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Oral contraceptive use and risk of fractures.
Contraception 2006; 73(6):571-6C

Abstract

INTRODUCTION

Prior studies have suggested that oral contraceptives (OCs) may be associated with an increased fracture risk. However, the previous studies have only performed a limited adjustment for other potential risk factors.

SUBJECTS AND METHODS

All women with a fracture (n=64,548) in the year 2000 in Denmark served as cases. For each case, three age-matched controls were randomly drawn from the general population (n=193,641). Exposure was use of OCs between January 1, 1996, and December 31, 2000. Adjustments were made for use of other drugs, pregnancy, prior fracture, other diseases and social variables.

RESULTS

In the unadjusted analysis, use of OCs in low dose was associated with a small increase in overall fracture risk. However, upon adjustment, no increase in fracture risk could be demonstrated in any age or dose group.

CONCLUSION

Oral contraceptives are not associated with an increase or a decrease in fracture risk. Any change in fracture risk may be due to confounders.

Authors+Show Affiliations

Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Amtssygehus, DK-8000 Aarhus, Denmark. p-vest@post4.tele.dkNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16730486

Citation

Vestergaard, Peter, et al. "Oral Contraceptive Use and Risk of Fractures." Contraception, vol. 73, no. 6, 2006, pp. 571-6.
Vestergaard P, Rejnmark L, Mosekilde L. Oral contraceptive use and risk of fractures. Contraception. 2006;73(6):571-6.
Vestergaard, P., Rejnmark, L., & Mosekilde, L. (2006). Oral contraceptive use and risk of fractures. Contraception, 73(6), pp. 571-6.
Vestergaard P, Rejnmark L, Mosekilde L. Oral Contraceptive Use and Risk of Fractures. Contraception. 2006;73(6):571-6. PubMed PMID: 16730486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptive use and risk of fractures. AU - Vestergaard,Peter, AU - Rejnmark,Lars, AU - Mosekilde,Leif, Y1 - 2006/03/13/ PY - 2005/06/28/received PY - 2006/01/18/revised PY - 2006/01/18/accepted PY - 2006/5/30/pubmed PY - 2006/10/25/medline PY - 2006/5/30/entrez SP - 571 EP - 6 JF - Contraception JO - Contraception VL - 73 IS - 6 N2 - INTRODUCTION: Prior studies have suggested that oral contraceptives (OCs) may be associated with an increased fracture risk. However, the previous studies have only performed a limited adjustment for other potential risk factors. SUBJECTS AND METHODS: All women with a fracture (n=64,548) in the year 2000 in Denmark served as cases. For each case, three age-matched controls were randomly drawn from the general population (n=193,641). Exposure was use of OCs between January 1, 1996, and December 31, 2000. Adjustments were made for use of other drugs, pregnancy, prior fracture, other diseases and social variables. RESULTS: In the unadjusted analysis, use of OCs in low dose was associated with a small increase in overall fracture risk. However, upon adjustment, no increase in fracture risk could be demonstrated in any age or dose group. CONCLUSION: Oral contraceptives are not associated with an increase or a decrease in fracture risk. Any change in fracture risk may be due to confounders. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/16730486/Oral_contraceptive_use_and_risk_of_fractures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(06)00033-3 DB - PRIME DP - Unbound Medicine ER -