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Human African trypanosomiasis: Epidemiology and control.
Adv Parasitol. 2006; 61:167-221.AP

Abstract

Human African trypanosomiasis (HAT), or sleeping sickness, describes not one but two discrete diseases: that caused by Trypanosoma brucei rhodesiense and that caused by T. b. gambiense. The Gambian form is currently a major public health problem over vast areas of central and western Africa, while the zoonotic, Rhodesian form continues to present a serious health risk in eastern and southern Africa. The two parasites cause distinct clinical manifestations, and there are significant differences in the epidemiology of the diseases caused. We discuss the differences between the diseases caused by the two parasites, with an emphasis on disease burden, reservoir hosts, transmission, diagnosis, treatment and control. We analyse how these differences impacted on historical disease control trends and how they can inform contemporary treatment and control options. We consider the optimal ways in which to devise HAT control policies in light of the differing biology and epidemiology of the parasites, and emphasise, in particular, the wider aspects of control policy, outlining the responsibilities of individuals, governments and international organisations in control programmes.

Authors+Show Affiliations

Centre for Infectious Diseases, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian, EH25 9RG, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16735165

Citation

Fèvre, E M., et al. "Human African Trypanosomiasis: Epidemiology and Control." Advances in Parasitology, vol. 61, 2006, pp. 167-221.
Fèvre EM, Picozzi K, Jannin J, et al. Human African trypanosomiasis: Epidemiology and control. Adv Parasitol. 2006;61:167-221.
Fèvre, E. M., Picozzi, K., Jannin, J., Welburn, S. C., & Maudlin, I. (2006). Human African trypanosomiasis: Epidemiology and control. Advances in Parasitology, 61, 167-221.
Fèvre EM, et al. Human African Trypanosomiasis: Epidemiology and Control. Adv Parasitol. 2006;61:167-221. PubMed PMID: 16735165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human African trypanosomiasis: Epidemiology and control. AU - Fèvre,E M, AU - Picozzi,K, AU - Jannin,J, AU - Welburn,S C, AU - Maudlin,I, PY - 2006/6/1/pubmed PY - 2006/10/20/medline PY - 2006/6/1/entrez SP - 167 EP - 221 JF - Advances in parasitology JO - Adv Parasitol VL - 61 N2 - Human African trypanosomiasis (HAT), or sleeping sickness, describes not one but two discrete diseases: that caused by Trypanosoma brucei rhodesiense and that caused by T. b. gambiense. The Gambian form is currently a major public health problem over vast areas of central and western Africa, while the zoonotic, Rhodesian form continues to present a serious health risk in eastern and southern Africa. The two parasites cause distinct clinical manifestations, and there are significant differences in the epidemiology of the diseases caused. We discuss the differences between the diseases caused by the two parasites, with an emphasis on disease burden, reservoir hosts, transmission, diagnosis, treatment and control. We analyse how these differences impacted on historical disease control trends and how they can inform contemporary treatment and control options. We consider the optimal ways in which to devise HAT control policies in light of the differing biology and epidemiology of the parasites, and emphasise, in particular, the wider aspects of control policy, outlining the responsibilities of individuals, governments and international organisations in control programmes. SN - 0065-308X UR - https://www.unboundmedicine.com/medline/citation/16735165/Human_African_trypanosomiasis:_Epidemiology_and_control_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0065-308X(05)61005-6 DB - PRIME DP - Unbound Medicine ER -