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The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5'-monophosphate and histamine in asthma.
J Allergy Clin Immunol. 1991 May; 87(5):939-47.JA

Abstract

The aim of this study was to investigate the effect of terfenadine, an antihistamine, 180 mg orally, the anticholinergic drug, ipratropium bromide (IB), 0.5 mg nebulized aerosol, the combination of these two drugs, and placebo tablets and aerosol on histamine- and adenosine 5'-monophosphate (AMP)-induced bronchoconstriction in a randomized, double-blind fashion. Airway response was evaluated as FEV1. After placebo, the geometric mean (GM) provocative concentration causing a 20% in FEV1 from the postsaline baseline value (PC20) for histamine and AMP was 0.63 and 5 mg/ml, respectively. Terfenadine displaced the FEV1 concentration-response curves obtained with both histamine (GM PC20 values increasing to 26.92 mg/ml) and AMP (GM PC20 values increasing to 26.7 mg/ml) to the right. IB had a small, but significant, protective effect against the fall in FEV1 produced by histamine and AMP, the GM PC20 values increasing to 1.69 and to 12.6 mg/ml, respectively. Terfenadine and IB in combination produced protection against histamine and AMP that was more than the production produced by either drug alone, the GM PC20 values increasing to 54.76 and 47.7 mg/ml, respectively. There was no correlation between degree of bronchodilatation induced by active treatments and concentration ratios for AMP or histamine. These data suggest that histamine release and vagal reflexes both contribute to AMP-induced bronchoconstriction in clinical asthma in man.

Authors+Show Affiliations

Southampton General Hospital, England.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1673977

Citation

Polosa, R, et al. "The Effect of Inhaled Ipratropium Bromide Alone and in Combination With Oral Terfenadine On Bronchoconstriction Provoked By Adenosine 5'-monophosphate and Histamine in Asthma." The Journal of Allergy and Clinical Immunology, vol. 87, no. 5, 1991, pp. 939-47.
Polosa R, Phillips GD, Rajakulasingam K, et al. The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5'-monophosphate and histamine in asthma. J Allergy Clin Immunol. 1991;87(5):939-47.
Polosa, R., Phillips, G. D., Rajakulasingam, K., & Holgate, S. T. (1991). The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5'-monophosphate and histamine in asthma. The Journal of Allergy and Clinical Immunology, 87(5), 939-47.
Polosa R, et al. The Effect of Inhaled Ipratropium Bromide Alone and in Combination With Oral Terfenadine On Bronchoconstriction Provoked By Adenosine 5'-monophosphate and Histamine in Asthma. J Allergy Clin Immunol. 1991;87(5):939-47. PubMed PMID: 1673977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5'-monophosphate and histamine in asthma. AU - Polosa,R, AU - Phillips,G D, AU - Rajakulasingam,K, AU - Holgate,S T, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 939 EP - 47 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 87 IS - 5 N2 - The aim of this study was to investigate the effect of terfenadine, an antihistamine, 180 mg orally, the anticholinergic drug, ipratropium bromide (IB), 0.5 mg nebulized aerosol, the combination of these two drugs, and placebo tablets and aerosol on histamine- and adenosine 5'-monophosphate (AMP)-induced bronchoconstriction in a randomized, double-blind fashion. Airway response was evaluated as FEV1. After placebo, the geometric mean (GM) provocative concentration causing a 20% in FEV1 from the postsaline baseline value (PC20) for histamine and AMP was 0.63 and 5 mg/ml, respectively. Terfenadine displaced the FEV1 concentration-response curves obtained with both histamine (GM PC20 values increasing to 26.92 mg/ml) and AMP (GM PC20 values increasing to 26.7 mg/ml) to the right. IB had a small, but significant, protective effect against the fall in FEV1 produced by histamine and AMP, the GM PC20 values increasing to 1.69 and to 12.6 mg/ml, respectively. Terfenadine and IB in combination produced protection against histamine and AMP that was more than the production produced by either drug alone, the GM PC20 values increasing to 54.76 and 47.7 mg/ml, respectively. There was no correlation between degree of bronchodilatation induced by active treatments and concentration ratios for AMP or histamine. These data suggest that histamine release and vagal reflexes both contribute to AMP-induced bronchoconstriction in clinical asthma in man. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/1673977/The_effect_of_inhaled_ipratropium_bromide_alone_and_in_combination_with_oral_terfenadine_on_bronchoconstriction_provoked_by_adenosine_5'_monophosphate_and_histamine_in_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-6749(91)90415-K DB - PRIME DP - Unbound Medicine ER -