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How can osteoporosis patients benefit more from their therapy? Adherence issues with bisphosphonate therapy.
Ann Pharmacother. 2006 Jun; 40(6):1143-50.AP

Abstract

OBJECTIVE

To review the evidence on adherence with bisphosphonates and evolving dosing strategies for osteoporosis treatment.

DATA SOURCES

Articles were identified by searching MEDLINE (1975-December 2005) using the following terms: osteoporosis, postmenopausal, fracture, adherence, compliance, persistence, drug therapy, bisphosphonates, alendronate, risedronate, ibandronate, and zoledronate. Additional data included bibliographies from identified articles.

STUDY SELECTION AND DATA EXTRACTION

All pertinent English-language articles that discussed adherence issues in patients with osteoporosis were included. Both those that reviewed overall issues of medication adherence in osteoporosis and those that focused specifically on adherence to bisphosphonates were included, as were articles that addressed strategies for overcoming nonadherence.

DATA SYNTHESIS

Inadequate diagnosis and treatment of osteoporosis result in a higher risk of fractures than is necessary. Even patients who are diagnosed and beginning treatment often do not persist with their osteoporosis medication because they perceive their fracture risk to be low and, given the asymptomatic nature of osteoporosis, do not experience the benefit of symptom reduction after taking the drugs. Factors that affect adherence to osteoporosis therapy include drug costs, adverse effects, dosing frequency, disease education, patient follow-up, and patient involvement in treatment decisions.

CONCLUSIONS

By considering and implementing strategies that can improve adherence and persistence, primary care providers and pharmacists (via counseling) may enhance long-term outcomes for patients with osteoporosis.

Authors+Show Affiliations

Gold DT
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Alexander IM
No affiliation info available
Ettinger MP
No affiliation info available

MeSH

AdultBone Density Conservation AgentsDiphosphonatesFemaleHumansInjections, IntravenousMiddle AgedOsteoporosisOsteoporosis, PostmenopausalPatient CompliancePatient Education as Topic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16735667

Citation

Gold, Deborah T., et al. "How Can Osteoporosis Patients Benefit More From Their Therapy? Adherence Issues With Bisphosphonate Therapy." The Annals of Pharmacotherapy, vol. 40, no. 6, 2006, pp. 1143-50.
Gold DT, Alexander IM, Ettinger MP. How can osteoporosis patients benefit more from their therapy? Adherence issues with bisphosphonate therapy. Ann Pharmacother. 2006;40(6):1143-50.
Gold, D. T., Alexander, I. M., & Ettinger, M. P. (2006). How can osteoporosis patients benefit more from their therapy? Adherence issues with bisphosphonate therapy. The Annals of Pharmacotherapy, 40(6), 1143-50.
Gold DT, Alexander IM, Ettinger MP. How Can Osteoporosis Patients Benefit More From Their Therapy? Adherence Issues With Bisphosphonate Therapy. Ann Pharmacother. 2006;40(6):1143-50. PubMed PMID: 16735667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How can osteoporosis patients benefit more from their therapy? Adherence issues with bisphosphonate therapy. AU - Gold,Deborah T, AU - Alexander,Ivy M, AU - Ettinger,Mark P, Y1 - 2006/05/30/ PY - 2006/6/1/pubmed PY - 2006/8/24/medline PY - 2006/6/1/entrez SP - 1143 EP - 50 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 40 IS - 6 N2 - OBJECTIVE: To review the evidence on adherence with bisphosphonates and evolving dosing strategies for osteoporosis treatment. DATA SOURCES: Articles were identified by searching MEDLINE (1975-December 2005) using the following terms: osteoporosis, postmenopausal, fracture, adherence, compliance, persistence, drug therapy, bisphosphonates, alendronate, risedronate, ibandronate, and zoledronate. Additional data included bibliographies from identified articles. STUDY SELECTION AND DATA EXTRACTION: All pertinent English-language articles that discussed adherence issues in patients with osteoporosis were included. Both those that reviewed overall issues of medication adherence in osteoporosis and those that focused specifically on adherence to bisphosphonates were included, as were articles that addressed strategies for overcoming nonadherence. DATA SYNTHESIS: Inadequate diagnosis and treatment of osteoporosis result in a higher risk of fractures than is necessary. Even patients who are diagnosed and beginning treatment often do not persist with their osteoporosis medication because they perceive their fracture risk to be low and, given the asymptomatic nature of osteoporosis, do not experience the benefit of symptom reduction after taking the drugs. Factors that affect adherence to osteoporosis therapy include drug costs, adverse effects, dosing frequency, disease education, patient follow-up, and patient involvement in treatment decisions. CONCLUSIONS: By considering and implementing strategies that can improve adherence and persistence, primary care providers and pharmacists (via counseling) may enhance long-term outcomes for patients with osteoporosis. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/16735667/How_can_osteoporosis_patients_benefit_more_from_their_therapy_Adherence_issues_with_bisphosphonate_therapy_ DB - PRIME DP - Unbound Medicine ER -