Unbound Medicine ER -