[Biochemical markers of bone turnover in children with celiac disease on gluten-free diet].Med Wieku Rozwoj 2005 Oct-Dec; 9(4):675-83MW
Celiac disease is known to predispose patients to disturbances in bone metabolism. However, little information is available on the biochemical bone turnover markers in celiac children treated with gluten-free diet.
The aim of presented study was to assess bone resorption and formation processes by biochemical bone turnover markers in children with celiac disease on gluten-free diet.
SUBJECTS AND METHODS
We studied 20 children with celiac disease (age range 1.5 - 16 yr; 11 girls, 9 boys). The mean age of diagnosis was 2.6 +/- 1.9 yr and the mean duration of gluten-free diet was 7.8 +/-5.1 yr. Results were compared with those obtained in 130 healthy children. Serum levels of bone-specific alkaline phosphatase and osteocalcin as bone formation indices and serum level of C-telopeptide of type I collagen as bone resorption index were measured by immunoenzymatic methods. Additionally, serum vitamin D, calcium and phosphorus were also estimated.
Lower median values of C-telopeptide of type I collagen were observed in about 50% tested celiac patients. Some of them also had lower osteocalcin level. However, in most patients ranges of values of bone turnover markers were similar to those in the controls. During our observation, all tested children had normal serum concentration of vitamin D as well as of calcium and phosphorus.
Our data show normal bone resorption and formation processes in most patients with celiac disease on gluten-free diet. However, some cases had changes in the pattern of bone turnover markers. Further studies of these patients are needed to assess their predisposition to osteopenia and osteoporosis.