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Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age.
Menopause 2006 May-Jun; 13(3):474-81M

Abstract

OBJECTIVE

Few studies have investigated the relationships between body composition, functional ability, and age-related disability in postmenopausal women. We investigated the relative role of fat mass, lean mass, and muscle strength in the development of disability in a group of healthy postmenopausal women younger than 75 years.

DESIGN

We performed a cross-sectional study among 396 independently living women aged 56-73 years, randomly selected between 8 and 30 years after menopause. Lean mass and fat mass were assessed by dual-energy x-ray absorptiometry. Muscle strength (grip and leg extensors) was assessed using dynamometry. Functional ability was estimated by Physical Performance Score, physical activity during the preceding year, and impairment in activities of daily living.

RESULTS

Of the participants, 43.7 % were overweight (25 > or = BMI < 30 kg/m2), and 17.7% were obese (BM I > or = 30 kg/m2). Higher muscle strength was observed with increasing lean body mass, and participants with higher muscle strength scored better in the physical performance score and activities of daily living. Higher fat mass was significantly associated with a lower physical performance score, lower physical activity, and a higher frequency of disability. Increasing fat mass was associated with increasing lean mass and decreasing lean/fat ratio. The increase in lean mass and muscle strength associated with higher fat mass was mainly localized in the legs.

CONCLUSIONS

Our results support the role of fat mass as the primary risk marker for disability, which might later accelerate by the age-related decrease in lean mass and the development of sarcopenia after the age of 75 years.

Authors+Show Affiliations

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16735945

Citation

Lebrun, Corinne E I., et al. "Fat Mass Rather Than Muscle Strength Is the Major Determinant of Physical Function and Disability in Postmenopausal Women Younger Than 75 Years of Age." Menopause (New York, N.Y.), vol. 13, no. 3, 2006, pp. 474-81.
Lebrun CE, van der Schouw YT, de Jong FH, et al. Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age. Menopause. 2006;13(3):474-81.
Lebrun, C. E., van der Schouw, Y. T., de Jong, F. H., Grobbee, D. E., & Lamberts, S. W. (2006). Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age. Menopause (New York, N.Y.), 13(3), pp. 474-81.
Lebrun CE, et al. Fat Mass Rather Than Muscle Strength Is the Major Determinant of Physical Function and Disability in Postmenopausal Women Younger Than 75 Years of Age. Menopause. 2006;13(3):474-81. PubMed PMID: 16735945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age. AU - Lebrun,Corinne E I, AU - van der Schouw,Yvonne T, AU - de Jong,Frank H, AU - Grobbee,Diederick E, AU - Lamberts,Steven W, PY - 2006/6/1/pubmed PY - 2006/8/3/medline PY - 2006/6/1/entrez SP - 474 EP - 81 JF - Menopause (New York, N.Y.) JO - Menopause VL - 13 IS - 3 N2 - OBJECTIVE: Few studies have investigated the relationships between body composition, functional ability, and age-related disability in postmenopausal women. We investigated the relative role of fat mass, lean mass, and muscle strength in the development of disability in a group of healthy postmenopausal women younger than 75 years. DESIGN: We performed a cross-sectional study among 396 independently living women aged 56-73 years, randomly selected between 8 and 30 years after menopause. Lean mass and fat mass were assessed by dual-energy x-ray absorptiometry. Muscle strength (grip and leg extensors) was assessed using dynamometry. Functional ability was estimated by Physical Performance Score, physical activity during the preceding year, and impairment in activities of daily living. RESULTS: Of the participants, 43.7 % were overweight (25 > or = BMI < 30 kg/m2), and 17.7% were obese (BM I > or = 30 kg/m2). Higher muscle strength was observed with increasing lean body mass, and participants with higher muscle strength scored better in the physical performance score and activities of daily living. Higher fat mass was significantly associated with a lower physical performance score, lower physical activity, and a higher frequency of disability. Increasing fat mass was associated with increasing lean mass and decreasing lean/fat ratio. The increase in lean mass and muscle strength associated with higher fat mass was mainly localized in the legs. CONCLUSIONS: Our results support the role of fat mass as the primary risk marker for disability, which might later accelerate by the age-related decrease in lean mass and the development of sarcopenia after the age of 75 years. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/16735945/Fat_mass_rather_than_muscle_strength_is_the_major_determinant_of_physical_function_and_disability_in_postmenopausal_women_younger_than_75_years_of_age_ L2 - http://Insights.ovid.com/pubmed?pmid=16735945 DB - PRIME DP - Unbound Medicine ER -