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The links between allergy and otitis media with effusion.
Curr Opin Otolaryngol Head Neck Surg. 2006 Jun; 14(3):187-90.CO

Abstract

PURPOSE OF REVIEW

In this review we will examine evidence indicating that allergic inflammation is present in middle ear effusion. We will also discuss several of the problems relating to the diagnosis of allergy and allergic sensitization, and why anti-allergy treatments have been unsuccessful. This will provide a rationale for future studies in the field linking allergic inflammation with otitis media with effusion.

RECENT FINDINGS

Recent findings in atopic children demonstrated higher levels of eosinophils, T lymphocytes, and interleukin-4+ and interleukin-5+ cells compared with nonatopic patients. T-helper 2 cells and cytokines were found not only in middle ear effusions in atopic children but also in specimens from adenoid tissue. This demonstrates a strong correlation between allergic reaction in the middle ear and the upper airway.

SUMMARY

In summary, as our knowledge of the allergic and nonallergic influences on inflammation broadens, the paradigms of treatment may be altered. The accumulating experimental and clinical data suggest that it may be wiser to screen every child with otitis media with effusion for allergic rhinitis and ultimately to manage those with allergic inflammation differently to nonatopic individuals with otitis media with effusion.

Authors+Show Affiliations

Department of Otolaryngology, McGill University, Montreal, Canada. ted.tewfik@mcgill.caNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16728898

Citation

Tewfik, Ted L., and Bruce Mazer. "The Links Between Allergy and Otitis Media With Effusion." Current Opinion in Otolaryngology & Head and Neck Surgery, vol. 14, no. 3, 2006, pp. 187-90.
Tewfik TL, Mazer B. The links between allergy and otitis media with effusion. Curr Opin Otolaryngol Head Neck Surg. 2006;14(3):187-90.
Tewfik, T. L., & Mazer, B. (2006). The links between allergy and otitis media with effusion. Current Opinion in Otolaryngology & Head and Neck Surgery, 14(3), 187-90.
Tewfik TL, Mazer B. The Links Between Allergy and Otitis Media With Effusion. Curr Opin Otolaryngol Head Neck Surg. 2006;14(3):187-90. PubMed PMID: 16728898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The links between allergy and otitis media with effusion. AU - Tewfik,Ted L, AU - Mazer,Bruce, PY - 2006/5/27/pubmed PY - 2008/1/25/medline PY - 2006/5/27/entrez SP - 187 EP - 90 JF - Current opinion in otolaryngology & head and neck surgery JO - Curr Opin Otolaryngol Head Neck Surg VL - 14 IS - 3 N2 - PURPOSE OF REVIEW: In this review we will examine evidence indicating that allergic inflammation is present in middle ear effusion. We will also discuss several of the problems relating to the diagnosis of allergy and allergic sensitization, and why anti-allergy treatments have been unsuccessful. This will provide a rationale for future studies in the field linking allergic inflammation with otitis media with effusion. RECENT FINDINGS: Recent findings in atopic children demonstrated higher levels of eosinophils, T lymphocytes, and interleukin-4+ and interleukin-5+ cells compared with nonatopic patients. T-helper 2 cells and cytokines were found not only in middle ear effusions in atopic children but also in specimens from adenoid tissue. This demonstrates a strong correlation between allergic reaction in the middle ear and the upper airway. SUMMARY: In summary, as our knowledge of the allergic and nonallergic influences on inflammation broadens, the paradigms of treatment may be altered. The accumulating experimental and clinical data suggest that it may be wiser to screen every child with otitis media with effusion for allergic rhinitis and ultimately to manage those with allergic inflammation differently to nonatopic individuals with otitis media with effusion. SN - 1531-6998 UR - https://www.unboundmedicine.com/medline/citation/16728898/The_links_between_allergy_and_otitis_media_with_effusion_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16728898.ui DB - PRIME DP - Unbound Medicine ER -
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