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In vitro inhibition of human influenza A virus replication by chloroquine.
Virol J. 2006 May 29; 3:39.VJ

Abstract

Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.

Links

Publisher Full Text
ncbi.nlm.nih.gov
virologyj.biomedcentral.com
PMC Free PDF

Authors+Show Affiliations

Ooi EE
Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, #09-01, 117510, Singapore. oengeong@dso.org.sg
Chew JS
No affiliation info available
Loh JP
No affiliation info available
Chua RC
No affiliation info available

MeSH

ChloroquineHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeMicrobial Sensitivity TestsVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16729896

Citation

Ooi, Eng Eong, et al. "In Vitro Inhibition of Human Influenza a Virus Replication By Chloroquine." Virology Journal, vol. 3, 2006, p. 39.
Ooi EE, Chew JS, Loh JP, et al. In vitro inhibition of human influenza A virus replication by chloroquine. Virol J. 2006;3:39.
Ooi, E. E., Chew, J. S., Loh, J. P., & Chua, R. C. (2006). In vitro inhibition of human influenza A virus replication by chloroquine. Virology Journal, 3, 39.
Ooi EE, et al. In Vitro Inhibition of Human Influenza a Virus Replication By Chloroquine. Virol J. 2006 May 29;3:39. PubMed PMID: 16729896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro inhibition of human influenza A virus replication by chloroquine. AU - Ooi,Eng Eong, AU - Chew,Janet Seok Wei, AU - Loh,Jin Phang, AU - Chua,Robert C S, Y1 - 2006/05/29/ PY - 2006/03/31/received PY - 2006/05/29/accepted PY - 2006/5/30/pubmed PY - 2006/10/19/medline PY - 2006/5/30/entrez SP - 39 EP - 39 JF - Virology journal JO - Virol. J. VL - 3 N2 - Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness. SN - 1743-422X UR - https://www.unboundmedicine.com/medline/citation/16729896/full_citation L2 - https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-3-39 DB - PRIME DP - Unbound Medicine ER -