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Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study.
J Bone Miner Res. 2006 May; 21(5):790-5.JB

Abstract

The importance of pubertal timing for adult BMD in males was studied through association of pubertal timing with young adult bone phenotype. Pubertal timing was found to predict both cortical and trabecular volumetric BMD and previous fractures in young adult men. Thus, late puberty is a risk factor for low BMD and previous fractures in young adult men.

INTRODUCTION

Peak bone mass (PBM), achieved during puberty, is a determinant of the risk for osteoporosis and future fractures. The role of variations within the normal range in pubertal timing for fractures during pubertal development and for adult bone mass in men is unknown.

MATERIALS AND METHODS

The aim of this study was to investigate the importance of pubertal timing for adult BMD and for fractures before achievement of PBM in men. The population-based Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a well-characterized cohort of young adult Swedish males 18-20 years of age. Detailed growth charts from birth to 18-20 years of age were retrieved for 642 men participating in the GOOD study. Age at peak height velocity (PHV) was estimated and used as an assessment of pubertal timing. The skeletal phenotype was analyzed at young adult age using DXA and pQCT and previous fractures were assessed by questionnaires.

RESULTS

Age at PHV was a negative independent predictor of both adult cortical and trabecular volumetric BMD and of total body and radius areal BMD. Moreover, age at PHV was associated with previous fractures in a logistic regression analysis. The OR for cortical osteopenia was 2.49 (95% CI, 1.91-3.24; p < 0.001) and for previous upper limb fractures was 1.35 (95% CI, 1.04-1.75; p < 0.05) per year increment in age at PHV.

CONCLUSIONS

Age at PHV is a negative independent predictor of BMD and a positive predictor of previous fractures in young adult men. Longitudinal studies to determine if pubertal timing also predicts BMD and fractures in elderly men are required.

Authors+Show Affiliations

Bone Research Center, Department of Medicine, The Sahlgrenska Academy at Gothenburg University, Sweden. jenny.kindblom@medic.gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16734395

Citation

Kindblom, Jenny M., et al. "Pubertal Timing Predicts Previous Fractures and BMD in Young Adult Men: the GOOD Study." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 21, no. 5, 2006, pp. 790-5.
Kindblom JM, Lorentzon M, Norjavaara E, et al. Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study. J Bone Miner Res. 2006;21(5):790-5.
Kindblom, J. M., Lorentzon, M., Norjavaara, E., Hellqvist, A., Nilsson, S., Mellström, D., & Ohlsson, C. (2006). Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 21(5), 790-5.
Kindblom JM, et al. Pubertal Timing Predicts Previous Fractures and BMD in Young Adult Men: the GOOD Study. J Bone Miner Res. 2006;21(5):790-5. PubMed PMID: 16734395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study. AU - Kindblom,Jenny M, AU - Lorentzon,Mattias, AU - Norjavaara,Ensio, AU - Hellqvist,Asa, AU - Nilsson,Staffan, AU - Mellström,Dan, AU - Ohlsson,Claes, PY - 2006/6/1/pubmed PY - 2006/10/4/medline PY - 2006/6/1/entrez SP - 790 EP - 5 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 21 IS - 5 N2 - UNLABELLED: The importance of pubertal timing for adult BMD in males was studied through association of pubertal timing with young adult bone phenotype. Pubertal timing was found to predict both cortical and trabecular volumetric BMD and previous fractures in young adult men. Thus, late puberty is a risk factor for low BMD and previous fractures in young adult men. INTRODUCTION: Peak bone mass (PBM), achieved during puberty, is a determinant of the risk for osteoporosis and future fractures. The role of variations within the normal range in pubertal timing for fractures during pubertal development and for adult bone mass in men is unknown. MATERIALS AND METHODS: The aim of this study was to investigate the importance of pubertal timing for adult BMD and for fractures before achievement of PBM in men. The population-based Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a well-characterized cohort of young adult Swedish males 18-20 years of age. Detailed growth charts from birth to 18-20 years of age were retrieved for 642 men participating in the GOOD study. Age at peak height velocity (PHV) was estimated and used as an assessment of pubertal timing. The skeletal phenotype was analyzed at young adult age using DXA and pQCT and previous fractures were assessed by questionnaires. RESULTS: Age at PHV was a negative independent predictor of both adult cortical and trabecular volumetric BMD and of total body and radius areal BMD. Moreover, age at PHV was associated with previous fractures in a logistic regression analysis. The OR for cortical osteopenia was 2.49 (95% CI, 1.91-3.24; p < 0.001) and for previous upper limb fractures was 1.35 (95% CI, 1.04-1.75; p < 0.05) per year increment in age at PHV. CONCLUSIONS: Age at PHV is a negative independent predictor of BMD and a positive predictor of previous fractures in young adult men. Longitudinal studies to determine if pubertal timing also predicts BMD and fractures in elderly men are required. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/16734395/Pubertal_timing_predicts_previous_fractures_and_BMD_in_young_adult_men:_the_GOOD_study_ L2 - https://doi.org/10.1359/jbmr.020602 DB - PRIME DP - Unbound Medicine ER -