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[Advances in researches on genetic epidemiology of pancreatic cancer].

Abstract

Pancreatic cancer is an extremely life-threatening neoplasm with a case-fatality rate approaching 100%. Smoking is the major known risk factor for this cancer, explaining 19% of all cases. The nutrition and food consumption patterns play other important roles in the etiology of pancreatic cancer, explaining 35% of all cases. Epidemiological evidences on the relationship between nutrition and pancreatic cancer found consistently positive associations between the intakes of meat, carbohydrates, and dietary cholesterol and pancreatic cancer. Consistent inverse relationships with fruit and vegetable intakes and, in particular, with fiber and vitamin C, have also been noted. Many inherited germline mutations increase the risk of pancreatic cancer. In addition, several common polymorphisms in genes that associated with metabolism of environmental carcinogens, DNA repair and folate metabolism may alter the risk of pancreatic cancer. Interaction between genes and environmental factors may contribute to the risk of pancreatic cancer.

Authors+Show Affiliations

Department of Epidemiology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

chi

PubMed ID

16733922

Citation

Wang, Li, and Hui Li. "[Advances in Researches On Genetic Epidemiology of Pancreatic Cancer]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 28, no. 2, 2006, pp. 289-93.
Wang L, Li H. [Advances in researches on genetic epidemiology of pancreatic cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006;28(2):289-93.
Wang, L., & Li, H. (2006). [Advances in researches on genetic epidemiology of pancreatic cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 28(2), pp. 289-93.
Wang L, Li H. [Advances in Researches On Genetic Epidemiology of Pancreatic Cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006;28(2):289-93. PubMed PMID: 16733922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Advances in researches on genetic epidemiology of pancreatic cancer]. AU - Wang,Li, AU - Li,Hui, PY - 2006/6/1/pubmed PY - 2006/7/22/medline PY - 2006/6/1/entrez SP - 289 EP - 93 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 28 IS - 2 N2 - Pancreatic cancer is an extremely life-threatening neoplasm with a case-fatality rate approaching 100%. Smoking is the major known risk factor for this cancer, explaining 19% of all cases. The nutrition and food consumption patterns play other important roles in the etiology of pancreatic cancer, explaining 35% of all cases. Epidemiological evidences on the relationship between nutrition and pancreatic cancer found consistently positive associations between the intakes of meat, carbohydrates, and dietary cholesterol and pancreatic cancer. Consistent inverse relationships with fruit and vegetable intakes and, in particular, with fiber and vitamin C, have also been noted. Many inherited germline mutations increase the risk of pancreatic cancer. In addition, several common polymorphisms in genes that associated with metabolism of environmental carcinogens, DNA repair and folate metabolism may alter the risk of pancreatic cancer. Interaction between genes and environmental factors may contribute to the risk of pancreatic cancer. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/16733922/[Advances_in_researches_on_genetic_epidemiology_of_pancreatic_cancer]_ L2 - http://www.actacams.com/article/2006/1000-503X/1000-503X-28-2-289.pdf DB - PRIME DP - Unbound Medicine ER -