Tags

Type your tag names separated by a space and hit enter

Prolonged protection against methacholine-induced bronchoconstriction by the inhaled beta 2-agonist formoterol.
Am Rev Respir Dis. 1991 May; 143(5 Pt 1):998-1001.AR

Abstract

Formoterol fumarate is a new, high-affinity, beta 2-adrenergic receptor agonist that causes bronchodilation for at least 12 h. The purpose of this study was to compare the magnitude and duration of the effect of inhalation of formoterol (12 and 24 micrograms), albuterol (200 micrograms), and placebo in terms of protection against methacholine-induced bronchoconstriction. The 16 stable adult asthmatic subjects were studied on four separate study days. On each study day the subjects inhaled 2 puffs of the study medication, and methacholine tests were performed at 30 min and 4, 8, and 12 h later. Results were expressed as the provocative concentration of methacholine required to cause a 20% fall in FEV1 (PC20). At 30 min, 12 and 24 micrograms formoterol caused a mean 14- to 20-fold decrease in responsiveness, and albuterol a 12-fold decrease. However, albuterol had no significant protective effect at 4 h or thereafter, whereas there was still an 8-fold decrease in responsiveness for 24 micrograms formoterol and a 6-fold decrease for 12 micrograms formoterol at 12 h. This study has shown that both doses of formoterol were still actively protective against induced bronchoconstriction 12 h after inhalation, with minimal side effects. This suggests that formoterol may prove to be a very useful bronchodilator for the treatment of patients with asthma who have significant airway hyperresponsiveness or nocturnal symptoms and who require inhaled beta 2-agonists at least twice daily.

Authors+Show Affiliations

Department of Medicine, St. Joseph's Hospital, Hamilton, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1673830

Citation

Ramsdale, E H., et al. "Prolonged Protection Against Methacholine-induced Bronchoconstriction By the Inhaled Beta 2-agonist Formoterol." The American Review of Respiratory Disease, vol. 143, no. 5 Pt 1, 1991, pp. 998-1001.
Ramsdale EH, Otis J, Kline PA, et al. Prolonged protection against methacholine-induced bronchoconstriction by the inhaled beta 2-agonist formoterol. Am Rev Respir Dis. 1991;143(5 Pt 1):998-1001.
Ramsdale, E. H., Otis, J., Kline, P. A., Gontovnick, L. S., Hargreave, F. E., & O'Byrne, P. M. (1991). Prolonged protection against methacholine-induced bronchoconstriction by the inhaled beta 2-agonist formoterol. The American Review of Respiratory Disease, 143(5 Pt 1), 998-1001.
Ramsdale EH, et al. Prolonged Protection Against Methacholine-induced Bronchoconstriction By the Inhaled Beta 2-agonist Formoterol. Am Rev Respir Dis. 1991;143(5 Pt 1):998-1001. PubMed PMID: 1673830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged protection against methacholine-induced bronchoconstriction by the inhaled beta 2-agonist formoterol. AU - Ramsdale,E H, AU - Otis,J, AU - Kline,P A, AU - Gontovnick,L S, AU - Hargreave,F E, AU - O'Byrne,P M, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 998 EP - 1001 JF - The American review of respiratory disease JO - Am. Rev. Respir. Dis. VL - 143 IS - 5 Pt 1 N2 - Formoterol fumarate is a new, high-affinity, beta 2-adrenergic receptor agonist that causes bronchodilation for at least 12 h. The purpose of this study was to compare the magnitude and duration of the effect of inhalation of formoterol (12 and 24 micrograms), albuterol (200 micrograms), and placebo in terms of protection against methacholine-induced bronchoconstriction. The 16 stable adult asthmatic subjects were studied on four separate study days. On each study day the subjects inhaled 2 puffs of the study medication, and methacholine tests were performed at 30 min and 4, 8, and 12 h later. Results were expressed as the provocative concentration of methacholine required to cause a 20% fall in FEV1 (PC20). At 30 min, 12 and 24 micrograms formoterol caused a mean 14- to 20-fold decrease in responsiveness, and albuterol a 12-fold decrease. However, albuterol had no significant protective effect at 4 h or thereafter, whereas there was still an 8-fold decrease in responsiveness for 24 micrograms formoterol and a 6-fold decrease for 12 micrograms formoterol at 12 h. This study has shown that both doses of formoterol were still actively protective against induced bronchoconstriction 12 h after inhalation, with minimal side effects. This suggests that formoterol may prove to be a very useful bronchodilator for the treatment of patients with asthma who have significant airway hyperresponsiveness or nocturnal symptoms and who require inhaled beta 2-agonists at least twice daily. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/1673830/Prolonged_protection_against_methacholine_induced_bronchoconstriction_by_the_inhaled_beta_2_agonist_formoterol_ L2 - http://www.atsjournals.org/doi/full/10.1164/ajrccm/143.5_Pt_1.998?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -