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Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula.
Eur J Clin Nutr 2006; 60(11):1304-10EJ

Abstract

OBJECTIVES

The aim of this study was to evaluate the efficacy on crying episodes owing to infantile colic of a new infant formula containing partially hydrolysed whey proteins, prebiotic oligosaccharides (OS), with a high beta-palmitic acid content.

DESIGN

Prospective randomized controlled study.

SETTING

Italy.

SUBJECTS

Two hundred and sixty-seven formula-fed infants, aged less than 4 months, with infantile colic, were randomized to receive either the new infant formula (study treatment (ST)) or a standard formula and simethicone (6 mg/kg twice a day) (control treatment (CT)). A questionnaire was given to parents to evaluate for 14 days the daily number of colic episodes and crying time.

RESULTS

Out of the 199 infants who completed the study, 96 were treated with the new formula and 103 were not treated. Infants receiving the new formula had a significant decrease in colic episodes after 1 week (2.47+/-1.94 at day 7 vs 5.99+/-1.84 at the study entry) compared to infants receiving the CT (3.72+/-1.98 at day 7 vs 5.41+/-1.88 at the study entry) (P < 0.0001). Also at day 14, the crying episodes were significantly different between the two groups of infants (1.76+/-1.60 in ST vs 3.32+/-2.06 in CT) (P < 0.0001).

CONCLUSIONS

The use of a partially hydrolysed formula supplemented with fructo- and galacto-OS induces a reduction of crying episodes in infants with colic after 7 and 14 days when compared with a standard formula and simethicone.

Authors+Show Affiliations

Department of Paediatrics, University of Turin, Turin, Italy. francesco.savino@unito.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16736065

Citation

Savino, F, et al. "Reduction of Crying Episodes Owing to Infantile Colic: a Randomized Controlled Study On the Efficacy of a New Infant Formula." European Journal of Clinical Nutrition, vol. 60, no. 11, 2006, pp. 1304-10.
Savino F, Palumeri E, Castagno E, et al. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr. 2006;60(11):1304-10.
Savino, F., Palumeri, E., Castagno, E., Cresi, F., Dalmasso, P., Cavallo, F., & Oggero, R. (2006). Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. European Journal of Clinical Nutrition, 60(11), pp. 1304-10.
Savino F, et al. Reduction of Crying Episodes Owing to Infantile Colic: a Randomized Controlled Study On the Efficacy of a New Infant Formula. Eur J Clin Nutr. 2006;60(11):1304-10. PubMed PMID: 16736065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. AU - Savino,F, AU - Palumeri,E, AU - Castagno,E, AU - Cresi,F, AU - Dalmasso,P, AU - Cavallo,F, AU - Oggero,R, Y1 - 2006/05/31/ PY - 2006/6/1/pubmed PY - 2007/1/24/medline PY - 2006/6/1/entrez SP - 1304 EP - 10 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 11 N2 - OBJECTIVES: The aim of this study was to evaluate the efficacy on crying episodes owing to infantile colic of a new infant formula containing partially hydrolysed whey proteins, prebiotic oligosaccharides (OS), with a high beta-palmitic acid content. DESIGN: Prospective randomized controlled study. SETTING: Italy. SUBJECTS: Two hundred and sixty-seven formula-fed infants, aged less than 4 months, with infantile colic, were randomized to receive either the new infant formula (study treatment (ST)) or a standard formula and simethicone (6 mg/kg twice a day) (control treatment (CT)). A questionnaire was given to parents to evaluate for 14 days the daily number of colic episodes and crying time. RESULTS: Out of the 199 infants who completed the study, 96 were treated with the new formula and 103 were not treated. Infants receiving the new formula had a significant decrease in colic episodes after 1 week (2.47+/-1.94 at day 7 vs 5.99+/-1.84 at the study entry) compared to infants receiving the CT (3.72+/-1.98 at day 7 vs 5.41+/-1.88 at the study entry) (P < 0.0001). Also at day 14, the crying episodes were significantly different between the two groups of infants (1.76+/-1.60 in ST vs 3.32+/-2.06 in CT) (P < 0.0001). CONCLUSIONS: The use of a partially hydrolysed formula supplemented with fructo- and galacto-OS induces a reduction of crying episodes in infants with colic after 7 and 14 days when compared with a standard formula and simethicone. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16736065/Reduction_of_crying_episodes_owing_to_infantile_colic:_A_randomized_controlled_study_on_the_efficacy_of_a_new_infant_formula_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602457 DB - PRIME DP - Unbound Medicine ER -