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Possibilities of newer ALAD polymorphism influencing human susceptibility to effects of inorganic lead on the neurobehavioral functions.
Neurotoxicology. 2007 Mar; 28(2):312-7.N

Abstract

OBJECTIVE

A cross-sectional study was conducted to study the association between some new ALAD polymorphism and susceptibility to effects of inorganic lead on the neurobehavioral functions.

METHOD

We recruited 120 healthy male workers with lead exposure in a factory which manufacture lead stabilizer. The ALAD SNPs studied were HpyCH4, HpyIV RFLP in intron 6, Rsa and Msp RFLP in exon 4, Sau3A in intron 12 and Rsa39488 in exon 5. The World Health Organization Neurobehavioral Core Test Battery (WHO-NCTB) and a few other tests were used. General linear model (GLM) was applied to compare outcome scores between subgroups of each ALAD SNP while controlling for possible confounders.

RESULTS

The mean age of the workers was 39.7 years (S.D. 10.7), mean exposure duration of 10.2 years (S.D. 7.9) and mean blood lead of 22.1 microg/dl (S.D. 9.4). Among the 6 SNPs studied, Rsa and Rsa39488 appear to be the main candidate SNPs. Workers with Rsa and Rsa39488 ALAD 2-2 genotypes fare significantly better in the Aiming Pursue Test Correct (AC), Groove Peg Board non-preferred hand (GPNP), Groove Peg Board Mean (GPM), San Ana Preferred Hand (SAP), San Ana Both Hands (SAB) and AC, GPNH, GPM, Digit Symbol (DIS) tests; respectively compared to Rsa and Rsa39488 ALAD 1-1/1-2 genotypes adjusted for age, race, exposure duration and blood lead levels.

CONCLUSION

The presence of the homozygote Rsa and Rsa39488 ALAD 2-2 seems to offer some protection against the effect of lead on motor dexterity function. While it may appear that newer ALAD polymorphism other than the commonly reported Msp SNP might influence human susceptibility to effects of inorganic lead on the neurobehavioral functions further study involving a larger cohort of workers with Rsa and Rsa39488 ALAD2 allele would be needed to confirm this inference.

Authors+Show Affiliations

Department of Community, Occupational & Family Medicine, National University of Singapore, Singapore, Republic of Singapore. cofcse@nus.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16730797

Citation

Chia, Sin-Eng, et al. "Possibilities of Newer ALAD Polymorphism Influencing Human Susceptibility to Effects of Inorganic Lead On the Neurobehavioral Functions." Neurotoxicology, vol. 28, no. 2, 2007, pp. 312-7.
Chia SE, Huijun Z, Theng TM, et al. Possibilities of newer ALAD polymorphism influencing human susceptibility to effects of inorganic lead on the neurobehavioral functions. Neurotoxicology. 2007;28(2):312-7.
Chia, S. E., Huijun, Z., Theng, T. M., & Yap, E. (2007). Possibilities of newer ALAD polymorphism influencing human susceptibility to effects of inorganic lead on the neurobehavioral functions. Neurotoxicology, 28(2), 312-7.
Chia SE, et al. Possibilities of Newer ALAD Polymorphism Influencing Human Susceptibility to Effects of Inorganic Lead On the Neurobehavioral Functions. Neurotoxicology. 2007;28(2):312-7. PubMed PMID: 16730797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possibilities of newer ALAD polymorphism influencing human susceptibility to effects of inorganic lead on the neurobehavioral functions. AU - Chia,Sin-Eng, AU - Huijun,Zhou, AU - Theng,Tham Mei, AU - Yap,Eric, Y1 - 2006/04/28/ PY - 2005/10/20/received PY - 2006/03/15/revised PY - 2006/04/14/accepted PY - 2006/5/30/pubmed PY - 2007/8/22/medline PY - 2006/5/30/entrez SP - 312 EP - 7 JF - Neurotoxicology JO - Neurotoxicology VL - 28 IS - 2 N2 - OBJECTIVE: A cross-sectional study was conducted to study the association between some new ALAD polymorphism and susceptibility to effects of inorganic lead on the neurobehavioral functions. METHOD: We recruited 120 healthy male workers with lead exposure in a factory which manufacture lead stabilizer. The ALAD SNPs studied were HpyCH4, HpyIV RFLP in intron 6, Rsa and Msp RFLP in exon 4, Sau3A in intron 12 and Rsa39488 in exon 5. The World Health Organization Neurobehavioral Core Test Battery (WHO-NCTB) and a few other tests were used. General linear model (GLM) was applied to compare outcome scores between subgroups of each ALAD SNP while controlling for possible confounders. RESULTS: The mean age of the workers was 39.7 years (S.D. 10.7), mean exposure duration of 10.2 years (S.D. 7.9) and mean blood lead of 22.1 microg/dl (S.D. 9.4). Among the 6 SNPs studied, Rsa and Rsa39488 appear to be the main candidate SNPs. Workers with Rsa and Rsa39488 ALAD 2-2 genotypes fare significantly better in the Aiming Pursue Test Correct (AC), Groove Peg Board non-preferred hand (GPNP), Groove Peg Board Mean (GPM), San Ana Preferred Hand (SAP), San Ana Both Hands (SAB) and AC, GPNH, GPM, Digit Symbol (DIS) tests; respectively compared to Rsa and Rsa39488 ALAD 1-1/1-2 genotypes adjusted for age, race, exposure duration and blood lead levels. CONCLUSION: The presence of the homozygote Rsa and Rsa39488 ALAD 2-2 seems to offer some protection against the effect of lead on motor dexterity function. While it may appear that newer ALAD polymorphism other than the commonly reported Msp SNP might influence human susceptibility to effects of inorganic lead on the neurobehavioral functions further study involving a larger cohort of workers with Rsa and Rsa39488 ALAD2 allele would be needed to confirm this inference. SN - 0161-813X UR - https://www.unboundmedicine.com/medline/citation/16730797/Possibilities_of_newer_ALAD_polymorphism_influencing_human_susceptibility_to_effects_of_inorganic_lead_on_the_neurobehavioral_functions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(06)00103-3 DB - PRIME DP - Unbound Medicine ER -