Tags

Type your tag names separated by a space and hit enter

[Dynamic changes of T lymphocyte subsets in the long-term follow-up of severe acute respiratory syndrome patients].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Apr; 28(2):253-5.ZY

Abstract

OBJECTIVE

To study the dynamic changes of T lymphocyte subsets in severe acute respiratory syndrome (SARS) patients.

METHODS

Sequential anti-coagulated blood samples were collected from 62 seropositive SARS patients during the first week, the second week, the first month, the 2nd-3rd month, and 1 year after disease onset. T-lymphocyte subsets including CD4 + T cells, CD8 + T cells, and naive and memory CD4 + T cells were detected by flow cytometry. Samples from 56 healthy blood donors were also detected as healthy controls.

RESULTS

A rapid restoration in T-lymphocyte subsets was observed during a short period after infection. During the 2-3 months after disease onset, CD8 + T cell count returned to the normal level. At the same time point, CD4 + T cell and naive CD4 + T cell counts increased to (534 +/- 197)/mm3 and (175 +/- 75)/mm3 respectively. Total lymphocytes, T lymphocyte, CD4 + T and naive CD4 + T cell were still significantly lower than the normal levels even one year after disease onset.

CONCLUSION

The periphery T lymphocyte subsets in SARS infection shows transient decrease and then rapid recovery.

Authors+Show Affiliations

Department of Infectious Diseases, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16733915

Citation

Xie, Jing, et al. "[Dynamic Changes of T Lymphocyte Subsets in the Long-term Follow-up of Severe Acute Respiratory Syndrome Patients]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 28, no. 2, 2006, pp. 253-5.
Xie J, Fan HW, Li TS, et al. [Dynamic changes of T lymphocyte subsets in the long-term follow-up of severe acute respiratory syndrome patients]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006;28(2):253-5.
Xie, J., Fan, H. W., Li, T. S., Qiu, Z. F., & Han, Y. (2006). [Dynamic changes of T lymphocyte subsets in the long-term follow-up of severe acute respiratory syndrome patients]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 28(2), 253-5.
Xie J, et al. [Dynamic Changes of T Lymphocyte Subsets in the Long-term Follow-up of Severe Acute Respiratory Syndrome Patients]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006;28(2):253-5. PubMed PMID: 16733915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dynamic changes of T lymphocyte subsets in the long-term follow-up of severe acute respiratory syndrome patients]. AU - Xie,Jing, AU - Fan,Hong-wei, AU - Li,Tai-sheng, AU - Qiu,Zhi-feng, AU - Han,Yang, PY - 2006/6/1/pubmed PY - 2006/7/22/medline PY - 2006/6/1/entrez SP - 253 EP - 5 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 28 IS - 2 N2 - OBJECTIVE: To study the dynamic changes of T lymphocyte subsets in severe acute respiratory syndrome (SARS) patients. METHODS: Sequential anti-coagulated blood samples were collected from 62 seropositive SARS patients during the first week, the second week, the first month, the 2nd-3rd month, and 1 year after disease onset. T-lymphocyte subsets including CD4 + T cells, CD8 + T cells, and naive and memory CD4 + T cells were detected by flow cytometry. Samples from 56 healthy blood donors were also detected as healthy controls. RESULTS: A rapid restoration in T-lymphocyte subsets was observed during a short period after infection. During the 2-3 months after disease onset, CD8 + T cell count returned to the normal level. At the same time point, CD4 + T cell and naive CD4 + T cell counts increased to (534 +/- 197)/mm3 and (175 +/- 75)/mm3 respectively. Total lymphocytes, T lymphocyte, CD4 + T and naive CD4 + T cell were still significantly lower than the normal levels even one year after disease onset. CONCLUSION: The periphery T lymphocyte subsets in SARS infection shows transient decrease and then rapid recovery. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/16733915/[Dynamic_changes_of_T_lymphocyte_subsets_in_the_long_term_follow_up_of_severe_acute_respiratory_syndrome_patients]_ L2 - https://antibodies.cancer.gov/detail/CPTC-CD4-1 DB - PRIME DP - Unbound Medicine ER -