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Molecular biological approaches to the study of heritable osteoarthritis.
J Rheumatol Suppl. 1991 Feb; 27:7-9.JR

Abstract

Certain forms of osteoarthritis (OA) are inherited in a dominant Mendelian pattern suggesting that defects in one or more of the genes encoding for the structural components of articular cartilage may cause premature cartilage degeneration. Recent advances in molecular biology make it possible to examine the hypothesis that inherited OA is caused by mutations in the genes expressed in cartilage. These methods permit the identification of precise molecular defects and, eventually, may provide tests for the definitive diagnosis of inherited OA. Application of these tests to a general population of patients with OA may establish whether common forms of OA are also caused by mutations in these genes.

Authors+Show Affiliations

Jimenez SA
Rheumatology Research, Thomas Jefferson University, Philadelphia, PA 19107.

MeSH

AnimalsCartilage, ArticularCloning, MolecularCollagenDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicMutationOsteoarthritisPolymorphism, Restriction Fragment LengthRecombination, Genetic

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

1674006

Citation

Jimenez, S A.. "Molecular Biological Approaches to the Study of Heritable Osteoarthritis." The Journal of Rheumatology. Supplement, vol. 27, 1991, pp. 7-9.
Jimenez SA. Molecular biological approaches to the study of heritable osteoarthritis. J Rheumatol Suppl. 1991;27:7-9.
Jimenez, S. A. (1991). Molecular biological approaches to the study of heritable osteoarthritis. The Journal of Rheumatology. Supplement, 27, 7-9.
Jimenez SA. Molecular Biological Approaches to the Study of Heritable Osteoarthritis. J Rheumatol Suppl. 1991;27:7-9. PubMed PMID: 1674006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular biological approaches to the study of heritable osteoarthritis. A1 - Jimenez,S A, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 7 EP - 9 JF - The Journal of rheumatology. Supplement JO - J Rheumatol Suppl VL - 27 N2 - Certain forms of osteoarthritis (OA) are inherited in a dominant Mendelian pattern suggesting that defects in one or more of the genes encoding for the structural components of articular cartilage may cause premature cartilage degeneration. Recent advances in molecular biology make it possible to examine the hypothesis that inherited OA is caused by mutations in the genes expressed in cartilage. These methods permit the identification of precise molecular defects and, eventually, may provide tests for the definitive diagnosis of inherited OA. Application of these tests to a general population of patients with OA may establish whether common forms of OA are also caused by mutations in these genes. SN - 0380-0903 UR - https://www.unboundmedicine.com/medline/citation/1674006/Molecular_biological_approaches_to_the_study_of_heritable_osteoarthritis_ DB - PRIME DP - Unbound Medicine ER -