Tags

Type your tag names separated by a space and hit enter

Moderate prenatal alcohol exposure and cognitive status of children at age 10.
Alcohol Clin Exp Res. 2006 Jun; 30(6):1051-9.AC

Abstract

BACKGROUND

The effects of prenatal alcohol exposure (PAE) on measures of intelligence have been well documented in children with fetal alcohol syndrome. However, deficits in general intellectual ability in children with low to moderate PAE are less well understood. The objective of this study was to assess the association between moderate PAE and cognitive ability in children at age 10 controlling for other prenatal and birth factors, maternal and child psychosocial factors, and environmental characteristics.

METHODS

Data were collected as part of the Maternal Health Practices and Child Development Project, a prospective study of prenatal substance use with 636 mother-child pairs. Women were assessed during each trimester of pregnancy and with their children at birth; 8 and 18 months; and 3, 6, and 10 years. Each phase included an evaluation of growth, development, cognitive, and psychological functioning. At age 10, cognitive ability was assessed using the composite score and verbal, abstract/visual, quantitative, and short-term memory area scores of the Stanford-Binet Intelligence Test, fourth edition. Maternal intellectual ability, maternal prenatal and current drug use, maternal and child psychosocial characteristics, demographics, and home environment were included in the analysis.

RESULTS

A significant relation was found between alcohol exposure during the first and second trimesters and the composite score of the Stanford-Binet for African American children at age 10. Significant relations were also found for the verbal, abstract/visual, and quantitative subscales. Additional predictors of IQ at age 10 included mother's IQ, home environment, and child's report of depression.

CONCLUSIONS

There is a significant association between PAE and cognitive ability at age 10 among African American offspring. There was no relation between PAE and scores on the Stanford-Binet scales among the Caucasian offspring.

Authors+Show Affiliations

Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA. willford@epid.wpic.pitt.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16737465

Citation

Willford, Jennifera, et al. "Moderate Prenatal Alcohol Exposure and Cognitive Status of Children at Age 10." Alcoholism, Clinical and Experimental Research, vol. 30, no. 6, 2006, pp. 1051-9.
Willford J, Leech S, Day N. Moderate prenatal alcohol exposure and cognitive status of children at age 10. Alcohol Clin Exp Res. 2006;30(6):1051-9.
Willford, J., Leech, S., & Day, N. (2006). Moderate prenatal alcohol exposure and cognitive status of children at age 10. Alcoholism, Clinical and Experimental Research, 30(6), 1051-9.
Willford J, Leech S, Day N. Moderate Prenatal Alcohol Exposure and Cognitive Status of Children at Age 10. Alcohol Clin Exp Res. 2006;30(6):1051-9. PubMed PMID: 16737465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate prenatal alcohol exposure and cognitive status of children at age 10. AU - Willford,Jennifera, AU - Leech,Sharonl, AU - Day,Nancyl, PY - 2006/6/2/pubmed PY - 2006/9/6/medline PY - 2006/6/2/entrez SP - 1051 EP - 9 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 30 IS - 6 N2 - BACKGROUND: The effects of prenatal alcohol exposure (PAE) on measures of intelligence have been well documented in children with fetal alcohol syndrome. However, deficits in general intellectual ability in children with low to moderate PAE are less well understood. The objective of this study was to assess the association between moderate PAE and cognitive ability in children at age 10 controlling for other prenatal and birth factors, maternal and child psychosocial factors, and environmental characteristics. METHODS: Data were collected as part of the Maternal Health Practices and Child Development Project, a prospective study of prenatal substance use with 636 mother-child pairs. Women were assessed during each trimester of pregnancy and with their children at birth; 8 and 18 months; and 3, 6, and 10 years. Each phase included an evaluation of growth, development, cognitive, and psychological functioning. At age 10, cognitive ability was assessed using the composite score and verbal, abstract/visual, quantitative, and short-term memory area scores of the Stanford-Binet Intelligence Test, fourth edition. Maternal intellectual ability, maternal prenatal and current drug use, maternal and child psychosocial characteristics, demographics, and home environment were included in the analysis. RESULTS: A significant relation was found between alcohol exposure during the first and second trimesters and the composite score of the Stanford-Binet for African American children at age 10. Significant relations were also found for the verbal, abstract/visual, and quantitative subscales. Additional predictors of IQ at age 10 included mother's IQ, home environment, and child's report of depression. CONCLUSIONS: There is a significant association between PAE and cognitive ability at age 10 among African American offspring. There was no relation between PAE and scores on the Stanford-Binet scales among the Caucasian offspring. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/16737465/Moderate_prenatal_alcohol_exposure_and_cognitive_status_of_children_at_age_10_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2006&volume=30&issue=6&spage=1051 DB - PRIME DP - Unbound Medicine ER -