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In vitro inhibition of human influenza A virus replication by chloroquine.Virol J. 2006 May 29; 3:39.VJ
Abstract
Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.
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MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
16729896
Citation
Ooi, Eng Eong, et al. "In Vitro Inhibition of Human Influenza a Virus Replication By Chloroquine." Virology Journal, vol. 3, 2006, p. 39.
Ooi EE, Chew JS, Loh JP, et al. In vitro inhibition of human influenza A virus replication by chloroquine. Virol J. 2006;3:39.
Ooi, E. E., Chew, J. S., Loh, J. P., & Chua, R. C. (2006). In vitro inhibition of human influenza A virus replication by chloroquine. Virology Journal, 3, 39.
Ooi EE, et al. In Vitro Inhibition of Human Influenza a Virus Replication By Chloroquine. Virol J. 2006 May 29;3:39. PubMed PMID: 16729896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - In vitro inhibition of human influenza A virus replication by chloroquine.
AU - Ooi,Eng Eong,
AU - Chew,Janet Seok Wei,
AU - Loh,Jin Phang,
AU - Chua,Robert C S,
Y1 - 2006/05/29/
PY - 2006/03/31/received
PY - 2006/05/29/accepted
PY - 2006/5/30/pubmed
PY - 2006/10/19/medline
PY - 2006/5/30/entrez
SP - 39
EP - 39
JF - Virology journal
JO - Virol J
VL - 3
N2 - Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.
SN - 1743-422X
UR - https://www.unboundmedicine.com/medline/citation/16729896/full_citation
L2 - https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-3-39
DB - PRIME
DP - Unbound Medicine
ER -