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Lipid profile, glucose homeostasis, blood pressure, and obesity-anthropometric markers in macrosomic offspring of nondiabetic mothers.
Diabetes Care. 2006 Jun; 29(6):1197-201.DC

Abstract

OBJECTIVE

The study was to determine whether being the macrosomic offspring of a mother without detected glucose intolerance during pregnancy has an impact on lipid profile, glucose homeostasis, and blood pressure during childhood.

RESEARCH DESIGN AND METHODS

Plasma total, HDL, and LDL cholesterol; triglycerides; apolipoprotein (Apo) A-1, -B, and -E; lipoprotein (a); fasting glucose and insulin; homeostasis model assessment of insulin resistance (HOMA-IR) index; blood pressure; BMI; and detailed anthropometry were evaluated in 85 children aged 3-10 years old, born appropriate for gestational age (AGA; n = 48) and large for gestational age (LGA; n = 37) of healthy mothers.

RESULTS

At the time of the assessment, body weight, height, skinfold thickness, BMI, waist circumference, and blood pressure did not differ between the LGA and AGA groups with the exception of head circumference (P < 0.01). There were no significant differences in plasma total or LDL cholesterol; triglycerides; Apo A-1, -B, or -E; lipoprotein (a); Apo B-to-Apo A-1 ratio; or glucose levels between the groups. The LGA group had significantly higher HDL cholesterol levels (P < 0.01), fasting insulin levels (P < 0.01), and HOMA-IR index (P < 0.01) but lower values of the glucose-to-insulin ratio (P < 0.01) as compared with the AGA group.

CONCLUSIONS

Children born LGA of mothers without confirmed impaired glucose tolerance during pregnancy show higher insulin concentrations than AGAs.

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Authors+Show Affiliations

Evagelidou EN
University Hospital of Ioannina, P.O. Box 1186, Ioannina 451 10, Greece.
Kiortsis DN
No affiliation info available
Bairaktari ET
No affiliation info available
Giapros VI
No affiliation info available
Cholevas VK
No affiliation info available
Tzallas CS
No affiliation info available
Andronikou SK
No affiliation info available

MeSH

AdultBirth WeightBlood GlucoseBlood PressureBody HeightBody SizeBody WeightChild, PreschoolFemaleFetal MacrosomiaGestational AgeHumansInfantLipidsMaternal AgeObesitySkinfold Thickness

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16731995

Citation

Evagelidou, Eleni N., et al. "Lipid Profile, Glucose Homeostasis, Blood Pressure, and Obesity-anthropometric Markers in Macrosomic Offspring of Nondiabetic Mothers." Diabetes Care, vol. 29, no. 6, 2006, pp. 1197-201.
Evagelidou EN, Kiortsis DN, Bairaktari ET, et al. Lipid profile, glucose homeostasis, blood pressure, and obesity-anthropometric markers in macrosomic offspring of nondiabetic mothers. Diabetes Care. 2006;29(6):1197-201.
Evagelidou, E. N., Kiortsis, D. N., Bairaktari, E. T., Giapros, V. I., Cholevas, V. K., Tzallas, C. S., & Andronikou, S. K. (2006). Lipid profile, glucose homeostasis, blood pressure, and obesity-anthropometric markers in macrosomic offspring of nondiabetic mothers. Diabetes Care, 29(6), 1197-201.
Evagelidou EN, et al. Lipid Profile, Glucose Homeostasis, Blood Pressure, and Obesity-anthropometric Markers in Macrosomic Offspring of Nondiabetic Mothers. Diabetes Care. 2006;29(6):1197-201. PubMed PMID: 16731995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid profile, glucose homeostasis, blood pressure, and obesity-anthropometric markers in macrosomic offspring of nondiabetic mothers. AU - Evagelidou,Eleni N, AU - Kiortsis,Dimitrios N, AU - Bairaktari,Eleni T, AU - Giapros,Vasileios I, AU - Cholevas,Vasileios K, AU - Tzallas,Christos S, AU - Andronikou,Styliani K, PY - 2006/5/30/pubmed PY - 2006/10/25/medline PY - 2006/5/30/entrez SP - 1197 EP - 201 JF - Diabetes care JO - Diabetes Care VL - 29 IS - 6 N2 - OBJECTIVE: The study was to determine whether being the macrosomic offspring of a mother without detected glucose intolerance during pregnancy has an impact on lipid profile, glucose homeostasis, and blood pressure during childhood. RESEARCH DESIGN AND METHODS: Plasma total, HDL, and LDL cholesterol; triglycerides; apolipoprotein (Apo) A-1, -B, and -E; lipoprotein (a); fasting glucose and insulin; homeostasis model assessment of insulin resistance (HOMA-IR) index; blood pressure; BMI; and detailed anthropometry were evaluated in 85 children aged 3-10 years old, born appropriate for gestational age (AGA; n = 48) and large for gestational age (LGA; n = 37) of healthy mothers. RESULTS: At the time of the assessment, body weight, height, skinfold thickness, BMI, waist circumference, and blood pressure did not differ between the LGA and AGA groups with the exception of head circumference (P < 0.01). There were no significant differences in plasma total or LDL cholesterol; triglycerides; Apo A-1, -B, or -E; lipoprotein (a); Apo B-to-Apo A-1 ratio; or glucose levels between the groups. The LGA group had significantly higher HDL cholesterol levels (P < 0.01), fasting insulin levels (P < 0.01), and HOMA-IR index (P < 0.01) but lower values of the glucose-to-insulin ratio (P < 0.01) as compared with the AGA group. CONCLUSIONS: Children born LGA of mothers without confirmed impaired glucose tolerance during pregnancy show higher insulin concentrations than AGAs. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/16731995/Lipid_profile_glucose_homeostasis_blood_pressure_and_obesity_anthropometric_markers_in_macrosomic_offspring_of_nondiabetic_mothers_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=16731995 DB - PRIME DP - Unbound Medicine ER -