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Modulation of fear-potentiated startle and vocalizations in juvenile rhesus monkeys by morphine, diazepam, and buspirone.
Biol Psychiatry. 2007 Feb 01; 61(3):389-95.BP

Abstract

BACKGROUND

Modulation of the acoustic startle response by aversive sensory stimulation is a simple and objective indicator of emotionality in rodents and human beings that has been extremely valuable for the analysis of neural systems associated with fear and anxiety. We have described a paradigm for measuring fear-potentiated, whole-body acoustic startle in nonhuman primates and have developed a protocol for maintaining fear-potentiated startle over repeated sessions with minimal extinction to allow measurement of pharmacological effects on fear-potentiated startle by using within-subjects designs in relatively small groups of monkeys.

METHODS

A novel, within-subjects testing protocol was used to examine the effects of three compounds in rhesus monkeys that have anxiolytic effects in rodents on fear-potentiated startle but that differ in their mechanism of action. Spontaneous vocalizations during testing also were recorded. Juvenile monkeys that were trained to associate a visual stimulus with a fear-inducing air blast to the face were tested after acute administration of different doses of buspirone diazepam, morphine, or vehicle.

RESULTS

Monkeys rapidly developed a robust and persistent elevation of startle response in the presence of the CS during repeated testing sessions. Diazepam and morphine produced dose-related reductions of fear-potentiated startle. Buspirone did not significantly reduce fear-potentiated startle at the doses tested, although a trend was evident at the highest dose. All drugs reduced rates of coo vocalizations during startle testing.

CONCLUSIONS

These fear-potentiated startle results suggest that rhesus monkeys have a pharmacological profile with respect to these compounds that is closer to humans than to rats. This demonstrates the value of examining the effects of drugs on fear-potentiated startle in nonhuman primates.

Authors+Show Affiliations

Yerkes National Primate Research Center, Psychiatry and Behavioral Science, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia, USA. jameswinslow@mail.nih.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16730332

Citation

Winslow, James T., et al. "Modulation of Fear-potentiated Startle and Vocalizations in Juvenile Rhesus Monkeys By Morphine, Diazepam, and Buspirone." Biological Psychiatry, vol. 61, no. 3, 2007, pp. 389-95.
Winslow JT, Noble PL, Davis M. Modulation of fear-potentiated startle and vocalizations in juvenile rhesus monkeys by morphine, diazepam, and buspirone. Biol Psychiatry. 2007;61(3):389-95.
Winslow, J. T., Noble, P. L., & Davis, M. (2007). Modulation of fear-potentiated startle and vocalizations in juvenile rhesus monkeys by morphine, diazepam, and buspirone. Biological Psychiatry, 61(3), 389-95.
Winslow JT, Noble PL, Davis M. Modulation of Fear-potentiated Startle and Vocalizations in Juvenile Rhesus Monkeys By Morphine, Diazepam, and Buspirone. Biol Psychiatry. 2007 Feb 1;61(3):389-95. PubMed PMID: 16730332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of fear-potentiated startle and vocalizations in juvenile rhesus monkeys by morphine, diazepam, and buspirone. AU - Winslow,James T, AU - Noble,Pamela L, AU - Davis,Michael, Y1 - 2006/05/30/ PY - 2005/11/02/received PY - 2006/03/06/revised PY - 2006/03/06/accepted PY - 2006/5/30/pubmed PY - 2007/3/21/medline PY - 2006/5/30/entrez SP - 389 EP - 95 JF - Biological psychiatry JO - Biol Psychiatry VL - 61 IS - 3 N2 - BACKGROUND: Modulation of the acoustic startle response by aversive sensory stimulation is a simple and objective indicator of emotionality in rodents and human beings that has been extremely valuable for the analysis of neural systems associated with fear and anxiety. We have described a paradigm for measuring fear-potentiated, whole-body acoustic startle in nonhuman primates and have developed a protocol for maintaining fear-potentiated startle over repeated sessions with minimal extinction to allow measurement of pharmacological effects on fear-potentiated startle by using within-subjects designs in relatively small groups of monkeys. METHODS: A novel, within-subjects testing protocol was used to examine the effects of three compounds in rhesus monkeys that have anxiolytic effects in rodents on fear-potentiated startle but that differ in their mechanism of action. Spontaneous vocalizations during testing also were recorded. Juvenile monkeys that were trained to associate a visual stimulus with a fear-inducing air blast to the face were tested after acute administration of different doses of buspirone diazepam, morphine, or vehicle. RESULTS: Monkeys rapidly developed a robust and persistent elevation of startle response in the presence of the CS during repeated testing sessions. Diazepam and morphine produced dose-related reductions of fear-potentiated startle. Buspirone did not significantly reduce fear-potentiated startle at the doses tested, although a trend was evident at the highest dose. All drugs reduced rates of coo vocalizations during startle testing. CONCLUSIONS: These fear-potentiated startle results suggest that rhesus monkeys have a pharmacological profile with respect to these compounds that is closer to humans than to rats. This demonstrates the value of examining the effects of drugs on fear-potentiated startle in nonhuman primates. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16730332/Modulation_of_fear_potentiated_startle_and_vocalizations_in_juvenile_rhesus_monkeys_by_morphine_diazepam_and_buspirone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)00377-5 DB - PRIME DP - Unbound Medicine ER -