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Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based study.
Comput Biol Med. 2007 Jul; 37(7):1020-35.CB

Abstract

A dynamic model of ocular accommodation is used to simulate the stability and dynamic performance of accommodating intraocular lenses (A-IOLs) that replace the hardened natural ocular lens that is unable to change focus. Accommodation simulations of an older eye with A-IOL materials having biomechanical properties of a younger eye illustrate overshoots and oscillations resulting from decreased visco-elasticity of the A-IOL. Stable dynamics of an A-IOL are restored by adaptation of phasic and tonic neural-control properties of accommodation. Simulations indicate that neural control must be recalibrated to avoid unstable dynamic accommodation with A-IOLs. An interactive web-model of A-IOL illustrating these properties is available at http://schorlab.berkeley.edu.

Authors+Show Affiliations

Vision Science group, School of Optometry, University of California at Berkeley, Berkeley, CA 94720-2020, USA. schor@socrates.berkeley.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16730691

Citation

Schor, Clifton M., et al. "Dynamic Performance of Accommodating Intraocular Lenses in a Negative Feedback Control System: a Simulation-based Study." Computers in Biology and Medicine, vol. 37, no. 7, 2007, pp. 1020-35.
Schor CM, Bharadwaj SR, Burns CD. Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based study. Comput Biol Med. 2007;37(7):1020-35.
Schor, C. M., Bharadwaj, S. R., & Burns, C. D. (2007). Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based study. Computers in Biology and Medicine, 37(7), 1020-35.
Schor CM, Bharadwaj SR, Burns CD. Dynamic Performance of Accommodating Intraocular Lenses in a Negative Feedback Control System: a Simulation-based Study. Comput Biol Med. 2007;37(7):1020-35. PubMed PMID: 16730691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based study. AU - Schor,Clifton M, AU - Bharadwaj,Shrikant R, AU - Burns,Christopher D, Y1 - 2006/05/30/ PY - 2006/01/16/received PY - 2006/03/21/revised PY - 2006/03/30/accepted PY - 2006/5/30/pubmed PY - 2007/10/12/medline PY - 2006/5/30/entrez SP - 1020 EP - 35 JF - Computers in biology and medicine JO - Comput. Biol. Med. VL - 37 IS - 7 N2 - A dynamic model of ocular accommodation is used to simulate the stability and dynamic performance of accommodating intraocular lenses (A-IOLs) that replace the hardened natural ocular lens that is unable to change focus. Accommodation simulations of an older eye with A-IOL materials having biomechanical properties of a younger eye illustrate overshoots and oscillations resulting from decreased visco-elasticity of the A-IOL. Stable dynamics of an A-IOL are restored by adaptation of phasic and tonic neural-control properties of accommodation. Simulations indicate that neural control must be recalibrated to avoid unstable dynamic accommodation with A-IOLs. An interactive web-model of A-IOL illustrating these properties is available at http://schorlab.berkeley.edu. SN - 0010-4825 UR - https://www.unboundmedicine.com/medline/citation/16730691/Dynamic_performance_of_accommodating_intraocular_lenses_in_a_negative_feedback_control_system:_a_simulation_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-4825(06)00052-7 DB - PRIME DP - Unbound Medicine ER -