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Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans.
Cell Death Differ. 2006 Dec; 13(12):2129-39.CD

Abstract

In Caenorhabditis elegans, several distinct apoptosis pathways have been characterized in the germline. The physiological pathway is though to eliminate excess germ cells during oogenesis to maintain gonad homeostasis and it is activated by unknown mechanisms. The DNA damage-induced germ cell apoptosis occurs in response to genotoxic agents and involves the proteins EGL-1 and CED-13, and the DNA damage response protein p53. Germ cell apoptosis can also be induced in response to pathogen infection through an EGL-1 dependent pathway. To gain insight into the mechanism and functions of germ cell apoptosis, we investigated whether and how other forms of stress induce this cell death. We found that oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and EGL-1 independent pathway. We also learned that the MAPK kinases MEK-1 and SEK-1, and the p53 antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis. We conclude that in C. elegans responses to various stresses that do not involve genotoxicity include an increase in germ cell apoptosis through the physiological pathway.

Authors+Show Affiliations

Salinas LS
Departamento de Biología Celular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-600, México, DF 04510, Mexico.
Maldonado E
No affiliation info available
Navarro RE
No affiliation info available

MeSH

AnimalsApoptosisCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA DamageFemaleGene Expression RegulationGerm CellsHeat Stress DisordersHerbicidesMAP Kinase Kinase 1MAP Kinase Kinase 4OogenesisOsmotic PressureOxidative StressParaquatProto-Oncogene Proteins c-ablReactive Oxygen SpeciesRepressor ProteinsSignal TransductionTumor Suppressor Protein p53

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16729024

Citation

Salinas, L S., et al. "Stress-induced Germ Cell Apoptosis By a P53 Independent Pathway in Caenorhabditis Elegans." Cell Death and Differentiation, vol. 13, no. 12, 2006, pp. 2129-39.
Salinas LS, Maldonado E, Navarro RE. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell Death Differ. 2006;13(12):2129-39.
Salinas, L. S., Maldonado, E., & Navarro, R. E. (2006). Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell Death and Differentiation, 13(12), 2129-39.
Salinas LS, Maldonado E, Navarro RE. Stress-induced Germ Cell Apoptosis By a P53 Independent Pathway in Caenorhabditis Elegans. Cell Death Differ. 2006;13(12):2129-39. PubMed PMID: 16729024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. AU - Salinas,L S, AU - Maldonado,E, AU - Navarro,R E, Y1 - 2006/05/26/ PY - 2006/5/27/pubmed PY - 2007/2/3/medline PY - 2006/5/27/entrez SP - 2129 EP - 39 JF - Cell death and differentiation JO - Cell Death Differ VL - 13 IS - 12 N2 - In Caenorhabditis elegans, several distinct apoptosis pathways have been characterized in the germline. The physiological pathway is though to eliminate excess germ cells during oogenesis to maintain gonad homeostasis and it is activated by unknown mechanisms. The DNA damage-induced germ cell apoptosis occurs in response to genotoxic agents and involves the proteins EGL-1 and CED-13, and the DNA damage response protein p53. Germ cell apoptosis can also be induced in response to pathogen infection through an EGL-1 dependent pathway. To gain insight into the mechanism and functions of germ cell apoptosis, we investigated whether and how other forms of stress induce this cell death. We found that oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and EGL-1 independent pathway. We also learned that the MAPK kinases MEK-1 and SEK-1, and the p53 antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis. We conclude that in C. elegans responses to various stresses that do not involve genotoxicity include an increase in germ cell apoptosis through the physiological pathway. SN - 1350-9047 UR - https://www.unboundmedicine.com/medline/citation/16729024/Stress_induced_germ_cell_apoptosis_by_a_p53_independent_pathway_in_Caenorhabditis_elegans_ DB - PRIME DP - Unbound Medicine ER -